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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

San Diego (KGTV) — San Diego has several New Years Eve fireworks shows. While we may enjoy the sparkle and booms, your pets may run for their lives.“You don’t want to have them outside where all those loud fireworks are going off,” said San Diego Humane Society spokeswoman Dariel Walker. The organization sees a sudden spike in stray animals around this time of year, she said.Just like on July 4th, many pets who are terrified of loud noises run off in a panic. Walker suggested that owners prevent that by creating a calming environment for animals. “You can even even play music or have the TV on or have some noise in the background to drown out that loud sound of the fireworks,” Walker said. Walker advised pet owners to be prepared with a microchip in case they do run away. The San Diego Humane Society offers microchipping service for .The rice grain-size tracker goes into the back of the neck. It is administered similar to a regular vaccination shot and does not hurt the animal. Having a simple microchip is often the difference between reuniting or never seeing your runaway pet again, Walker said.“As soon as an animal comes into the shelter, the first thing we do is scan for that microchip, so as long as your information is up to date with the microchip, we can reunite them very quickly.”The San Diego Humane Society has special holiday hours on New Years Eve: 10am to noon.Microchipping services will be offered at that time. 1458

SAN DIEGO (KGTV) -- Residents in Pacific Beach are tired of the crime in their neighborhood. Some of them say - it's likely a lack of light that emboldens criminals. Wednesday, those neighbors brought the issue up with at a Pacific Beach Planning Group meeting, and offered a unique solution.  "Quality of life crimes are going up."Marcella Teran would know. She's lived here in the area for 30 years."We live by the Pacific Beach library, and there's so much crime over there and drug dealing," she said. "I just didn't feel safe at all."A few houses down, up in a tree above the sidewalk, Teran's neighbor took matters into his own hands."They're LED, solar powered, and it's super bright," she said, pointing out the lights her neighbor put up in front of his home. The best part is, they aren't expensive. Her neighbor purchased the lights online for less than , inspiring Teran to get a few of her own.  944

SAN DIEGO (KGTV) — San Diego is in bloom, making it the perfect time to get out and take in the area's natural beauty.The annual Cherry Blossom Festival returns to the Japanese Friendship Garden, bringing beautiful cherry blossoms to town with a multi-day festival. Julian will celebrate another flower as well, during their annual Daffodil Show.Head out to Santee Lakes and enjoy a night of games and entertainment, highlighted by a lake covered in lanterns during 1000 Lights Water Lantern Festival. And the beauty of voice hits Balboa Park, and a day full of choirs perform at the Spreckels Organ Pavilion during the San Diego Sings! Festival.RELATED: Things to do for free in San Diego CountyIt's a bit of a reverse for some, but beauty is in the eye of the beholder. Del Mar Fairgrounds will host an annual Ugly Dog contest, where you guessed it, we find the area's ugliest dog. The event will also hold contests for cutest dog and other categories as well.Here's a look at this weekend's happenings:THURSDAYDry Bar ComedyWhere: American Comedy Company; Cost: Bringing "comedy for everyone" to San Diego, Dry Bar Comedy heads to American Comedy Co. for a night of laughs free from vulgarities. The tour's online presence has generated more than 1 billion views and comics have been featured on late night stages including The Tonight Show, Jimmy Kimmel, Comedy Central, and more.26th annual San Diego Latino Film Festival Where: AMC Fashion Valley; Cost: - 0(Thursday - Sunday) The 26th annual San Diego Film Festival celebrates Latino culture, history, and arts over 11 days featuring more than 160 films from the U.S., Latin America, and Spain. The festival will host Q&A sessions with filmmakers and actors, a food,beer, and wine festival, and more experiences centered around Latino cinema.FRIDAY14th annual Cherry Blossom FestivalWhere: Japanese Friendship Garden of San Diego; Cost: (Runs Friday - Sunday) You don't have to head far from the county to enjoy springtime flowers. The Japanese Friendship Garden's Cherry Blossom Festival returns, opening up to the public for a festival featuring crafts, performances, a beer & sake garden, street food and blossoming cherry trees!7th annual Bankers Hill Arts & Crafts Beer FestivalWhere: The Abbey; Cost: - Enjoy tastes of delicious craft beer, bites from local eateries, and live music while artists showcase works covering paintings and fine art to photography and collaging to more, benefiting the Bankers Hill Business Group.SATURDAYWanderlust 108Where: Embarcadero Marina; Cost: - 0Celebrate an active lifestyle with a day filled with outdoor yoga, meditation, and lawn activities at Wanderlust 108. Lace up your shoes for a 5K run or walk and enjoy guided yoga from trainers at the Embarcadero!1000 Lights Water Lantern FestivalWhere: Santee Lakes; Cost: - Santee Lakes will be be covered in light as guests set decorated lanterns across the water during 1000 Lights Water Lantern Festival. Enjoy the sunset with games and entertainment, and food before the festival lights up the night.San Diego Sings! FestivalWhere: Balboa Park, Spreckels Organ Pavilion; Cost: FreeEnjoy a day filled with music from by a variety of choirs in Balboa Park. More than two dozen performances by choirs and organists will filled the day at Spreckels Organ Pavilion with music in this day-long free concert.Open House San Diego - San Diego's most iconic buildingsWhere: Various locations around the city of San Diego; Cost: FreeOn Saturday and Sunday, learn more about some of the more iconic buildings in areas such as downtown San Diego, Barrio Logan, Balboa Park and La Jolla. Join the tour to find out the history of these structures and other hidden gems. Tourgoers can also take part in a photo contest for prizes.SUNDAYAnnual Butterfly JungleWhere: San Diego Zoo Safari Park; Cost: - (Runs Saturday - Sunday) Walk through a greenhouse of butterflies of all colors and sizes at the San Diego Zoo Safari Park. Guests can feed butterflies and be guided through an array of the zoo's Butterfly Jungle inhabitants.15th annual Julian Daffodil ShowWhere: Julian Town Hall; Cost: Free(Runs Saturday - Sunday) Get ready for even more flowers this spring. Julian celebrates the spring season amid blooming excitement for local flowers with their Daffodil Show. Head up to the scenic mountain town for some seasonal beauty and stop in to smell the flowers at the show! 24th Annual Ugly Dog contestWhere: Del Mar Fairgrounds; Cost: - 0It's really a contest for a good cause. Del Mar's Ugly Dog contest will raise money for the Helen Woodward Animal Center's Animeals program for seniors. But the contest isn't just for the "ugliest" dog! Contests for cutest puppy, best trick, best costume, "looks most like its owner," and more will be held. 4846

SAN DIEGO (KGTV) - San Diego Police are investigating reports of a gunfight in the city's Chollas Creek neighborhood.Police officers responded to reports of two people, described as two black males, shooting at each other in the 5000 block of Auburn Drive shortly after 1:30 p.m. Thursday.The shooting occurred on a residential street just blocks from two elementary schools: John Marshall Elementary School and The Waldorf School of San Diego.No injuries have been reported. Police have not released any information on the suspects as of yet. 571