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WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.

BEIJING, April 12 (Xinhuanet) -- The elderly have a difficult time with multi-tasking as a study suggests that older brains behave differently when it comes to switching between two tasks, according to media reports on Tuesday.Researchers used functional magnetic resonance imaging (FMRI) to analyze brain activity in 20 people over age 60 by asking them to contemplate outdoor photos shown briefly. Then the elderly were presented with the picture of a face and asked to determine its gender and age, before being asked to recall details from the original scene they viewed.Researchers then compared their results to a similar experiment with 20 younger adults and found the brains of older subjects were less capable of disengaging from the interruption and reestablishing the neural connections necessary to switch back to focusing on the original memory."Unlike younger individuals, older adults failed to both disengage from the interruption and re-establish functional connections associated with the disrupted memory network," write Wesley C. Clapp of the University of California, San Francisco, and colleagues in the Proceedings of the National Academy of Sciences.The study, published in the online edition of the journal Proceedings of the National Academy of Sciences, sheds new lights into a growing body of studies showing that one's ability to move from one task to another in quick succession becomes more difficult with age.
ADDIS ABABA, Jan. 28 (Xinhua) -- The on-going political crisis in Cote d’Ivoire should be and can be solved peacefully, Chinese Envoy and Assistant Foreign Minister Liu Zhenmin told Xinhua here on Friday, ahead of the 16th African Union (AU) summit scheduled for Jan. 30-31.Liu was in the Ethiopian capital Addis Ababa, the headquarters of the 53-member African bloc, to attend the summit as special envoy of the Chinese government.Cote d'Ivoire has been trapped in a political impasse since the landmark presidential run-off held on Nov. 28. Both incumbent Laurent Gbagbo and opposition leader Alassane Ouattara claimed victory and swore themselves in as president, and formed their respective government.Gbagbo was backed by the country's Constitutional Council, while Ouattara has the support of the electoral commission and the international community including the United Nations (UN), the AU, the Economic Community of West African States (ECOWAS), the United States and France.China hopes various parties and stakeholders in Cote d’Ivoire can resolve their disputes through dialogues and consultations based on the interest of the country and its people, and maintain peace and stability, Liu said.A peaceful solution to the crisis is not only in the interests of the Ivorian people, but of the West African region as a whole, according to Liu.China appreciates the efforts made by the AU and ECOWAS to find a peaceful solution to the crisis, and will continue supporting Africa’s efforts to resolve the crisis peacefully, Liu said.According to the UN, more than 200 people have died from violence during the power struggle between Gbagbo and Ouattara.The 16th AU summit, to be held under the theme “Towards Great Unity and Integration Through Shared Values,” will gather heads of states and government from member states to discuss issues including Africa’s integration, and peace and security in the continent. The situation in Cote d’Ivoire, among others, is expected to top the agenda of the summit.
BEIJING, Jan. 25 (Xinhua) -- A book collecting speeches made by Chinese President Hu Jintao during his state visit to the United States earlier this month has been published by the People's Publishing House.The book was distributed by Xinhua Bookstores Tuesday.
来源:资阳报