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As the world waits for deliveries of Pfizer’s coronavirus vaccine, the pharmaceutical company is having to adjust their target after hitting supply chain obstacles, according to the Wall Street Journal.“Scaling up the raw material supply chain took longer than expected,” a company spokeswoman told the WSJ.Pfizer and partner BioNTech SE had hoped to ship out 100 million doses of their vaccine by the end of the year, that has now reportedly been cut to estimates of about 50 million.Two doses are needed for each person to be vaccinated.Pfizer did not elaborate on where the raw material shortfalls happened. They did say some raw materials in early production earlier this year did not meet their standards and they had to fix the issue.After the WSJ’s report, Pfizer’s stock price dropped and the S&P 500 fell slightly.The United Kingdom has granted emergency use of the Pfizer vaccine, and is expected to start administering doses soon. The FDA in the U.S. is considering a similar authorization, which could come later in December.As part of Operation Warp Speed, the U.S. Government has purchased 100 million doses of Pfizer’s vaccine, with an option to buy more.Roughly 20 million of those doses were expected by the end of the year once the FDA granted emergency use authorization. No word on how Pfizer’s shipping delays could impact this number.Pfizer says their production lines in the U.S. and Europe are complete and they are “confident” they will supply the targeted number of doses in early 2021. 1524

Atal Bihari Vajpayee, India's tenth prime minister, died Thursday in New Delhi at the age of 93.A statement released by the hospital treating him said "his condition deteriorated over the last 36 hours and he was put on life support systems. Despite the best of efforts, we have lost him today.""India grieves the demise of our beloved Atal Ji. His passing away marks the end of an era. He lived for the nation and served it assiduously for decades. My thoughts are with his family, BJP Karyakartas and millions of admirers in this hour of sadness. Om Shanti," tweeted Indian Prime Minister Narendra Modi.Celebrity deaths of 2018: Remembering those we've lost this yearVajpayee was prime minister briefly in 1996 and 1998 before eventually serving a full term as premier from 1999 to 2004. He had been admitted in June to the All India institute of Medical Sciences in the capital, suffering from a urinary tract infection and chest congestion. His condition worsened, eventually becoming fatal.Vajpayee never married. He is survived by his adopted daughter, Namita.During his political career, Vajpayee's name became synonymous in India with the rise of the ruling Bhartiya Janata Party (BJP), which he helped found in the 1980s. His ascent to the premiership signaled the renewal of the party, which had grown to become the main opposition to the Indian National Congress before eventually overtaking that party.Vajpayee's tenure as India's leader was marked by significant developments in the country's defense policy, and he oversaw India joining the world's nuclear weapons club in 1998.Facing heavy criticism at home and abroad over India's nuclear ambitions, Vajpayee defied the threat of economic sanctions, telling parliament that "we have never made a decision after coming under international pressure and we will never do so in the future."Born in December 1924, Vajpayee grew up in the central Indian state of Madhya Pradesh and was one of the founders of the Janata Party, a splinter group of which became the modern BJP. During his youth he was briefly a member of the right wing Hindu nationalist group Rashtriya Swayamsevak Sangh (RSS), and was arrested along with his brother in 1942 for protesting against British rule.Vajpayee won his first election to parliament in 1957, a decade after independence. He would go on to hold that role for nine terms.Though he was elected prime minister three times, Vajpayee only competed an entire term once. His first government collapsed in less than three weeks in 1996, and while he took power again in 1998, this only last 13 months before a disagreement within the ruling coalition sparked new elections.Vajpayee was returned to the premiership in 1999 after his BJP-led coalition secured a comfortable majority in the wake of a two-month long war with Pakistan over control of Kashmir.In late 2001, India's parliament was hit by a terrorist attack which Delhi blamed on Pakistan, while in 2002, riots in Gujarat claimed the lives of hundreds of Muslims.Despite India's contentious seven-decade relationship with Pakistan, Vajpayee is credited with being the only Indian leader to make significant progress in peace talks with the country's nuclear-armed neighbor.Even as he pursued a nuclear agreement with Pakistan, Vajpayee remained a defiant defender of India's security policy, an approach which eventually paid off. Economic sanctions imposed after the country's first atomic test were finally lifted in 2000 when Bill Clinton visited the country, the first US President to do so in 22 years. Vajpayee also improved relations with Beijing, officially recognizing Tibet as part of China.A talented orator, one of Vajpayee's most remembered speeches was a hugely critical one, bemoaning India's lack of progress after five decades of independence."Our country is counted amongst the poorest in the world," he said. "We can't make primary education a necessity. We are still expecting that girls should be educated. The birth of a girl in this country is still a curse."More than 15 years after the speech was given, however, the country continues to be plagued by many of the same problems.Away from politics, Vajpayee is also remembered as an accomplished poet, releasing many books over the years filled with Hindi poems.Just as his fellow BJP prime minister, Narendra Modi, has focused on promoting "brand India," Vajpayee saw great success in building his country's reputation around the world. He addressed the United Nations General Assembly in 2001 and a joint session of the US Congress in 2000. Bilateral agreements signed between his government and Moscow set the stage for annual summits which continue to this day, as does the close relationship with China he cultivated."At a time when an external stimulus has motivated us to unite against terrorism and for security, let us summon an equally strong inner resolve for development and poverty alleviation," Vajpayee said in his speech to the UN. "They are just as crucial for a global order at peace with itself."The-CNN-Wire 5061

