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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617
SAN DIEGO (KGTV) — Memorial Day serves as a day to stop and remember those service members who have given the ultimate sacrifice.In San Diego, several memorial cemeteries will hold services to honor and commemorate these individuals.Elsewhere throughout the weekend, San Diegans will celebrate those freedoms ensured by military members with Memorial Day weekend events around town.Here's a look at Memorial Day services and events:ServicesFort Rosecrans Memorial DayWhen: May 27; When: Where: Fort Rosecrans National CemeteryA Memorial Day service will be held at Fort Rosecrans to honor fallen service men and women starting at 10 a.m. La Vista Memorial Park Memorial DayWhen: May 27; Where: La Vista Memorial ParkBeginning at 1 p.m., a Memorial Day service will be held at La Vista Memorial Park and Mortuary. Public officials on hand will be serving lunch.Mt. Soledad Memorial Day CeremonyWhen: May 27; Where: Mt. SoledadMemorial Day service will be held at Mt. Soledad at 2 p.m., with a special plaque presentation honoring Doris "Dorie" Miller, the first African-American Navy Cross recipient, awarded for his actions during Pearl Harbor.EventsPort of San Diego Festival of the SeaWhen: May 25 - 27; Where: San Diego Maritime MuseumFor the first time, the Port of San Diego is celebrating the sea and San Diego's 250th anniversary with a new community festival on the waterfront. Festival of the Sea features live performances, an artwork exhibition, and (for the older crew) a special on-board pub on the HMS Surprise.Legacy WeekWhen: May 24 - 27; Where: USS Midway MuseumLegacy Week marks San Diego's Memorial Day commemorations with a wreath laying ceremony, family activities, interactive exhibits, benefit concert with Daughtry, and more for the family, all from the USS Midway Museum. 1804
SAN DIEGO (KGTV) — If your New Year's resolution was to be more of a foodie, this month gives you the best chance to do so.San Diego Restaurant Week brings special pricing and delicious eats to hungry locals from Jan. 19 - 26. More than 180 restaurants take part in the week-long event, which offers two-course lunch price points from to , and three-course dinner options from to .Restaurant Week also gives diners the ability to play chef themselves and create their own meal using choices on prix fixe menus. Diners can assemble the perfect plates by choosing between drinks, appetizers, shared plates, or desserts. So, grab a couple of drinks and an appetizer for dinner, or two desserts for lunch.RELATED: Yelp's top place to eat at this year is a San Diego food truckTo take part in the delicious offerings, diners only need to visit a participating restaurant during the week and order from the special menu. Restaurants highly recommend making a reservation, but walk-ins are welcomed. Every restaurant also previews their Restaurant Week menu online, so diners can plan beforehand. A list of participating restaurants and their menus is available here. Participating restaurants include AVANT, Bali Hai, Cucina Urbana, JRDN, Puesto, and many more.Of course, restaurants will still offer their regular menu options as well. 1352
SAN DIEGO (KGTV) — Maverick has landed in San Diego!Eagle-eyed fans caught glimpses of actor Tom Cruise in Coronado Monday, on the set of the upcoming "Top Gun" sequel, "Top Gun: Maverick." The 56-year-old actor was spotted on a motorcycle (again) near the entrance of Naval Base Coronado by media and residents. But it's not a total surprise, as many were alerted to the possibility of filming last week, when the city posted "no parking" signs outside the base.RELATED: 500
SAN DIEGO (KGTV) - Kevin Luo of Pacific Trails Middle School has been crowned the winner of the 2018 countywide spelling bee. The event began at 9 a.m. at the McMillin Companies Event Center at Liberty Station and lasted for nearly four hours. Last year’s local winner was Pacific Trails Middle School student Yash Hande. Yash advanced to the 90th annual Scripps National Spelling Bee. Although he correctly spelled "Polynesian" in the second round and "demographic", he did not score high enough on his written test to advance to finals.WATCH THE BEE LIVE (MOBILE USERS CLICK HERE): 621