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SINGAPORE, Oct. 10 (Xinhua) -- A Singapore start-up firm has devised an innovative application to allow phone users to have access to their positioning information within buildings, where traditional global positioning system has often proved inaccurate, local daily Business Times reported on Monday.The firm YFind Positioning System feels that the application can help turn Singapore into the world's first location- intelligent city.Ting See Ho, co-founder of the firm, said the application works by first verifying the GPS coordinates to identify the building the user is in, and then collecting RSSI (received signal strength information) readings off WiFi access points within the building.The information is then sent by the phone to the central positioning server for comparison against records of the radio map of the building, which is calibrated earlier by the company.Ting said the RSSI readings continually fluctuates, making it difficult to estimate a position. This is where YFind Positioning System steps in with its patent-pending probabilistic algorithms to help accurately estimated the user's indoor positions.Once the phone application determines the location, then, it is able to map a course for a shop or other destination within the building where the user wants to go."You can think of it as creating an 'indoor GPS' environment in the buildings where satellite signals cannot be read," Ting said.He said that more than ten organizations in Singapore have approached the company to discuss deployment and partnerships and that it has begun work on three proof-of-concepts.The company's immediate goal is to make Singapore the world's first location-intelligent city before going to other cities, he said.

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

SAN FRANCISCO, Nov. 11 (Xinhua) -- Google will launch its new music service next week, U.S. media reported on Friday.In an emailed invitation, Google said it will hold an event called "These Go to Eleven" next Wednesday in Los Angeles, which is expected to be the debut of Google Music, tech news website The Verge reported.Google is reported to be adding new features over the current version of its music service, such as a MP3 music store with connection to its social network Google+.According to a separate report from technology news site CNET on Friday, Google has not yet got licensing deals with all four of the major labels -- Universal Music Group, Warner Music Group, Sony Music Entertainment and EMI.Google introduced a beta version of its music service called Music Beta in May, enabling users to upload their entire music libraries for free to Google servers and stream songs from any browser or Android-based devices.Since the search giant failed to come to license agreements with major music labels at the time, Music Beta is essentially a massive cloud storage hard drive.

BEIJING, Jan. 8 (Xinhua) -- Only one in every three passengers secured train tickets on Saturday through a new online booking system or by phone, according to railway statistics released Sunday.A total of 2.112 million train tickets were sold online or by phone on Saturday, making up 36.3 percent of the total sales, the Ministry of Railways (MOR) said.Railway authorities have long been under pressure to increase capacity and improve ticketing services, as many find it extremely hard to secure a single ticket during major holidays such as the upcoming Spring Festival.The MOR set up an online ticketing system this year in a bid to ease passengers' frustrations in purchasing tickets.However, website glitches have added to the woes of travelers, especially migrant workers, who make up the biggest group in the Spring Festival travel rush.The rush, dubbed the world's largest seasonal migration, started Sunday and will continue for over 40 days.China's railways are expected to carry 235 million passengers over the next 40 days, up 6.1 percent year-on-year, the MOR said last week.The Spring Festival, or the Chinese Lunar New Year, falls on Jan. 23.

SINGAPORE, Oct. 10 (Xinhua) -- A Singapore start-up firm has devised an innovative application to allow phone users to have access to their positioning information within buildings, where traditional global positioning system has often proved inaccurate, local daily Business Times reported on Monday.The firm YFind Positioning System feels that the application can help turn Singapore into the world's first location- intelligent city.Ting See Ho, co-founder of the firm, said the application works by first verifying the GPS coordinates to identify the building the user is in, and then collecting RSSI (received signal strength information) readings off WiFi access points within the building.The information is then sent by the phone to the central positioning server for comparison against records of the radio map of the building, which is calibrated earlier by the company.Ting said the RSSI readings continually fluctuates, making it difficult to estimate a position. This is where YFind Positioning System steps in with its patent-pending probabilistic algorithms to help accurately estimated the user's indoor positions.Once the phone application determines the location, then, it is able to map a course for a shop or other destination within the building where the user wants to go."You can think of it as creating an 'indoor GPS' environment in the buildings where satellite signals cannot be read," Ting said.He said that more than ten organizations in Singapore have approached the company to discuss deployment and partnerships and that it has begun work on three proof-of-concepts.The company's immediate goal is to make Singapore the world's first location-intelligent city before going to other cities, he said.

来源：资阳报