吉林医院龟头上有白色小颗粒(吉林尿道炎治疗) (今日更新中)

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

Three people have been killed in southern France after a gunman stole a car and took hostages in a town's supermarket, in what authorities are treating as a terror attack.Police shot dead the gunman, French media reported, after a four-hour standoff Friday at the Super U supermarket in the town of Trebes.Interior Minister Gerard Collomb identified the gunman as 26-year-old Redouane Lakdim. He was known to authorities for minor crimes, including drug offenses, Collomb said.The gunman had opened fire and killed two people there, he told reporters. One other was killed earlier in the carjacking in the city of Carcassonne."People were absolutely calm before and never though that there could be an attack in a town like this," Collomb told reporters, adding that the risk of terrorism in France was still "very high."A local prosecutor said the attack appeared to be "ISIS-inspired," CNN affiliate BFM TV reported. 926

Tough day for us at Twitter. We all feel terrible this happened.We’re diagnosing and will share everything we can when we have a more complete understanding of exactly what happened. ?? to our teammates working hard to make this right.— jack (@jack) July 16, 2020 271

Three people have been killed in southern France after a gunman stole a car and took hostages in a town's supermarket, in what authorities are treating as a terror attack.Police shot dead the gunman, French media reported, after a four-hour standoff Friday at the Super U supermarket in the town of Trebes.Interior Minister Gerard Collomb identified the gunman as 26-year-old Redouane Lakdim. He was known to authorities for minor crimes, including drug offenses, Collomb said.The gunman had opened fire and killed two people there, he told reporters. One other was killed earlier in the carjacking in the city of Carcassonne."People were absolutely calm before and never though that there could be an attack in a town like this," Collomb told reporters, adding that the risk of terrorism in France was still "very high."A local prosecutor said the attack appeared to be "ISIS-inspired," CNN affiliate BFM TV reported. 926

TORREY PINES (KGTV) - Two paragliders, one from San Diego and one from Orange County, died after colliding in mid-air and crashing into a cliff Saturday afternoon.It happened near Torrey Pines Gliderport around 2:45 p.m. Police confirmed both paragliders were men. One of the men was 61-years-old and the other man was 43-years-old, officials said. Both of the men were certified .Witnesses sat stunned when they watched the paragliders become intertwined, "I initially heard the collapse of the chute... I heard a collision, and some kind of sound, and looked over and saw two people falling from the sky," Madeline Henderson said."It was spinning but it was like in slow motion and I could see the guy, I don't know what he was trying to do but I felt bad for them," Irene Marquez said from the passenger seat of a car. She said it was her first time at the Gliderport and was traumatized by what she saw.Rescuers have recovered both of the bodies.Witnesses say the paragliders collided mid-air, a chute collapsed, and they spiraled to the ground and hit the cliffs. 1076

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