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As the world waits for deliveries of Pfizer’s coronavirus vaccine, the pharmaceutical company is having to adjust their target after hitting supply chain obstacles, according to the Wall Street Journal.“Scaling up the raw material supply chain took longer than expected,” a company spokeswoman told the WSJ.Pfizer and partner BioNTech SE had hoped to ship out 100 million doses of their vaccine by the end of the year, that has now reportedly been cut to estimates of about 50 million.Two doses are needed for each person to be vaccinated.Pfizer did not elaborate on where the raw material shortfalls happened. They did say some raw materials in early production earlier this year did not meet their standards and they had to fix the issue.After the WSJ’s report, Pfizer’s stock price dropped and the S&P 500 fell slightly.The United Kingdom has granted emergency use of the Pfizer vaccine, and is expected to start administering doses soon. The FDA in the U.S. is considering a similar authorization, which could come later in December.As part of Operation Warp Speed, the U.S. Government has purchased 100 million doses of Pfizer’s vaccine, with an option to buy more.Roughly 20 million of those doses were expected by the end of the year once the FDA granted emergency use authorization. No word on how Pfizer’s shipping delays could impact this number.Pfizer says their production lines in the U.S. and Europe are complete and they are “confident” they will supply the targeted number of doses in early 2021. 1524

Authorities believe they have found a package addressed to former Vice President Joe Biden that was considered suspicious due to its similarities to other packages sent this week to prominent Democrats and CNN, law enforcement officials said Thursday.The package was misaddressed and returned to sender, two law enforcement sources previously told CNN.Also on Thursday, a suspicious package addressed to actor-director Robert De Niro was reported at the Manhattan building where his production company is based, and its marking and contents appear similar to pipe bomb packages recently mailed nationwide to top Democrats, two law enforcement sources said.Law enforcement authorities are treating the series of bombs as a domestic terror matter and are advising the public to remain vigilant.Devices sent to former President Barack Obama, Hillary Clinton, former Attorney General Eric Holder, California Democratic Rep. Maxine Waters and Democratic donor George Soros showed the presence of a sulfur substance, which could have exploded, a law enforcement official said.The devices are believed to be pipe bombs, inherently unstable, and at risk of being set off just by handling.The FBI's counterterrorism division is leading the investigation Thursday into the packages and the agency says it's possible additional packages were mailed to other locations.The motive is unknown, but the recipients are all prominent targets of right-wing criticism and, in many cases, of President Donald Trump himself. The package found at CNN's New York bureau in the Time Warner Center was addressed to former CIA Director John Brennan, city and local law enforcement officials said.At the White House, Trump vowed Wednesday that "we will spare no resources or expense" to pursue the perpetrator.The-CNN-Wire 1803

ATLANTA, Ga. – Tuesday marks the first day of fall, which means people across the country are beginning to plan their Thanksgiving festivities.With the COVID-19 pandemic still ongoing, the Centers for Disease Control and Prevention (CDC) wants Americans to keep coronavirus risks in mind.Specifically, the CDC wants people to know that traveling for the holidays increases your chance of contracting or spreading the coronavirus.“Thanksgiving is a time when many families travel long distances to celebrate together,” the CDC wrote in an updated guidance. “Travel increases the chance of getting and spreading the virus that causes COVID-19.”The CDC says staying home is the best way to protect yourself and others, but if you must travel, health officials want you to be informed of the risks involved.The agency says these are considered lower-risk activities:Having a small dinner with only people who live in your householdPreparing traditional family recipes for family and neighbors, especially those at higher risk of severe illness from COVID-19, and delivering them in a way that doesn’t involve contact with othersHaving a virtual dinner and sharing recipes with friends and familyShopping online rather than in person on the day after Thanksgiving or the next MondayWatching sports events, parades, and movies from homeThese are considered moderate-risk activities:Having a small outdoor dinner with family and friends who live in your community (Lower your risk by following CDC’s recommendations on hosting gatherings or cook-outs)Visiting pumpkin patches or orchards where people use hand sanitizer before touching pumpkins or picking apples, wearing masks is encouraged or enforced, and people are able to maintain social distancingAttending a small outdoor sports events with safety precautions in placeThese activities are considered higher-risk and the CDC says they should be avoided to help prevent the spread of the virus:Going shopping in crowded stores just before, on, or after ThanksgivingParticipating or being a spectator at a crowded raceAttending crowded paradesUsing alcohol or drugs, which can cloud judgment and increase risky behaviorsAttending large indoor gatherings with people from outside of your householdClick here to learn more from the CDC about how to protect yourself and others from the coronavirus. 2352

