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The Carr Fire raging in Northern California is so large and hot that it is creating its own localized weather system with variable strong winds, making it difficult for experts to predict which way the blaze will spread.At least 19 people were still reported missing in Shasta County, California, officials said at a community meeting Monday evening, after shifting winds, dry fuel and steep terrain helped the monstrous fire engulf more than 103,000 acres.The fire has claimed six lives, including a firefighter and bulldozer operator working to extinguish the blaze.Authorities have received 48 missing person reports but 29 people have since been found safe, according to Shasta County Sheriff Tom Bosenko.The fire, which started a week ago, has burned 103,772 acres and is just 23% contained, according to the California Department of Forestry and Fire Protection, known as Cal Fire. It has scorched an area bigger than the size of Denver. 951

The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499

The Department of Labor reported Thursday that 1.5 million Americans filed initial claims for unemployment during the week ending June 13, bringing a 13-week total to about 45 million claims.Thursday's figures were down about 58,000 from last week's unemployment filings.Weekly claims for unemployment have been falling for nearly three straight months after peaking at about 6 million a week in late March. But weekly unemployment claims remain historically high.Prior to the pandemic, the record high for weekly unemployment claims came in 2006, when 665,000 people filed for unemployment. The Department of Labor has been tracking the statistics since 1967.Economists often use weekly unemployment claims as a reliable tool when predicting unemployment. However, some surveys indicate that initial weekly claims may be underestimating the amount of those unemployed.At least one survey from the Economic Policy Institute found that millions of Americans gave up trying to seek benefits or didn't even attempt to due to states' overwhelmed and antiquated unemployment systems.Until recently, the stock market has been on a steady rise since March despite the staggering unemployment numbers. However, fears of the virus's resurgence caused the market to fall 600 points last week before recovering slightly this week. 1327

The CEOs for auto giants Kia and Hyundai have refused to attend a congressional hearing to explain why hundreds of their vehicles have spontaneously burst into flames.Both carmakers and a spokesman for Democrats on the Senate Committee on Commerce, Science and Transportation have confirmed the companies’ refusal to send representatives to the hearing, which has been scheduled for next week.A Kia spokesman said the company is working with the committee to “analyze all relevant information associated with any fire or other safety-related matters and will take any necessary corrective action in a timely manner.”A Hyundai spokesman said, “Hyundai takes this matter very seriously, and fully appreciates the concerns of the Senate Commerce, Science & Transportation Committee including those of the Chairman and Ranking Member.”It was not immediately clear whether the U.S. Senate committee would postpone or cancel its Nov. 14 hearing on Kia and Hyundai fires.The call for the hearing came six months after Consumer Investigator Jackie Callaway, of WFTS television station in Tampa, Florida, first reported on the unexplained car fires.Since April, the WFTS I-team has exposed hundreds of Kia and Hyundai models manufactured since 2011 that caught fire across the country.“The hearing will focus on motor vehicle safety issues involving vehicle fires,” stated the identical letters – dated Oct. 16 – and sent to Kia Motors America President and CEO Seungkyu “Sean” Yoon and Hyundai Motor America's Kyung Soo “Kenny” Lee.The CEOs were asked to “promptly identify and respond to defects that may pose a fire risk” at the Nov. 14 hearing in front of the Senate Committee on Commerce, Science and Transportation.In September, an Ohio mother spoke out and called for a federal investigation after watching her son burn alive in her 2014 Kia Soul parked at her apartment complex just outside of Cincinnati last year. 1926

The entertainment world is still reeling from the loss of Chadwick Boseman, who died on Friday at the age of 43. Boseman had reportedly been privately fighting colon cancer since 2016, meaning some of his most iconic roles — including those in films like Black Panther, Marshall and 21 Bridges — were likely filmed between grueling chemo treatments.In the face of such an insurmountable loss, doctors and medical professionals hope that Boseman's cancer battle can shine a light on the dangers of colon cancer in young and middle-aged people and encourage them to undergo annual screenings.According to the Centers for Disease Control and Prevention, colon cancer is currently the second-leading cause of cancer deaths in the United States. In 2017, more than 50,000 people died of the disease.And while colon cancer is most common in people 50 years and older, researchers say cases among younger people are on the rise.Researchers say that doctors have been able to catch the disease early in older people because of a push for increased screenings, but they're still at a loss for why the disease is increasing in young people — though rising rates of obesity may be a factor.Furthermore, Boseman's death is highlighting the rates of colon cancer in Black Americans — according to the American Cancer Society, Black people have the highest rates of colorectal cancer of any racial or ethnic group in the U.S.But what are the symptoms of the disease?According to the American Cancer Society, colon cancer typically presents with:Change of bowel habitsFeeling the need to go, but not feeling relief afterRectal bleeding with bright red bloodBlood in the stool making it look dark brown or blackCramping or abdominal painWeakness or fatigueUnintended weight lossWhile those symptoms don't necessarily guarantee a cancer diagnosis, the American Cancer Society recommends anyone with those symptoms visit a doctor.The Mayo Clinic adds that the following could leave a person with a higher risk of colon cancer:Old age (50 and above)Race factors (Black men are 24% more likely to develop colon cancer than white men, and Black men die 47% more likely to die of the disease than white men)History of colon tumors or polypsInflammatory intestinal conditions, like ulcerative colitis or Chron's diseaseFamily history of colon cancerA diet low in fiber and high in fatSedentary lifestyleDiabetesObesitySmoking/alcohol useHistory of radiation treatments in the abdomen 2468