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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The United States plans to end enhanced health screening of travelers from certain countries next week, and those visitors will no longer be funneled through 15 large U.S. airports.Those requirements were imposed in January to prevent the spread of COVID-19. The Centers for Disease Control and Prevention said the government will remove those edicts beginning Monday.The CDC said the current screening, which includes temperature checks and questioning travelers about COVID-19 symptoms, “has limited effectiveness” because some infected people have no symptoms or only minor ones. Travelers go through customs only after the health screening.The health agency said that of the 675,000 travelers who went through the process, fewer than 15 were found to have COVID-19 because of the extra screening.The health agency said that instead it will focus on other measures, including a stronger response to reports of illness at airports, collecting passenger-contact electronically to avoid long lines, and “potential testing to reduce the risk of travel-related transmission” of the virus.The extra health screening applies to people who have been in China, Iran, most countries in continental Europe, the United Kingdom, Ireland and Brazil. Most people coming from those countries who aren’t U.S. citizens have been barred entry to the country.The Homeland Security Department did not immediately respond to a request for comment Thursday.A trade group representing the nation’s largest carriers praised the change.“We continue to support spending scarce screening resources where they can best be utilized,” Airlines for America said in a statement Thursday, “and, given the extremely low number of passengers identified by the CDC as potentially having a health issue, agree that it no longer makes sense to continue screening at these airports.”Separately, 18 travel and airline groups asked the administration to start pre-flight virus testing as a way to reopen international travel. The groups argue that more screening could allow countries to lift travel restrictions and quarantines that have shut down most travel between the U.S. and Europe.Airlines including Delta and Southwest have lobbied the Transportation Security Administration to screen passengers for fever before allowing them on flights within the United States. However, the CDC questioned the usefulness of temperature screening because of the large number of infected people who do not have fevers, and no widespread screening of domestic passengers was launched.___This story has been updated to read that screening began at some airports in January, not February.___This story has been corrected to note that the COVID-19 health screening began at some airports in January, not February. 2771

The Trump campaign has dropped a central part of its lawsuit that seeks to delay the certification of election results in Pennsylvania, the state which proved to be the tipping point for Joe Biden in clinching the presidency.On Sunday, the Trump campaign dropped a portion of a lawsuit that alleged that more than 600,000 mail-in and absentee ballots were processed without Republican poll-watchers present. The claim has been a central part of President Donald Trump's argument that the 2020 election has been beset by widespread voter fraud.The Trump campaign's lawsuit now only focuses on claims that Republicans were "illegally disadvantaged" because some voters in Democratic-leaning counties were afforded the ability to fix mistakes on their mail-in ballots, a process called "curing." The Washington Post reports that the issue would likely only affect a small number of votes.Ballot curing is a process that takes place in several states. According to The Associated Press, there is no provision in Pennsylvania state law that prevents counties from affording voters the opportunity to cure ballots.Biden currently holds a lead of about 70,000 votes over Trump, with nearly all of the votes counted.Despite his campaign's altered lawsuit, Trump on Sunday continued to claim on Twitter — without providing evidence — that poll watchers "were thrown out of vote counting rooms in many of our States."Late Sunday evening, Trump tweeted, "I WON THE ELECTION!" a claim that quickly prompted Twitter to add a clarification to his message clarifying that "official sources have called this election differently." 1622

