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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.
LOS ANGELES, May 9 (Xinhua) -- Drinking alcohol may raise the likelihood among teenagers to spend more time on computers, a new study suggests.The study, conducted by researchers at Weill Cornell Medical College, was based on a survey of 264 teenagers, aged 13 to 17.Results showed that compared with teens who did not report drinking, those who drank alcohol in the last month used a computer more hours per week for non-school-related activities, including the use of social networking sites.Drinking was also linked to more frequent social networking and listening to and downloading music, according to the study published Monday in the on-line edition of the journal Addictive Behaviors.However, there was no demonstrated link between alcohol use and computer use for school work, neither there was strong link between video games and drinking or on-line shopping and drinking."While the specific factors linking teenage drinking and computer use are not yet established, it seems likely that adolescents are experimenting with drinking and activities on the Internet," said Dr. Epstein, assistant professor of public health at the college."In turn, exposure to on-line material such as alcohol advertising or alcohol-using peers on social networking sites could reinforce teens' drinking."Children are being exposed to computers and the Internet at younger ages. For this reason it's important that parents are actively involved in monitoring their children's computer usage, as well as alcohol use."Teenagers typically first experiment with alcohol at age 12 or 13, according to the study.Family risk factors include lax parental supervision and poor communication, family conflicts, inconsistent or harsh discipline and a family history of alcohol or drug abuse."According to a national study conducted by the Pew Internet and American Life Project, more than half of parents of teenagers had filters installed on the computers their child uses to block content parents find objectionable, yet many parents do not use any form of parental monitoring, particularly for older teens," Epstein said.

TAIPEI, Jan. 23 (Xinhua) -- Five crewmen, including four Chinese mainlanders, had been rescued after their fishing boat from Taiwan's Keelung capsized Friday night off southern Taiwan's Kenting, local sources said Sunday.The other two crewmen, including the Taiwanese captain and one mainland fisherman, were still missing. The rescue efforts were still under way.The fishing boat was ravaged by strong winds and huge waves Friday night.
BEIJING, Feb. 8 (Xinhua) -- As the Chinese Lunar New Year hoilday ended Tuesday, waves of Chinese residents began their journey back to work, as they boarded trains, airplanes and buses.The China Meteorological Administration announced Tuesday that a cold front would cause temperatures to fall by 4 to 12 degrees Celsius in most parts of the country, while some areas in the northwest, north and southwest will see rainfall or snow from Wednesday to Friday.Fleets of motorbikes carrying thousands of migrant workers passed through national roads again on Tuesday.The Ministry of Public Security said it set up 8,300 service stations along the country's major highways to provide free food, medicine, and rest stops for motor-riding migrant workers. The stations also sent police cars to clear the way for large groups of motorists.Chen Tianchong, a migrant worker from Muge County, Guigang City of southwest China' s Guangxi Zhuang Autonomous Region and 38 of his fellow migrant worker started their journey on motorcycles at 4:30 a.m. on the foggy National Road 324, which is a 2,712-kilometer road linking five provinces of Fujian, Guangdong, Guangxi, Guizhou and Yunan in southern China.A motorcycle usually carried two people, often a couple, sometimes with a child sandwiched in between. They would wrap themselves in thick outerwear to battle the cold weather at night. Limited access to cheap public transportation had forced many migrant workers to make their trips home on their own."I promised my boss that I would go back to the factory in Guangdong before Wednesday," said Chen.Chen said that they might arrive at Dali County, Shunde City of south China's Guangdong Province around eleven at night, after more than 18 hours riding a motorcycle from their hometown. By this way, each family may save more than 1,000 yuan - half of their monthly income.Zhong Fei, another migrant worker also from Guangxi, chose this way home during the Spring Festival for the past three years. Zhong told Xinhua that earning money for his family was the most important thing and the exhausting trip was nothing.From Guangdong alone, one of China's manufacturing bases, over 100,000 migrant workers left for home on motorbikes, said the local police. The Spring Festival travel rush started in China in the late 1980s, when millions of farmers from inland China moved to coastal cities to work.In spite the increasing popularity of motor cycles, the majority of Chinese travelers still prefer trains or buses. Shandong province embraced the post-holiday passenger rush Tuesday, with railway stations witnessing 200,000 passengers in a single day.Highway toll booths near Beijing, Shanghai, Tianjin and other big cities in China have become clogged.Passengers are also snapping up airplane tickets. China Southern Airlines had increased flights from 30 to 70 flights per day.Official forecasts indicate that this year's Spring Festival holiday may see a record 2.85 billion passenger trips nationwide, as Chinese workers return home from across the country for family reunions and go back to work after the holidays.
MADRID, Jan. 24 (Xinhua) -- The Spanish branch of Industrial and Commerce Bank of China (ICBC) was officially inaugurated in Madrid Monday.ICBC President Jiang Jianqing, Spanish Minister of Industry, Tourism and Commerce Miguel Sebastian and Chinese Ambassador to Spain Zhu Bangzao attended an inaugural gala dinner here.In a speech, Jiang thanked the Spanish government and authorities for allowing the ICBC to open in Spain and highlighted the importance of the Spanish economy and the close relations between the two countries.Sebastian said Spain welcomes the arrival of the biggest Chinese bank, which would further improve the already good relationship between the two counties.The Madrid branch is to provide a wide range of financial services to 166,000 Chinese nationals living in Spain.ICBC has a total of 386,723 employees and 162 foreign branches throughout the World.
来源:资阳报