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JAKARTA, Oct. 6 (Xinhua) -- United Nations Children's Fund (UNICEF) representative for Indonesia Angela Kearney said on Thursday that Indonesia's infant mortality rate is still high although it showed a downward trend in the past few years, local media reported.Based on a UNICEF global child mortality report, over the past 10 years infant mortality rate declined significantly to 35 out of every 1,000 births in 2011 from 97 out of every 1,000 births in 1991, she said at workshop on household to hospital cantinuum care held in Makassar, South Sulawesi.The achievement was inseparable from the central and regional government's endeavors, she said.After all, the results of a health demography survey showed 193, 000 children lost life chance every year before they reached the age of 5 years, she said.In South Sulawesi alone, 17.3 out of every 1,000 newborns died before they reached the age of 28 days last year. Two-thirds of the deaths occurred on the first week of their life and one out of every four mothers gave birth to their children without the help of trained medical workers.Mothers' poor access to health facilities in the country posed one of the obstacles to the promotion of the nation's health. One out of every five mothers came from poor families, she said.She said that a lack of infrastructures and equipment and the low number of trained medical workers had hindered the fulfillment of health services, the Antara news service said.To deal with the challenge, the method of providing health services must be improved and the support of trained medical workers must be increased, she said."I am very happy to see UNICEF cooperating with the South Sulawesi provincial government to develop comprehensive approaches to overcome the shortcomings at social level and public health system at provincial health facilities," she said.

NEW YORK, Oct. 14 (Xinhua) -- The iPhone 4S went on sale at Apple store on the Fifth Avenue of Manhattan in New York early Friday.An Apple store worker said people were waiting outside the store around 3 p.m. Thursday and underwent an overnight rain for an early purchase of the smart phone which started sale at 8 a.m. Friday.About 200 people were seen lining up outside the store and some of them said they would like to pay tribute to Steve Jobs, Apple's longtime CEO who died of pancreatic cancer at the age of 56 on Oct. 5."I'm a Steve's fan, iPhone 4S is the best of Steve's work. I am not going to buy iPhone 5,"Jim Bedford, who is in his 30s, said. "Maybe this is my last iPhone," he added.People left a Steve's picture, flowers and apples on the sidewalk to pay respect to Apple's co-founder. Some apples were seen inscribed such words as "Nice job" and "We will always remember you."Tom White, 50, said he had iPhone 1 and 3 and "now is the time to change a new one."The iPhone 4S is operated seven times faster than their predecessor and features an upgraded camera. Apple reported more than 1 million pre-orders for the iPhone 4S, breaking a mark set by last year's model. The phone also went on sale Friday in six other countries -- Britain,Germany,France,Australia, Canada and Japan.

YANGON, Nov. 10 (Xinhua) -- Myanmar surgeons have successfully separated the fifth conjoined twin baby girls, official media reported Thursday.The surgical operation by Dr. Htoo Han and his assistants was performed on the two-year-and-one-month-old conjoined twins named Ma Ingyin Khaing and Ma Ingyin Hlaing in the Children's Hospital in Yangon Wednesday, according to the New Light of Myanmar daily.The separated twins, who are under extensive care in the hospital, are from Kawtin village in Laungton township in southern Tanintharyi region.Myanmar surgeons had carried out four successful similar surgical operations on twins in the past over two decades.The fourth twins, who are also baby girls named So Pyay Lin and So Pyay Win with their chests joined together, were successfully separated in October 2009.

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.