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WASHINGTON, April 6 (Xinhua) -- U.S. researchers have discovered two genes in which variation affects intake of caffeine, the most widely consumed stimulant in the world, according to a report described Wednesday in the open-access journal PLoS Genetics.A team of investigators from the National Cancer Institute, Harvard School of Public Health, Brigham and Women's Hospital, and the University of North Carolina at Chapel Hill examined genetic variation across the entire genome of more than 47,000 individuals from the U.S.They found the genes -- CYP1A2, which has previously been implicated in the metabolism of caffeine, and AHR, involved in the regulation of CYP1A2, played roles in regulating intake of caffeine. Individuals with the highest-consumption genotype for either gene consumed 40 mg more caffeine than those with the lowest-consumption genotype, equivalent to the amount of one-third cup of caffeinated coffee, or one can of cola.Caffeine is implicated in numerous physiological and medical conditions; it affects sleep patterns, energy levels, mood, and mental and physical performance. The identification of genes that have an impact on daily consumption offers opportunities to better understand these conditions. Further exploration of the identified genetic variants may provide insight into the speed of caffeine metabolism, how long caffeine circulates in the blood, or how strong the physiological effects of consuming a given amount of caffeine are.
TIANJIN, April 16 (Xinhua) -- As China tries to establish a universal medicare umbrella, its first move to offer treatment to all the hemophilia patients in the country is to know their population and where they are.China's national hemophilia information management center registered 7,980 cases nationwide since its establishment last year in a bid to provide reference for making national treatment policies and medicine production quota, said the center officials Saturday.Yang Renchi with the center and the Chinese Academy of Medical Sciences, said that the patient information database will help the government make hemophilia-related medical and social welfare policies, optimize resources and guide the manufacturing of drugs such as coagulation factor VIII.The information center, created by the Ministry of Health, is located in the Blood Diseases Hospital of the Chinese Academy of Medical Sciences in the port city Tianjin in north China.Hemophilia is a rare genetic bleeding disorder that prevents the blood from clotting properly, resulting in easy bruising and prolonged bleeding from trauma. Lack of treatment can lead to permanent disabilities or even death.China is estimated to have roughly 100,000 hemophilia patients."Be inspired; get involved in Treatment for All" is the theme for the 22nd World Hemophilia Day, which falls on Sunday, April 17."A necessary precondition for 'Treatment for All' is to know the clinical information and location of each case," said Yang, "and this is exactly what the information system does."In addition, China plans to establish hospital-based provincial hemophilia management centers within five years across the country to register and monitor patients and standardize disease diagnosis and treatment under the information system.SHORTAGE OF DRUGSBlood-derived coagulation factor VIII and recombinant coagulation factor VIII are two effective drugs which are vital for hemophiliacs. However, the drugs are expensive and produced in limited quantities, a difficulty which hundreds of thousands of hemophiliacs in China have to confront.According to Yang, the minimum dose of coagulation factor VIII for prevention of bleeding episodes is two international units (IU) per kg of weight a day. A 50-kg hemophilia patient needs at least 36,500 IU of factor VIII every year to prevent bleeding."Each IU of blood-derived coagulation factor VIII costs about 3 yuan(0.46 U.S. dollars) and the annual cost is almost 120,000 yuan. The recombinant one is almost twice the price," said Yang.Only four drug firms are qualified to manufacture blood-derived coagulation factor VIII in China. The national output in 2010 was 400,000 vials (200 IU per vial) which means 80 million IU for the entire country.Wu Runhui, a hematology specialist with the Beijing Children's Hospital, said that the minimum dose is only for the prevention of bleeding episodes which are required to keep the patient alive. For the hemophiliac to live a regular lifestyle, 3,000 IU per kilo a year is needed, which would cost half a million yuan a year."Even in the most developed countries, a hemophiliac cannot survive without supportive medical policies and social welfare system," said Wu.

BEIJING, Feb. 27 (Xinhua) -- A total of 2.64 billion trips in China were recorded by road or ships during the 40-day Spring Festival transportation season which ended Sunday, the Ministry of Transport said.The figure was 13.6 percent higher than the same period last year, noted ministry spokesman He Jianzhong.To ensure smooth transportation, 840,000 buses were put into use each day during the busy season, as well as 13,089 ships, He said.Statistics on railway transportation are not yet available.However, statistics from the Beijing railway administration showed 20.63 million tourists had left Beijing during the transportation season from Jan. 19 to Feb. 27, up 3.9 percent year on year.The busy Spring Festival transportation season runs for 40 days and is calculated in two phases: 15 days before and 25 days after the Spring Festival.
BEIJING, May 23 (Xinhuanet) -- A new study suggests that crossing your arms could reduce the intensity of pain, according to media reports.The study was conducted by researchers from University College London (UCL), who reported their finding in the journel Pain.They said that crossing the arms could confuse the brain and conflicting information between the brain's two maps - one for the person's body and the other for external space - leading to a lower sensation of pain.A laser was used to generate a four millisecond pin prick on the hands of eight volunteers, who experienced this twice with their arms at their sides and arms crossed.Then the participants were asked to rate the intensity of pain in two situations and an EEG (electroencephalography) was used to measure their electrical brain responses.The results showed that both the perception of pain and EEG activity was reduced when the arms were crossed."Perhaps when we get hurt, we should not only 'rub it better' but also cross our arms," said Giandomenico Iannetti of UCL's department of physiology, pharmacology and neuroscience.
BRASILIA, March 15 (Xinhua) -- A nationwide program aimed at providing internet access to 80 percent of the country's population by 2014 is forging ahead in Brazil, Communications Minister Paulo Bernardo said on Tuesday.The National Broadband Plan (PNBL), with participation of 13 ministries, is coordinated by Bernardo, who explained details about the project on Tuesday along with Joao Santana, president of Telebras, the state-owned enterprise responsible for managing the project.The authorities have criticized companies that offer internet service for failing to spread internet use in Brazil, offering an expensive service with prices amounting to about 50 U.S. dollars monthly, inaccessible to low-income families."We ended 2010 with 34 percent of Brazilian households with Internet access, and service is also very poor. Almost half of connections are of 256 mbps. We are out-of-date, with the aggravating circumstance that the connections are very expensive," Bernardo said.To speed up the process, the government started negotiating with concessionaire phone companies to improve the service quality and lower the price to about 30 reais (18 dollars), which would allow 80 percent of the population to access internet."During (former president) Lula da Silva's government, we developed a program to interconnect all schools with internet access, but we also want the private sector to do its share," he said.
来源:资阳报