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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789
SAN DIEGO (CNS) - A San Diego man who sexually assaulted three women, some of whom were unconscious during the acts, was sentenced Friday to six years in state prison and ordered to register as a sex offender for life.Juan Carlos Cordero, 37, pleaded guilty in September to three felony sexual assault counts stemming from allegations that he assaulted women he met on dating sites or in person between 2015 and 2019.Cordero pleaded guilty to penetration of an unconscious victim by a foreign object, forcible sodomy and sodomy of an unconscious victim, with each count corresponding to women identified only as Jane Does 1 through 3.RELATED: San Diego women face their accused rapist at preliminary hearingSome of the victims alleged they may have been drugged by the defendant and testified during a preliminary hearing last year that while with Cordero, they blacked out and woke up in his bed, with little to no recollection of the previous night.Many testified that they discovered they'd suffered injuries that led them to believe they had been sexually assaulted.Some women testified they felt drugged the following morning but had no memory of how that may have occurred, while others testified that Cordero forced alcohol or drugs on them.RELATED: Sex assault suspect may have more victims, San Diego Police sayIn addition to the three victims Cordero pleaded guilty to assaulting, testimony also came from several other women alleging he committed similar acts on them, as state law allows testimony from alleged victims of defendants charged with sexual offenses in order to establish a pattern of behavior.Cordero was arrested in March 2019.Following his arrest and the District Attorney's Office filing of felony charges, San Diego police put a call out for any potential victims, stating that Cordero had been known to identify himself as "J.C." to young women in the area. 1895

SAN DIEGO (CNS) - Authorities reached out to the public Friday for help in identifying whoever has been hurling or shooting things at moving cars in Mission Bay Park in recent months, causing extensive property damage along with some injuries.On at least eight nights since November, someone has thrown or shot unidentified objects or projectiles at vehicles traveling in the area of Ingraham Street and West Mission Bay Drive, just west of SeaWorld San Diego, according to police.The targeted cars sustained damages, including dented bodies and broken windshields, totaling between 0 and ,000 each, officials said. Two drivers suffered minor cuts from flying glass.Since the crimes have taken place in the late evening or early morning on dark stretches of roadway, none of the victims has been able to provide a description of the responsible vandal or vandals.Anyone with information about any of the incidents is asked to call San Diego County Crime Stoppers at (888) 580-8477 or contact the agency online at sdcrimestoppers.org. Tipsters may remain anonymous and could be eligible for a reward of up to ,000. 1128
SAN DIEGO (CNS) -- After two weeks under quarantine, 63 people initially evacuated from China amid the coronavirus outbreak were released from Marine Corps Air Station Miramar Thursday."When we in China we were afraid of the coronavirus," said Ti Fan who was released from quarantine with his wife and daughter. "When we came to America we feel safety and happy."Fan said he did not mind being quarantined and it gave him an opportunity to spend uninterrupted quality time with his family."You helped us overcome the fear of coronavirus. God Bless America," he said.Other people released told 10News they enjoyed their stay and appreciated the Centers for Disease Control and Prevention (CDC) staff's patience and kindness. 731
SAN DIEGO (CNS) - A woman was injured by a hit-and-run driver early Sunday while walking on the curb line of a street in the Midway District.The victim was walking at 2:56 a.m. in the 3800 block of Camino Del Rio West when an unknown vehicle struck her and fled the scene, according to Officer S. Foster of the San Diego Police Department.She was taken to a hospital for treatment of her injuries, Foster said.The Traffic Division of the police department is investigating the hit and run. 497
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