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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.
BEIJING, Dec. 31 (Xinhua) -- The Red Cross Society of China (RCSC) has decided to shut down one of its fund-raising groups due to serious management flaws, as the group's alleged misuse of donations sparked public mistrust in charities.The China Business System Red Cross Society has been repealed for failing to establish a sound internal management system, maintaining a benefit-based relationship with a consulting company, and committing violations in financial and legal management, an investigation report said Saturday.The China Business System Red Cross Society, a group founded in 2001 by the China General Chamber of Commerce (CGCC) with the approval of the RCSC, engaged in charity fund raising in the commercial sector. Funds raised by the group are channeled directly to the RCSC.The group faced accusations earlier this year of misusing charity money after a young woman calling herself "Guo Meimei" claimed online to be a general manager of "Red Cross Commerce" and posted pictures on her tweets detailing her lavish lifestyle.Netizens related "Red Cross Commerce" to the China Business System Red Cross Society, and speculated that Guo might have funded her purchases by embezzling money from the Red Cross.In July, the RCSC suspended all operations of the China Business System Red Cross Society and started an investigation along with officials and experts from the Ministry of Supervision, the Chinese Academy of Social Sciences, a law firm and the CGCC.According to the investigation report, "Red Cross Commerce" does not exist, and Guo Meimei is not employed by the China Business System Red Cross Society or its cooperative enterprises.The RCSC says it is preparing to set up a public supervision committee, and it plans to invite people from all walks of life, including influential figures, to supervise its use of donations as a third party.Meanwhile, the RCSC is also building up an online service that will publicize information about all donations made to the Red Cross system nationwide, in a move to safeguard the rights of the public, including donors, and supervise the charity group's operations.The website is expected to be launched by the end of 2012, the RCSC said.The RCSC has also vowed to strengthen the supervision and management of its subsidiaries and promote transparency in donations, financial management, tendering and procurement, and fund distribution and use.

BEIJING, Nov. 28 (Xinhuanet) -- Scientists in Canada have raised a prospect of reversing Alzheimer's disease by deep brain stimulation, according to media reports Monday.The technique here is known as deep brain stimulation -- applying electricity directly to regions of the brain. It has been used in tens of thousands of patients with Parkinson's as well as having an emerging role in Tourette's Syndrome and depression.The study at the University of Toronto took six patients with the condition. Deep brain stimulation was applied to the fornix -- a part of the brain which passes messages onto the hippocampus.Lead researcher Prof Andres Lozano said you would expect the hippocampus to shrink by five per cent on average in a year in patients with Alzheimer's.After 12 months of stimulation, he said one patient had a five per cent increase and another had an eight per cent increase.Prof Lozano told BBC: "This is the first time that brain stimulation in a human being has been shown to grow an area of your brain.""It was an amazing finding for us," he said.The findings were presented at the Society for Neuroscience conference in November but they have yet to be published in an academic journal.To test whether this is really working, rather than being a fluke result, the researchers are going to perform a larger trial.
WASHINGTON, Oct. 19 (Xinhua) -- A total of 25 people have been killed in 12 U.S. states in a listeria outbreak traced to Colorado cantaloupes, the U.S. Centers for Disease Control and Prevention ( CDC) said Wednesday.The number of people sickened by the tainted cantaloupes has reached 123 in 26 states, with Pennsylvania reporting its first case. One of the ill patients, a pregnant woman, suffered a miscarriage, the CDC said in a telebriefing.The listeria outbreak has been the most deadly one since 1998, according to the CDC.Listeria is a common bacterium that typically causes mild illness in healthy people, but can cause severe illness in older people and those with compromised immune systems. It also can cause miscarriages and stillbirths in pregnant women and severe infections in new babies.The CDC estimates that about 48 million people in the U.S. each year get sick from tainted food, with about 128,000 hospitalized and 3,000 deaths.
SAN FRANCISCO, Nov. 17 (Xinhua) -- Online retail giant Amazon is working on a smartphone scheduled to be released in the fourth quarter of 2012, U.S. media reported Thursday.A note from Citigroup analyst Mark Mahaney obtained by technology news site All Things Digital said that based on the supply chain checks in Asia, Amazon is believed to launch a smartphone in the fourth quarter of 2012.According to the note, Amazon is working with manufacturer Foxconn and the device will run Texas Instruments' OMAP 4 processor. The Kindle Fire, the latest tablet introduced by the e- commerce giant, also uses OMAP processor.The analyst said the smartphone will cost Amazon between 150 and 170 U.S. dollars to build and the company could sell the handset at or near its cost rather than a 30 percent gross margin like many other smartphone manufacturers usually do.The move is expected to further intensify Amazon's rivalry with Apple and Google after the e-commerce giant had made moves on some booming businesses like tablet computer and cloud-computing service.
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