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WASHINGTON, Nov. 18 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Friday revoked its approval of Avastin for treating the breast cancer after concluding that the drug has not been shown to be safe and effective for that use.Avastin will still remain on the market as an approved treatment for certain types of colon, lung, kidney and brain cancer."After reviewing the available studies it is clear that women who take Avastin for metastatic breast cancer risk potentially life-threatening side effects without proof that the use of Avastin will provide a benefit, in terms of delay in tumor growth, that would justify those risks," FDA Commissioner Margaret Hamburg said in a statement. "Nor is there evidence that use of Avastin will either help them live longer or improve their quality of life. "Avastin's risks include severe high blood pressure; bleeding and hemorrhaging; heart attack or heart failure; and the development of perforations in different parts of the body such as the nose, stomach, and intestines.Avastin was approved for metastatic breast cancer in February 2008 under the FDA's accelerated approval program, which allows a drug to be approved based on data that are not sufficiently complete to permit full approval. After the approval, the drug's sponsor, Genentech, completed two additional clinical trials and submitted the data from those studies to the FDA. These data showed only a small effect on tumor growth without evidence that patients lived any longer or had a better quality of life compared to taking standard chemotherapy alone -- not enough to outweigh the risk of taking the drug.FDA's Center for Drug Evaluation and Research, which is responsible for the approval of this drug, ultimately concluded that the results of these additional studies did not justify continued approval and notified Genentech it was proposing to withdraw approval of the indication.Genentech did not agree with the Center's evaluation of the data and, following the procedures set out in FDA regulations, requested a hearing on the Center's withdrawal proposal, with a decision to be made by the Commissioner. That two-day hearing, which took place June 28-29, included recommendations from the FDA 's Oncologic Drugs Advisory Committee, voting 6-0 in favor of withdrawing approval of Avastin's breast cancer indication.
JIUQUAN, Oct. 26 (Xinhua) -- China will launch the spacecraft Shenzhou-8 in early November at the Jiuquan Satellite Launch Center in northwest deseart area.The unmanned spacecraft is expected to perform China's first space docking with Tiangong-1, or Heavenly Palace-1, a space lab module that was launched in September from the same launch center.The spacecraft and its carrier rocket, an upgraded Long March-2F, were transferred on Wednesday morning on a 20-meter-wide railway to the launch pad.The launch pad is 1,500 meters away from the assembling and testing center. It took nearly two hours to complete the transfer.Technicians completed testing on the assembling of Shenzhou-8 and the rocket after they were delivered to the launch center at the end of August, said Lu Jinrong, the launch center's chief engineer.In the next few days, the launch center will continue testing the spacecraft and the rocket, and inject propellent before the final launch in early November, Lu said.The assembling, testing and transferring of the spacecraft and rocket were all conducted while they were vertical.Shenzhou-8 is capable of docking with the spacecraft Tiangong-1 in both manual and automatic modes.The Tiangong-1 space lab module is functioning smoothly in the orbit, and all equipment and experiments are going well, according to Lu. The module is ready for the docking task, Lu said.

BEIJING, Nov. 30 (Xinhuanet) -- Heading football frequently may cause brain damage leading to subtle but serious declines in thinking and coordination skills, a new study suggested as quoted by media reports Wednesday.Researchers used an advanced MRI (Magnetic Resonance Imaging) technique to analyze changes in brain white matter of 32 adult amateur soccer players who head balls 436 times a year on average.The study found players who head football quite frequently -- with 1,000 or more a year -- showed abnormalities similar to traumatic brain injuries suffered in car accidents."This is the first study to look at the effects of heading on the brain using sophisticated diffusion tensor imaging," said Dr. Michael Lipton, a leading researcher and associate director of the Gruss Magnetic Resonance Research Center at the Albert Einstein College of Medicine in New York City."We found the real implication for players isn't from hitting headers once in a while, but repetitively, which can lead to degeneration of brain cells," he added.The researchers compared neurological images of study participants, whose average age was 31, and found those with the highest volume of headers had abnormalities in five areas of the brain, responsible for attention, memory, physical mobility and high-level visual functions.The findings come in the wake of mixed reports on the so-called "cognitive" consequences of frequently heading soccer balls at practice.Dr. Chris Koutures, a pediatrician and sports medicine specialist in Anaheim Hills, California, said the retrospective imaging study was fascinating, but needs more data to effectively determine safe header limits, especially for younger players.Dr. Lipton agreed neuropsychological damage from headers would be hard for a coach or physician to notice since cognitive problems develop gradually, and even players might not be aware of mild memory loss."We can't tell an individual today not to be heading a ball, but caution is a good thing," Lipton said. "We need more research for definitive answers and we have the advanced imaging tools to do it."
BEIJING, Dec. 9 (Xinhua) -- Beijing has seen a declining trend in newly built ordinary apartments in the past 11 months of this year, said a report released by the Beijing Real Estate Association on Friday.That average price of 13,914 yuan (about 2,194.23 U.S. dollars) per square meter from January to November went down 6.3 percent from the yearly average housing price of 14,847 yuan per square meter in 2010, also the target set by the municipal government in attempting to control soaring house prices, said the report.It is expected that the real-estate market in Beijing will maintain the gradually declining trend. And the target of "a stable yearly price with a slight decline" will be smoothly reached, said Chen Zhi, secretary-general of the association.In November, first-time home buyers took up about 90 percent of housing consumers for the ninth month in a row, which means the government's measures to crowd out investing or speculative buying and meet the demands of conventional buyers are working, the report said.This year the government has repeatedly stressed its efforts to contain the runaway property market, through measures including tighter monetary policies, higher down payments, a ban on third-home purchases, price control targets and a trial property tax.
RIO DE JANEIRO, Oct. 21 (Xinhua) -- Representatives from 120 countries attending the WHO's World Conference on Social Determinants of Health on Friday pledged to maintain investments in healthcare to reduce social gap.A statement adopted at the conference urged governments to maintain international collaboration and promote equal access to healthcare regardless of wealth.Brazilian Health Minister Alexandre Padilha said the economic woes in many countries cannot be a reason to "diminish" their social policies."The crisis cannot be an obstacle, instead it must be an opportunity to consolidate social policies," he said.Brazilian Foreign Minister Antonio Patriota said at the conference that health was an issue related to sustainable development, which will be discussed at the UN's Rio +20 Conference in 2012."The conference that ended today is an important step toward Rio +20," he said.
来源:资阳报