The strike that closed West Virginia's public schools for four days is over, West Virginia Gov. Jim Justice announced Tuesday evening.School will resume Thursday, he said.Teachers and school-related personnel will get a 5% raise in the first year and all other state employees will get a 3% raise, the governor said.The numbers still have to be passed by the Legislature.Justice said he had spoken to the leaders of the Senate and the House and he was "very, very hopeful" a bill would pass soon.The governor said he had changed his position on giving a raise this size after he had a conversation Monday with a sixth-grader named Gideon.Justice said Gideon was asking questions about tourism and the governor tried to explain about returns on investments in marketing.Turning one dollar into eight is a good investment, the governor told Gideon."Wouldn't it be an investment to invest in smart teachers that make me smart and then I can in turn, turn around and do smart, good things for our state?" the student replied.The governor said Gideon was right and he was approaching the strike wrong."I was looking at it as what the prudent thing was to do and not as investment." he said Tuesday.Dale Lee, president of the West Virginia Education Association, said the organization reserves the right to call teachers and service workers out again at a later date if the legislation gets bogged down or doesn't move ahead at their desired speed.Not all strikers pleasedThe strike put about 20,000 teachers and 13,000 school service employees on the picket lines to demand better pay and benefits.With the pay issue seemingly solved but insurance issues not, there was mixed reaction outside the state Capitol when the news was announced to the people on strike.There were big cheers for the pay raise, but boos for the lack of an immediate change to insurance.After they were told they would go back to schools Thursday with a possibility they might get called to strike again, teachers chanted "Back to the table!" and "Fix it now!"There are other issues, teacher saysWendy Peters, a third-grade teacher who traveled from Daniels, told CNN sister network HLN by phone that the primary issues are pay and insurance. But there are others, such as seniority and less stringent criteria that allow for noncertified teachers -- something Peters doesn't think should happen.She told "On the Story with Erica Hill" that teachers want to feel "valued and respected."Peters, who has 16 years of service and says she makes ,000, said teachers want a wage competitive with surrounding states. "We take care of the most important thing in our state, our children," she said.Legislation sparked strikeThe walkout -- which kept the state's roughly 277,000 public school students out of class -- came after Justice signed legislation late on the night of February 21, granting teachers a 2% pay increase starting in July, followed by 1% pay increases over the next two years.But the bill did not address further concerns of teachers, including issues with the teachers' public employees insurance program, the rising costs of health care and a tax on payroll deduction options, according to Christine Campbell, president of the American Federation of Teachers-West Virginia.Many people in West Virginia said that the high health insurance costs they face are the main sticking point in the work stoppage. That insurance affects all state employees.Tonya Spinella, a fourth-grade teacher in Mercer County, said rising insurance premiums are "going to be a real issue for us, for our family."She said she has a second job, teaching English to Chinese children online."And really, sometimes the only way we can make ends meet is through my second teaching job and through other little side jobs that I do," she?said. 3817

The U.S. will finish the month of November with more than 4 million confirmed cases of COVID-19, by far the most it has recorded in any month since the beginning of the pandemic.According to a database kept by Johns Hopkins University, the U.S. recorded 4.3 million new cases of COVID-19 throughout the month of November. That represents more than 30% of the 13.3 million cases recorded throughout the country since the virus reached the U.S. in February.Throughout November, the U.S. set 10 daily records for newly-reported COVID-19 cases. The peak came on Friday, when Johns Hopkins says the U.S. saw more than 205,000 new cases — though those numbers may have been skewed by the Thanksgiving holiday when some local governments chose not to report new info.The mountainous increase in cases has resulted in a frightening increase in hospitalizations and hospital resource use. According to the COVID Tracking Project, a record 93,000 Americans across the country were hospitalized with COVID-19 as of Monday morning, an all-time record. On Oct. 31, that figure stood at just over 47,000. While hospitalizations have spiked across the country, 66% of those hospitalized are in the Midwest and South, meaning many rural hospitals in those regions are at capacity. With hospitals full, doctors and nurses are struggling to treat patients who are suffering from other emergency ailments.Sadly, the number of deaths from COVID-19 has steadily increased throughout the month. As of Monday morning, an average of 1,436 Americans had died of COVID-19 each day for the last week. On Oct. 31, that figure sat at just over 800. Therapeutics and new treatments for the virus have caused the death rate to fall since the springtime when nearly 2,500 Americans were dying every day. But despite the improvements in treatments, the U.S. continues to lose about as many Americans every two days that were lost in the Sept. 11, 2001 terror attacks.And while several companies have reported encouraging news regarding potential vaccines in recent weeks, health experts warn the pandemic will get much worse before they are widely available.Prior to Thanksgiving, Dr. Anthony Fauci — America's top infectious disease expert — warned that the holiday could cause the rate of transmission to rise exponentially, given that some celebrations included large indoor gatherings."The chances are that you will see a surge superimposed on a surge," Fauci said. 2450

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