As the coronavirus pandemic continues, doctors are learning more about the damage having Covid-19 can do to the body. Two separate studies published recently indicate the coronavirus can harm other organs in the body, including the heart.One of the studies looked at 100 patients in Germany who recently recovered from Covid-19 and found 60 percent of participants had inflammation in the heart. The study used MRI scans to monitor the inflammation, and was published in JAMA Cardiology.The majority of the patients in this study, 67 of them, recovered from the coronavirus at home with severity ranging from asymptomatic to moderate. It compared the MRIs of coronavirus survivors to scans from healthy volunteers.The data showed there was some sort of heart involvement in those who had coronavirus, whether or not they had preexisting conditions or any heart-related symptoms during recovery.“Our findings reveal that significant cardiac involvement occurs independently of the severity of original presentation and persists beyond the period of acute presentation, with no significant trend toward reduction of imaging or serological findings during the recovery period. Our findings may provide an indication of potentially considerable burden of inflammatory disease in large and growing parts of the population and urgently require confirmation in a larger cohort,” the researchers noted in conclusion.A second study, also published in JAMA Cardiology, found coronavirus could be found in the heart tissue of patients who died.The study looked at data from 39 autopsy cases in Germany in early April. The patients were aged 78 to 89, had tested positive for Covid-19 and there were results of heart tissue analysis in their autopsies.In 16 of the 39 cases, there was a large “virus load” of coronavirus found in the heart tissue, another eight had a coronavirus presence in the tissue.The sample of autopsy cases was small and the "elderly age of the patients might have influenced the results," the researchers wrote. More research is needed whether similar findings would emerge among a younger group of patients."Taken together the studies support that SARS-CoV-2 does not have to cause clinical myocarditis in order to find the virus in large numbers and the inflammatory response in myocardial tissue. In other words, one can have no or mild symptoms of heart involvement in order to actually cause damage," said Dr. Dave Montgomery, who was not involved in the studies, in a statement to CNN.Dr. Clyde Yancy of Northwestern University Feinberg School of Medicine and Dr. Gregg Fonarow of the University of California, Los Angeles, co-authored an editorial that accompanied the two new studies in the journal JAMA Cardiology called ‘Coronavirus Disease 2019 (COVID-19) and the Heart—Is Heart Failure the Next Chapter?”“We see the plot thickening and we are inclined to raise a new and very evident concern that cardiomyopathy and heart failure related to COVID-19 may potentially evolve as the natural history of this infection becomes clearer,” they write. 3076

AUSTIN, Texas -- Valarie Allman has been throwing discus for 10 years.“When you throw a discus it takes about two seconds, and it’s a combination of power, of grace, of strength… I like to think of it as a dance still," Allman said.She started sophomore year of high school. But it’s her dance background that she credits for her quick progression in the sport.“I had a weird knack for it," Allman said. "I think all those years of learning choreography and spinning and doing pirouettes weirdly carried over to the discus, and it kind of just seemed like a good fit right from the start.”Multiple days every week, she trains hard in the gym guided by her coach Zebulon Sion.“I’m responsible for every facet of her training," Sion said. "So that includes the strength-training concepts, if we do any type of running, fitness oriented things, plyometrics, and then of course the actual throwing.”Their chemistry is undeniable.At only 25 years old, Allman is considered a pro athlete. Her rigorous training is fueled by her desire to be a part of the next Olympics.“When I graduated college, I think that was the motivation to keep training. I missed the team in 2016 by three feet and it was kind of in that moment that I realized that I really wanted to try again,” Allman said.Consistency, discipline, attention to detail. Allman’s focus didn’t falter until she found out the 2020 Olympics had to be postponed.“It was pretty heartbreaking," Allman said. "I mean, to feel like you’ve put in so much to be prepared for it and to be healthy and to do everything right to feel like you’d have a chance to make the team and then for it to be postponed I think it kind of just made me question everything.”“Her motivation to throw kind of was gone a bit for her for a while," Sion said. "And then we kind of got to a point after a month, month-and-a-half of training going well in terms of lifting and training -- our goal was to get fit, get strong and refine the technical model that she has to get to a point where we could be at our best if that opportunity would come.”That opportunity did come. On August 1st in Rathdrum, Idaho, Allman beat the Women's Discus American Record.“I threw 70 meters and 15 centimeters, and the previous record was 69 meters and 17 centimeters.”The three-foot difference that kept her from qualifying for the Olympics in 2016 is the difference she surpassed to become the first and only American woman to throw past 70 meters.“When you’re throwing that type of distance, three feet is significant. So to break it by almost three feet was huge actually,” Sion said.“When they measured the throw and they read out the numbers and it started with a seven I instantly burst into tears. I was absolutely shocked,” Allman said.Allman says 70 meters is the ultimate barrier. In the past 20 years, only two other women in the world have thrown past 70 meters.“Now looking back it’s wild the think it was just a sliver of a difference of giving up when we were on the brink of something incredible,” Allman said.“We could have called it we could have said 2020 is a bust ya know let’s move on," Sion said. "But the amount of time, energy, effort all the things to put in over five months of uncertainty and then for that to happen – I don’t know if I could be more proud.”The same day of her record-breaking throw was the exact day she would have been competing in Tokyo had the Olympics continued. However, with her dedication to improvement, Sion believes there’s a great future ahead of Allman.“I mean I think the goal is just to throw farther and to keep throwing far more often. I mean it’s pretty simple,” Allman said.Even more simple when you’re having fun. 3692

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