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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A judge ruled Wednesday that President Donald Trump’s son Eric Trump must testify in a New York investigation into the family’s businesses before the November election. State Judge Arthur Engoron said Trump must comply with a subpoena for his testimony no later than Oct. 7. Eric Trump's lawyers had claimed his “extreme travel schedule” on the campaign trail warranted a delay. The judge said the investigation and the court are not “bound by the timelines of the national election.” Democratic State Attorney General Letitia James is investigating whether the Trump Organization lied about the value of its assets in order to get loans or tax benefits.“We will immediately move to ensure that Donald Trump and the Trump Organization comply with the court’s order and submit financial records related to our investigation," James said. "Further, Eric Trump will no longer be able to delay his interview and will be sitting down with investigators in my office no later than October 7. To be clear, no entity or individual is allowed to dictate how or when our investigation will proceed or set the parameters of a lawful investigation. The court’s order today makes clear that no one is above the law, not even an organization or an individual with the name Trump.” 1274

A historic bill to legalize marijuana at the federal level is expected to come up for a vote in the House of Representatives in December.This would be the first time a chamber of Congress has ever voted on removing marijuana from the Controlled Substances Act.Cannabis was included as what is called a Schedule I drug under the Controlled Substances Act in 1970. Schedule I drugs are defined as having a high potential for abuse and no medical benefit. Other Schedule I drugs include heroin, LSD, ecstasy and peyote.“I write to share the busy Floor schedule we have for the remainder of the year,” starts a letter from Representative Steny Hoyer, House Majority Leader. “In December … the House will vote on the MORE Act to decriminalize cannabis and expunge convictions for non-violent cannabis offenses that have prevented many Americans from getting jobs, applying for credit and loans, and accessing opportunities that make it possible to get ahead in our economy.”The MORE Act - Marijuana Opportunity Reinvestment and Expungement Act - includes language that would expunge some cannabis records and create grant opportunities for people who have been negatively impacted by the criminalization of marijuana in addition to removing it from its Schedule I classification.The act is sponsored by now-Vice President-elect Kamala Harris, and co-sponsored by seven other representatives including New Jersey Congressman Cory Booker and Massachusetts Congresswoman Elizabeth Warren.Senate Majority Leader Mitch McConnell is opposed to the act, and some say the odds of it passing the senate, even if it passes the House, are very slim.Marijuana is already legal in more than a dozen states, despite the federal designation as a Schedule I drug.Studies show more people support the legalization of marijuana. A 2019 Gallup poll showed majority-support across major political parties for legalizing marijuana. It showed 51% of Republicans, 68% of independents, and 76% of Democrats are in favor of it.During the November election, medical and recreational marijuana use was on the ballot in a handful of states. Four states, Arizona, Montana, New Jersey, and South Dakota, voted to make recreational marijuana use legal in their states. And Mississippi voters approved marijuana for medical use.Even if the MORE Act passes both chambers of Congress, it would not make sales of marijuana legal. Regulation of marijuana would be left to states to decide how to handle it. 2473

A large sports complex that was being used to shelter more than 5,000 migrants in Tijuana has been closed "due to health issues," according to Mexican officials.Pictures posted to the Facebook page of the Tijuana mayor's office showed officials with face masks cordoning off the entrance of the Benito Juarez Sports Complex on Friday.The complex, which had become Tijuana's main facility for sheltering migrants trying to reach the US border, was closed "due to the poor sanitary conditions," a statement from the office of Tijuana's mayor, Juan Manuel Gastélum read.CNN crews visiting the complex last week found squalid conditions, including open sewage drains.Rodolfo Olimpo, a representative from Baja California state's Special Committee on Migration Issues, told CNN last week the complex was more than three times over its capacity.Since Thursday, Mexican officials have been transferring migrants from the complex to a new shelter that is further away from the border in the eastern part of the city in an area known as El Barretal.Most of the migrants staying at the complex had left as of Sunday, but CNN crews there observed several dozen migrants staying in tents outside the gate. 1201

A fatal crash that closed the westbound lanes of I-696 near Detroit Tuesday involved a driver who ran out of gas on the side of the freeway. The Michigan State Police said a driver that ran out of gas was parked on the right shoulder. His father came to the scene to bring gas. As the driver was filling his tank with gas, and his father sat in his car with the child of the stranded driver, another driver on the freeway lost control and hit both vehicles. The driver filling his tank was pronounced dead at the scene. The driver of the car that lost control sustained minor injuries. MSP said the suspect driver is in custody and a blood draw was performed at a nearby hospital. There are no indications of alcohol or drugs at this time, said MSP. Speed does appear to be a factor, MSP said. The freeway reopened shortly before 5:30 p.m. 897