太原大便干燥 出血(山西拉屎疼痛出血) (今日更新中)

WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

BEIJING, Oct. 18 (Xinhuanet) -- Autism can likely develop when low birth weight babies are combined with other factors such as environment and genetic predisposition, new research suggests.Researchers from the University of Pennsylvania School of Nursing and School of Medicine identified 1,105 children who weighed less than 2,000 grams at birth between Oct. 1, 1984, and July 3, 1989.Sixteen years later, researchers were able to reach 623 of those children, and used a questionnaire to screen them for autism spectrum disorders.When 189 of the children turned 21 years old, 60 percent of those who screened positive for an autism spectrum disorder, and 24 percent of those who screened negative with the condition. All in all, the rate of autism spectrum disorders among the study participants with low birth weights was five times higher than the general.Autism spectrum disorder makes people have difficulty communicating, difficulty interacting in social situations, and restrictive or repetitive interests, said study co-author Jennifer Pinto-Martin, a researcher in the University.Those with mild autism spectrum disorders, "may only want to talk about one subject," Pinto-Martin said. "They're perfectly functional. They can go to college. They can hold a job." Premature babies are often born with low birth weights, though full-term babies can also have the condition. The research suggests a need not only for better prenatal care to reduce the number of premature babies, but also a need for early diagnosis and intervention for people with autism.

WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

DOHA, Jan. 18 (Xinhua) -- Visiting Chinese Premier Wen Jiabao said here Wednesday that the Strait of Hormuz should be kept open under all circumstances and Beijing opposes "any extreme acts" at the strategic passageway."Any extreme acts across the Strait of Hormuz, under whatever circumstances they are taken, are against the common interests and aspiration of the people across the world," Wen told a press conference during his official visit to Qatar.The Chinese premier said that cargo transportation through the strait should be protected because it concerns the interests of the whole humanity.Chinese Premier Wen Jiabao attends a press conference in Doha, capital of Qatar, Jan. 18, 2012.China maintains that the Iranian nuclear issue should be resolved through peaceful means, he said, adding that Beijing supports the political process between Iran and the Iran Six, a diplomatic group made up of the United States, China, Russia, Britain, France and Germany.China firmly opposes Iran producing and possessing nuclear weapons and will work with concerned parties to establish a nuclear-free Middle East, Wen said, while stressing that China will not trade its principles for profits.However, just like many other countries, China has also kept "normal" and "justified" trade with Iran, which should be protected, Wen said, adding that should normal trade not be protected, the normal international order would be disturbed."I am not worried about the the normal trade between China and Iran at all," Wen told reporters.Wen arrived in Doha on Wednesday morning after concluding an official visit to the United Arab Emirates.

BEIJING, Jan. 22 (Xinhua) -- China restored 23,000 hectares of wetlands in 2011, according to the latest figures from the State Forestry Administration (SFA).An SFA spokesman said China reinforced wetland protection in 2011 by increasing subsidies in protecting wetlands. In the year the country carried out 42 wetland protection projects, increased 330,000 hectares of protected wetland areas, added four wetlands of international importance and 68 national wetland parks.The spokesman said in 2012 the country will further step up wetland protection and restoration, finish the second national wetland resources investigation and carry out pilot projects in assessing healthy conditions of the wetland ecological system.So far China has built more than 550 wetland natural reserves, 37 wetlands of international importance, which were listed in the Ramsar international wetland convention, and 100 national wetland parks. About half of the country's natural wetlands have been brought under effective protection, the SFA said.

来源：资阳报