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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

BEIJING, Jan. 21 (Xinhua) -- Chinese leaders on Saturday offered festive greetings to people across the nation as well as overseas Chinese around the world at a gathering to mark the Lunar New Year that falls on Jan. 23.President Hu Jintao, top legislator Wu Bangguo, Premier Wen Jiabao and top political advisor Jia Qinglin attended the gathering, organized by the Central Committee of the Communist Party of China (CPC) and the State Council at the Great Hall of the People in Beijing.Hosting the gathering, Hu, also General Secretary of the CPC Central Committee, extended regards to Chinese people at home and abroad and foreign friends on behalf of the CPC Central Committee and the State Council, the Cabinet.Premier Wen delivered a speech at the gathering, saying that the country has made a good start to the Twelfth Five-Year Plan (2011-2015) at a time of an austere and complicated international economic situation.Wen said the government would maintain stable prices and steady, rapid economic development, accelerate the transformation of development patterns and adjust the economic structure in a bid to enhance sustainable development, as well as place more importance on people's livelihoods, letting the people share the achievements of reform."We are going to face bigger challenges in the new year," Wen said. "We have the will, determination, courage and ability to overcome any difficulties. We have confidence in the motherland's successful and bright future."Wen said the country will resolutely take the socialist road with Chinese characteristics, and promote economic growth and social progress, as well as improving people's livelihoods, and democracy, rule of law, equality and justice."We need to keep a clear head and thoroughly apply the scientific outlook on development, so to advance the reform and openning up policy and the socialist modernization construction.Wen called for excellent achievements in a bid to put the country on a firm footing for the upcoming 18th National Congress of the Communist Party of China.Other leaders, including Li Changchun, Xi Jinping, Li Keqiang, He Guoqiang and Zhou Yongkang, also attended the gathering.The Spring Festival, or the Chinese Lunar New Year, is the most important traditional festival for China.

BALI, Indonesia, Nov. 19 (Xinhua) -- Leaders of China, Japan and South Korea met here Saturday to exchange views on trilateral cooperation and regional and international issues of common concern.Chinese Premier Wen Jiabao, Japanese Prime Minister Yoshihiko Noda and South Korean President Lee Myung-bak were meeting on the occasion of a series of meetings for East and Southeast Asian leaders in this Indonesian resort city on Friday and Saturday.Speaking at the meeting, Wen said the cooperation between the three nations currently had good momentum, which was not only in line with the interests of the three sides but also contributed to the stability and development of the Asia and the world.Chinese Premier Wen Jiabao (L), Japanese Prime Minister Yoshihiko Noda (C) and Republic of Korea (ROK) President Lee Myung-Bak pose for photos during the Trilateral Summit Meeting for leaders of the three nations in Bali, Indonesia, Nov. 19, 2011.As the coordinator of next year's China-Japan-South Korea cooperation, China would like to further enhance high-level exchanges, policy coordination and strategic trust between the three countries, providing political impetus and promoting more advancement in trilateral cooperation, Wen said.He said next year marked the 40th anniversary of the normalization of diplomatic relations between China and Japan, and the 20th anniversary of the establishment of diplomatic relations between China and South Korea.In the meeting, Wen proposed the joint research into a free trade area between the three countries be completed this year, and negotiations start in 2012.Wen also suggested enhancing trilateral cooperation in the fields of transportation, finance and environmental protection, among many others.Also speaking at the meeting, the Japanese prime minister and the South Korean president said the cooperation between the three nations had seen remarkable achievement and its prospects were promising.The three sides should continue to deepen their exchanges and cooperation in various fields including economy and trade, finance, investment, disaster relief, culture, education and tourism, and strengthen the coordination in regional and international issues to promote common development, according to them.During the meeting, the three leaders also exchanged views on other regional and international issues of common concern.

RIYADH, Jan. 15 (Xinhua) -- Visiting Chinese Premier Wen Jiabao and Saudi Arabia's King and Prime Minister Abdullah bin Abdul-Aziz agreed on Sunday to make concerted efforts to enhance bilateral relations under a strategic framework.In their meeting, Premier Wen said Saudi Arabia is a major country in the Arab and Islamic world, which plays a significant role in regional and international affairs.He said China respects Saudi Arabia's political system, development mode as well as its culture and traditions, and is grateful for Saudi Arabia's understanding of and support for China regarding the latter's core interests and major concerns.As the world is undergoing profound changes, China is willing to strengthen coordination with Saudi Arabia on major issues, develop an all-around cooperative partnership in the energy sector, expand cooperation in trade, investment, infrastructure, high-tech, finance, security and law enforcement, so as to enrich the contents of the bilateral relations, he added.King Abdullah said that the government and people of Saudi Arabia cherish friendly feelings for China, and that he believes the strengthening of bilateral cooperation will benefit peoples of both countries.The Saudi king proposed setting up a Saudi Arabia-China high level committee to supervise the two countries' cooperation in the political, economic, cultural and security sectors. Premier Wen agreed with this proposal.On the situation in West Asia and North Africa, the visiting Chinese premier said China respect the choice of the peoples in those countries, understand and support their appeal for reforms, and back the role of regional bodies like the Arab League in maintaining stability.For his part, King Abdullah noted it was the objective of Saudi Arabia's foreign policy to maintain regional peace and stability. Saudi Arabia and China enjoy a high level of mutual trust and share similar views on many issues, he said, adding that the Saudi side wishes to step up consultation and coordination with China.Premier Wen has also met with top Saudi leaders, Secretary General of the Organization of Islamic Cooperation Ekmeleddin Ihsanoglu, and Secretary General of the Gulf Cooperation Council Abdullatif al-Zayani.In a joint statement, the two sides hailed Premier Wen's visit to Saudi Arabia as a complete success, which will contribute to their long-term friendly cooperative relations.The statement said both countries were satisfied with the progress made in bilateral cooperation, and pledged to further enhance relations within the framework of strategic relationship, so as to benefit the two peoples and contribute to regional and world peace, stability and development.The two countries agreed in the document to conduct more high-level exchanges of visits, and to expand trade, investment and cooperation in a wide range of areas. The Saudi side also reiterated its adherence to the one-China policy.Wen arrived in Saudi Arabia Saturday evening after an official visit to Nepal.After his stay in Saudi Arabia, the Chinese leader will continue his visit to the United Arab Emirates and Qatar.

WASHINGTON, Oct. 18 (Xinhua) -- Scientists have increased the estimate of the number of humpback whales in the North Pacific Ocean, according to a paper published Tuesday in the Marine Mammal Science journal.The increase follows a refined statistical analysis of data compiled in 2008 from the largest whale survey ever carried out to appraise humpback whale populations throughout the North Pacific.The number of North Pacific humpback whales in the 2008 study, known as the Structure of Populations, Levels of Abundance and Status of Humpbacks, or SPLASH, was estimated at just under 20,000 based on a preliminary look at the data.The latest research indicates the population to be over 21,000 and possibly even higher -- a significant improvement to the scant 1,400 humpback whales estimated in the North Pacific Ocean at the end of commercial whaling in 1966."These improved numbers are encouraging, especially after we have reduced most of the biases inherent in any statistical model," said Jay Barlow, marine mammal biologist of the U.S. National Oceanic and Atmospheric Administration (NOAA)."We feel the numbers may even be larger since there have been across-the-board increases in known population areas and unknown areas have probably seen the same increases," Barlow added.The SPLASH research was a three-year project started in 2004 involving NOAA scientists and hundreds of other researchers from the United States, Japan, Russia and some other countries.It was the first systematic survey ever attempted to determine the humpback whales' overall population, structure and genetic makeup in the North Pacific.