At least 92 people in 29 states have been infected with a strain of multidrug-resistant salmonella after coming into contact with a variety of raw chicken products, the U.S. Centers for Disease Control and Prevention said Wednesday. Twenty-one of the sick patients have been hospitalized, though no deaths have been reported.The source of the raw chicken is unclear from lab tests, and no single common supplier has been identified. The strain has shown up in samples from a variety of raw chicken products including pet food, chicken pieces, ground pieces and whole chickens. The bacteria have also been found in live chickens. The U.S. Department of Agriculture's Food Safety and Inspection Service is monitoring the outbreak, and the CDC's investigation is ongoing.This particular salmonella strain is resistant to multiple antibiotics, the most common form of treatment.People sick with this strain have experienced stomach pain, cramps, diarrhea and fever 12 to 72 hours after exposure to the bacteria.Most people infected with salmonella, the most frequent cause of foodborne illness, get better in four to seven days without treatment. Symptoms can be worse for people with underlying medical conditions, children under 5 and people older than 65, as they typically have weaker immune systems.The CDC says the outbreak started in January, and more people have tested positive for this strain through September.The patients live in California, Washington, Texas, Nebraska, Missouri, Minnesota, Illinois, Indiana, Michigan, Ohio, Kentucky, Tennessee, Alabama, Louisiana, Georgia, Florida, South Carolina, North Carolina, Virginia, Maryland, Delaware, Pennsylvania, New Jersey, New York, Connecticut, Rhode Island, Hawaii, Massachusetts and Maine.Keep in mind that poultry can spread germs any time you handle it, the CDC notes, so always wash your hands when handling raw meat or poultry. Don't wash chicken before you cook it, as doing so can spread germs to other surfaces. Wipe down surfaces that have come into contact with raw meat, and use a separate cutting board. Cook chicken to a temperature of 165 degrees Fahrenheit to kill harmful bacteria.Some people may like to feed their cats and dogs raw chicken, but the CDC recommends against it. Germs in the food can make your pets sick, and you can get sick handling it.If you keep chickens as pets, getting too friendly with your fowl is also not recommended. Costumes may look cute on cats and dogs, but the CDC suggests that you avoid dressing your chickens up or cuddling with them to keep from being exposed to these bacteria. 2600

At least 35 people died after a section of a highway bridge in northern Italy partially collapsed Tuesday, the office of the Governor of the northwestern Liguria region said on its official Twitter account, citing unnamed sources from the fire department.A further 13 people were injured, five severely, according to Angelo Borrelli, head of the Italian Civil Protection Agency.Speaking to journalists Tuesday afternoon, Borrelli said that around 30 vehicles and several heavy-duty trucks were on the affected section of the Morandi Bridge, which lies to the west of the port city of Genoa, when it gave way.The number of casualties is expected to grow as the rubble is removed, Borrelli said, but it is unlikely that anyone was underneath the bridge at the time of the collapse, he added.Photos: The Morandi Bridge collapse in Genoa, ItalyAccording to police, violent storms were partly to blame for the disaster. Maintenance works were also underway at the time to consolidate parts of the bridge, according to motorway operator Autostrade. A bridge crane had been installed to allow those works to be carried out, the operator said in a statement."The works and the status of the viaduct were subject to constant observation and supervision," the statement said. "The causes for the collapse will be the object of an in-depth analysis a soon as it will be possible to safely access the site." 1403

As New Haven, Connecticut, Fire Chief John Alston Jr. spoke to reporters about a spate of drug overdoses on Wednesday, he heard shouting coming from behind him."We're getting another call of a person," Alston said.He quickly helped coordinate the response, and then returned to the microphone.That scene came on the same day that as many as 40 people in the area of New Haven Green were believed to have overdosed on some form of K2 that may have been laced with opioids, according to New Haven police spokesman Officer David Hartman.New Haven Green is a large park and recreation area in the city's downtown.The patients included people of various ages and demographics, Alston said."It's a nationwide problem. Let's address it that way," he said. "It's a nationwide problem that people are self-medicating for several different reasons, and every agency -- police, fire, medical hospitals -- all are strained at this time. This is a problem that's not going away."New Haven police said one person is in custody.Director of Emergency Operations for New Haven Rick Fontana said the patients had symptoms of increased heart rates, decreased respiratory rates and a lot of vomiting. Some people were unconscious, others were semi-conscious.No one has died, but two individuals are considered to be in serious, life-threatening condition. Some individuals who were released from the hospital needed to be treated a second time for an additional apparent overdose, Fontana said.K2 is a synthetic cannabinoid related to marijuana that is frequently laced with other drugs, said Dr. Sandy Bogucki of the Yale School of Public Health.In two cases, Narcan was not effective in the field, but a high dose of Narcan at the hospital was effective in combating the overdose effects. Because of that, authorities believe there was some form of opioid or synthetic fentanyl involved in the substance.The response from emergency responders has been "tremendous," Fontana said.He said authorities have been treating and sometimes transporting six or seven people at one time and the actions of first responders have been "lifesaving." 2131