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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A person at Southwestern College has tested positive for tuberculosis and may have exposed others to the disease, the San Diego County Health and Human Services Agency announced Tuesday.The agency is working with the college to notify people who were possible exposed to TB. The period of possible exposure is from last Sept. 10 through Feb. 21, according to the HHSA.Tuberculosis is transmitted from person to person through indoor air during prolonged contact with an infectious person. Most people who are exposed do not become infected."We are recommending that all the identified people get tested to make sure they are not infected," said Dr. Wilma Wooten, the county's public health officer. "Early diagnosis and prompt treatment can prevent the infectious form of the disease."The HHSA and college are reaching out to students and other members of the public who possibly interacted with the positive-testing individual. They can go to the college's Student Health Services Student Center, Room 601F, 900 Otay Lakes Road, Wednesday and Friday from 8 a.m. to 3 p.m.Affected college employees will be tested separately by Occupational Health.The infected person was not publicly identified, nor did officials specify whether it was a student or staffer.Symptoms of active tuberculosis include persistent cough, fever, night sweats and unexplained weight loss. Tuberculosis can be treated and cured with medication. People who have TB symptoms or are immuno-compromised are encouraged to see their medical health care provider to rule out TB.Tuberculosis is not uncommon in the San Diego region but has been decreasing since the early 1990s and has stabilized in recent years. In 2013, 206 cases were reported in the county, the lowest number since local TB cases peaked at 469 in 1993. There were 237 cases reported in 2017 and 226 in 2018. Last year, 265 local residents were diagnosed with TB. 1927

SAN DIEGO (CNS) - Alliance of American Football team the San Diego Fleet will host a community drive Monday to collect donations of food, blood and necessities like clothes and soap.The event is the Fleet's first-ever donation drive since beginning play in the AAF in February. Donations made at the event will benefit the San Diego Blood Bank, the Alpha Project and the San Diego Food Bank. Residents who make a donation at the event will receive two free tickets to the team's last regular-season home game April 14.``Donations are critical to the San Diego Food Bank since we are currently feeding 350,000 people per month in communities throughout San Diego County,'' said James Floros, president and CEO of the San Diego Food Bank. ``On behalf of the food bank's staff and family of volunteers, we thank the San Diego Fleet for giving back to the community and helping our fellow San Diegans in need.''The Alpha Project is accepting donations of clothing, blankets, soap and shampoo. The food bank is seeking canned and non-perishable goods like soup, beans, peanut butter, rice and baby formula.The community drive is scheduled to begin at noon at SDCCU Stadium at 9449 Friars Road. 1196

SAN DIEGO (CNS) - Gov. Gavin Newsom announced Monday the state will send .7 million to support San Diego's proposed purchase of two hotels to provide more than 330 rental housing units for San Diegans experiencing homelessness.The funds -- part of the state's Project Homekey -- will go toward the purchase of the Residence Inn Hotel Circle and Residence Inn Kearny Mesa, to be considered by the San Diego City Council in October.The purchase of the two properties would create 332 permanent supportive housing units, with 72 of the units having two bedrooms, enough to provide housing for more than 400 individuals. According to a city statement, the units were determined to require minimal work before people could move in. The Hotel Circle property was built in 2003, while the Kearny Mesa property was built in 1990 and underwent a renovation in 2013."San Diego has proven we can put state dollars to action on programs and services that reduce homelessness," said Mayor Kevin Faulconer. "We have the real opportunity to house hundreds of individuals with these two hotels, and the Project Homekey grants will go a long way toward achieving that."RELATED: City of San Diego to buy hotels for permanent housing for the homelessThrough the Project Homekey program, the state is making 0 million in grant funding available to local public entities in California, including cities, counties or housing authorities. The grant funds may be used to purchase and rehabilitate housing, including hotels, motels, vacant apartment buildings, and other buildings, and convert them into interim or permanent, long-term housing.Residents of the two San Diego properties would include individuals currently staying at Operation Shelter to Home at the San Diego Convention Center -- which opened April 1 as a temporary shelter during the COVID-19 pandemic and serves about 1,100 people per day."The lack of housing options for our unsheltered residents is a humanitarian crisis, and confronting it is a top priority," said City Council President Georgette Gomez. "The clear solution is more homes, and so the announcement that the city of San Diego will receive substantial funding from Project Homekey to create new apartments with supportive services for some of our most vulnerable unhoused neighbors is very exciting news."The state awarded the funds based on applications the San Diego Housing Commission submitted."Securing two hotels, and bringing online over 330 permanent supportive housing units, is another example of our region implementing recognized best practices to protect the most vulnerable among us during COVID- 19," said City Councilman Chris Ward, who also serves as Chair of the Regional Task Force on the Homeless.The housing commission board voted 6-0 on Friday to recommend that the city council, in its role as the Housing Authority of the City of San Diego, authorize the purchase of Residence Inn Hotel Circle and Residence Inn Kearny Mesa.The County of San Diego Board of Supervisors voted unanimously Aug. 25 to approve Supervisor Nathan Fletcher's request to authorize .4 million to fund essential supportive services for the individuals who would reside at the properties.One of the main objectives of Operation Shelter to Home is to streamline how people experiencing homelessness access housing resources and move them quickly into permanent housing. So far, the project has helped more than 600 people secure housing.According to San Diego's Community Action Plan on Homelessness -- which the City Council adopted in October 2019 -- the city has a critical need to increase permanent supportive housing by 2,659 units for individuals experiencing homelessness within a decade, with 60% of those units, or 1,595, to be developed within the first four years. 3798

SAN DIEGO (CNS) - Federal officials in San Diego Wednesday announced the arrests of hundreds of suspects and the seizure of more than a ton and a half of narcotics as part of a crackdown on a Mexican criminal gang considered responsible for much of the flow of illicit drugs into the United States.During a late-morning briefing at the U.S. Drug Enforcement Administration's Kearny Mesa offices, DEA and Justice Department officials detailed the results of the multi-agency operation targeting the Cartel de Jalisco Nueva Generacion."Project Python is the single-largest strike by U.S. authorities against CJNG, and this is just the beginning," DEA Acting Administrator Uttam Dhillon said.The six-month enforcement campaign has resulted in the capture of more than 600 gang associates and 350 indictments, including one against the alleged head of the criminal organization, fugitive Nemesio Ruben Oseguera Cervantes, also known as "El Mencho."The Department of State has issued one of the largest narcotics crimes- related rewards ever -- million -- for information leading to the arrest of Cervantes.In San Diego and Imperial counties, the operation has led to the arrests of about 130 CJNG associates and seizure of 3,282 pounds of methamphetamine, 198 kilograms of cocaine, 59 kilograms of heroin, 44 kilograms of fentanyl, two kilograms of opium, in excess of 27,000 fentanyl pills and 18 guns, according to the DEA.The Jalisco-based cartel is one of the fastest-growing transnational criminal organizations in Mexico and among the most prolific methamphetamine producers in the world, and is the source of a large amount of drugs entering the United States and elevated levels of violence in Mexico, according to federal officials.Last month, Cervantes' son and second-in-command, Ruben Oseguera "Menchito" Gonzalez, was extradited from Mexico to the United States on drug- trafficking charges. Also in February, the alleged drug lord's daughter, Jessica Johanna Oseguera Gonzalez, was arrested in the United States on financial charges related to her suspected violations of the Foreign Narcotics Kingpin Designation Act."Today, DEA has disrupted CJNG's operations, and there is more to come as DEA continues its relentless attack on this remorseless criminal organization," Dhillon said. 2307

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