山西肛肠脓肿(山西痔疮专科谢肛泰) (今日更新中)

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) — Intense heat is sparking fires and sending San Diegans to the coast seeking relief."The temperatures today are pretty extreme," Cal Fire Captain Thomas Shoots said, adding the brush is dry from the heat and lack of rain making Wednesday's forecasted record heat very dangerous.A brush fire sparked in Ramona near Ramona St. and Boundary Ave around 11 a.m.The triple-digit heat causing concern for Fire Chief Jason Lambirth with the U.S. Forest Service, "we really take care of our own people, keep a close eye on them, make sure they're hydrated with water and Gatorade and go from there."Firefighters kept the blaze within a couple of acres, according to Shoots.A huge relief to neighbors, like Leanne Plunkett who has lived in Ramona for 44 years. "Oh I'm relaxed now, but it was pretty hectic for a while!" Plunkett said.She was stepping into the shower when law enforcement knocked on their door to issue evacuation orders. Plunkett said she jumped out, threw on clothes, and started packing jewelry and important documents.She said they had to evacuate twice in the past, including the Cedar Fire.The heat taking its toll on San Diegans across the county. Many, like Oscar Fuentes from El Cajon, headed to the beach."It was starting to get to 110 degrees out there so we decided to hit the beach... It's a lot more tolerable that's for sure it's really nice, I expect it's going to be a lot better when we get in that water."He's not alone according to Sgt. Lonnie Stephens with San Diego Fire Rescue's Lifeguard Division."We're still seeing elevated beach crowds on the weekends and during the weekdays." He said normally crowds dissipate after Labor Day but that hasn't happened yet."Throughout this heat, which has been ongoing for quite some time, yes we have had some citizens that have had some heat-related illness." He said it's important to wear loose-fitting clothing, drink plenty of water, wear sunscreen and stay in the shade when possible.An Excessive Heat Warning is in effect until Thursday night. 2045

SAN DIEGO (KGTV) — If there's one thing Californians know, it's that guacamole is always extra.Expect this weekend! National Chip and Dip Day comes on Saturday, but the fun starts Friday. Rubio's is giving away free chips and guacamole with any purchase on Friday and Saturday in celebration of the delicious event. Just present this coupon with any purchase and dip into some delicious freebies.At the very least, break open a bag at home and kick back with a handful of chips and side of dip. 502

SAN DIEGO (KGTV) - It's Signing Day for Lincoln High School seniors.In a first-ever ceremony for the school, college-bound seniors were honored for their hard work and accomplishments on campus Tuesday."It is to inspire underclassmen to aspire towards greatness like their senior counterparts," ASB advisor Malykke Bacon said in an email. "This ceremony is to celebrate these seniors and their accomplishments."RELATED: High Tech Middle student award Navy child of the yearPrincipal Jose Sotoramos took the stage and congratulated seniors before several waves of students stepped on stage and signed their letters of acceptance.Students like Jorge de la Cruz and Jhaunee Diggs plan to stay in-state. Cruz is heading to San Francisco State and become a politician one day. Diggs wants to return to San Diego after attending UC Davis to be a future pediatrician."We have many students doing the right thing every day. This ceremony gives them the opportunity to receive some shine," Bacon added. 1026

SAN DIEGO (KGTV) — Jurors have reached their verdict in the trial of a man accused of killing a Navy sailor on a Logan Heights freeway ramp in 2018.Edson Acuna, 26, was found guilty of first-degree murder, robbery, and several other charges in connection with the murder of 21-year-old Curtis Adams on Oct. 27, 2018. Adams was driving on I-15 at about 2 a.m., when he came upon what appeared to be a disabled vehicle. As Adams got out of his vehicle to check on the car's occupants when he was shot.Prosecutors say Acuna and three others had burglarized a Mt. Hope home that night, before getting into a shootout with the home's residents. As they fled, one of their vehicle's tires were shot out. RELATED COVERAGE:Closing arguments in trial for man accused of killing Navy sailor on freewayGunman kills good Samaritan in I-15 shooting near Mountain ViewSuspect in shooting of Navy sailor on freeway has criminal historyMurder suspect's brother arrested in Mexico, charged with Good Samaritan's deathAfter they pulled over, prosecutors say Acuna and the others believed the Navy man to be the homeowner and opened fire. Adam's girlfriend was also in the car with him at the time of the shooting.Acuna's 22-year-old brother, Brandon, and two other co-defendants, Harvey Liberato, 25, and Susana Galvan, 39, have pleaded guilty to charges including voluntary manslaughter and being an accessory after the fact.Adams enlisted in the Navy in 2016. At the time of his death, he worked as a steelworker with Amphibious Construction Battalion 1 at Naval Amphibious Base Coronado.Acuna was also found guilty of burglary, possession of firearm by a felon, transporting assault weapon, possession of assault weapon, prohibited person holding or possessing ammunition, and carrying loaded firearm in a vehicle. He was found not guilty of shooting at an inhabited structure, building or aircraft.He's set to be sentenced to life imprisonment without parole on April 10. 1965

来源：资阳报