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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

DAVOS, Switzerland, Jan. 27 (Xinhua) -- A policy of more trade and greater openness to the rest of the world has brought significant benefits to China and greater market opportunities to its trading partners, the head of the World Trade Organization says."I don't think there is any question that China joining the WTO has been a very good thing for China and for the WTO and its members," WTO Director General Pascal Lamy said in an interview with Xinhua.The WTO chief was expected to join the forum "China's Impact on Global Trade and Growth" on the sidelines of the World Economic Forum annual meeting held in this Swiss alpine town."In joining the WTO, China successfully underpinned a policy of what had been 20 years of progressive openness," Lamy said.Adherence to economic reforms through international commitments ensured that China would stay on the path of openness, he noted, adding that the policy has helped the country economically, politically and socially.Lamy stressed that China has done a "remarkable job" in reducing poverty, which is an important task for the country, along with registering double-digit growth, thus becoming the world's largest manufacturer and the second largest economy.Apart from enhanced market access with its trading partners and more equal treatment in global trade, WTO membership also has allowed China to gain access to the organization's dispute settlement system, Lamy said.According to a WTO report issued in December, as the world's biggest exporter, China ranks first in receiving anti-dumping (AD) investigations, with 23 new AD initiations directed at its exports in the first half of 2010.In recent rulings arbitrated by the WTO Dispute Settlement Body (DSB), China has won a poultry dispute against the United States, and a steel fastener case against the European Union.Being a WTO member, "China would have a seat at the table as negotiations commenced on the trade rules for the 21st century," Lamy said, referring to the decade-long Doha round of global trade negotiations aimed at building the next generation trading system.Even more importantly, for China, participation in the global system of rules and discipline greatly boosted investors' confidence and helped facilitate foreign direct investment in China, he said.On the other side of the coin, China's integration into the world trading system has given enormous driving force to the global economy and market opportunity to its trade partners.

LOS ANGELES, May 2 (Xinhua) -- An asteroid will fly past Earth this fall at a close approach that will allow a close-up view of one of Earth's good-sized space rocks, NASA's Jet Propulsion Laboratory (JPL) announced on Monday."On November 8, asteroid 2005 YU55 will fly past Earth and at its closest approach point will be about 325,000 kilometers away," said Don Yeomans, manager of NASA's Near-Earth Object Program Office at the JPL in Pasadena, Los Angeles."This asteroid is about 400 meters wide -- the largest space rock we have identified that will come this close until 2028."Despite the relative proximity and size, "YU55 poses no threat of an Earth collision over, at the very least, the next 100 years, " Yeomans said in a press release."During its closest approach, its gravitational effect on the Earth will be so miniscule as to be immeasurable. It will not affect the tides or anything else.""While near-Earth objects of this size have flown within a lunar distance in the past, we did not have the foreknowledge and technology to take advantage of the opportunity," said Barbara Wilson, a scientist at JPL. "When it flies past, it should be a great opportunity for science instruments on the ground to get a good look.""The best resolution of the radar images was 7.5 meters per pixel," said JPL radar astronomer Lance Benner. "When 2005 YU55 returns this fall, we intend to image it at 4-meter resolution with our recently upgraded equipment at the Deep Space Network at Goldstone, California. Plus, the asteroid will be seven times closer. We're expecting some very detailed radar images."Asteroid 2005 YU55 was discovered in December 2005 by Robert McMillan, head of the NASA-funded Spacewatch Program at the University of Arizona, Tucson. The space rock has been in astronomers' crosshairs before.In April 2010, Mike Nolan and colleagues at the Arecibo Observatory in Puerto Rico generated some ghostly images of 2005 YU55 when the asteroid was about 2.3 million kilometers from Earth.

BEIJING, Feb. 14 (Xinhua) -- Chinese President Hu Jintao met with delegates from the national Party building society here Monday.Vice president Xi Jinping and He Guoqiang, secretary of the Central Commission for Discipline Inspection (CCDI) of the Communist Party of China (CPC), were also present at the occasion in the Great Hall of the People.The delegates were here to attend the fifth national congress of the national Party building society which was established in 1992.Addressing the meeting Monday, Li Yuanchao, head of the Organization Department of the CPC Central Committee, called on all the party building research staff to keep focusing on their study and be innovative in thinking about party building theory so as to strengthen party building in a more scientific way.The society revised its constitution and re-elected members of its council at Monday's meeting.

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