太原屁股上长一个大疙瘩(太原做无痛胃镜多少钱一次) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- County health officials are notifying people who may have been exposed to tuberculosis at locations throughout San Diego County. According to County News Center, three unrelated cases of the disease were reported in San Diego County between August 20 and October 18. Two of the cases were reported at San Diego County Sheriff’s detention facilities. RELATED: Tuberculosis case confirmed at San Diego Airport, exposure risk extremely lowThe third case was found in a person who arrived from out of town after being diagnosed with TB and spent time at one of the city’s bridge shelters. Investigators believe the individual arrived in San Diego after leaving a Long Beach hospital without permission. The third person died from “co-occurring medical conditions” at a local hospital on October 6. The periods of exposure are listed below: Aug. 20 to Sept. 6, 2019 at the San Diego Central Jail Detention FacilitySept. 6 to Sept. 15, 2019 at the George Bailey Detention FacilityOct. 16 to Oct. 18, 2019 at the Las Colinas Detention and Reentry FacilityAug. 20, 2019 to Sept. 9, 2019 at the 16th St. and Newton Ave. bridge shelterThe sheriff’s department is offering free testing for its staff and all identified people in custody while the County Health and Human Services Agency is offering free tests to those who may have been exposed and have no medical provider. RELATED: Tuberculosis case reported at Southwestern CollegeThe agency is also working with the City of San Diego, the San Diego Housing Commission and the Alpha Project to notify people who may have been exposed. Tuberculosis is transmitted from person to person through indoor air during prolonged contact with the infected person. According to health officials, most people who are exposed don’t become infected. 1807

SAN DIEGO (KGTV) -- County Supervisors Wednesday sent a letter to Governor Gavin Newsom asking him to take a second look at San Diego, potentially allowing shuttered businesses to reopen amid COVID-19. In the letter, Supervisors Kristin Gaspar, Jim Desmond, and Councilmember Chris Cate of the sixth district said Newsom’s “one-size-fits-all approach to closing entire business sectors is misguided as evidenced by the many sectors in San Diego forced to close their doors again despite not having contributed at all to the rise in our local cases.”Supervisors also pushed the governor to give more control to local leaders and health officials. RELATED: San Diego Mayor Kevin Faulconer, other local leaders take action to keep restaurants open“It is time to give local control of this public health emergency to the elected leaders and clinical team closest to the people so that we can begin community specific healing based on local data,” the letter reads.The letter was sent after San Diego was added to the state’s watch list, forcing some businesses to halt indoor operations.Following the new rules, Mayor Kevin Faulconer signed an emergency executive order making it easier for restaurants to operate outdoors.RELATED: San Diego to close some businesses as COVID-19 cases spikeThe Poway City Council also voted to provide picnic tables to local restaurants in an effort to help businesses move outside.Read the full letter below: 1446

SAN DIEGO (KGTV) - Bringing the entire family out for a day at the fair can get expensive. That's why the San Diego County Fair has set up some sweet deals for families.The biggest deal offered is the fair's season pass, which gives guests admission on all 26 days for . Which means the savings start of day two for adults and day three for children and seniors.One discount many locals expect every year is right at the checkout line. Albertsons and Vons grocery stores will sell discounted tickets at for adults and for seniors and children. Customers must have a minimum purchase of .RELATED: What to know about 2018's San Diego County FairThe grocery stores are also selling tickets for fair days, which are held on June 1, June 2, and June 6. The Passport to Savings book also includes a free return ticket to the fair. The coupon books sell for ahead of time and regularly, and include an array of coupons to use inside and outside the fair.And of course, the fair's Pay One Price Ride Days returns, offering unlimited rides for a flat rate on June 6-7, 13-14, 20-21, and 27-28.There are a number of other ways to save on tickets: 1187

SAN DIEGO (KGTV) — Construction has started on Mission Valley's first public elementary school.The new preschool through 5th-grade campus at the corner of Via Alta and Civita Boulevard will serve residents living in the Civita residential development. Families living in the Mission Valley and Fashion Valley neighborhoods will also make use of the new school.The campus will feature classrooms with roll-up doors that open to the outside for 1st- through 5th-grade students; dedicated play areas for preschool, kindergarten, and 1st- through 5th-grade students; "makerspaces" for students; and an indoor-outdoor multipurpose facility.San Deigo Unified School District provided a virtual walkthrough of the campus here."With more significant growth planned in the area, we must prepare for the influx of new families and students," said Dr. John Lee Evans, Board of Education President. "This community deserves a quality neighborhood school."The campus will enroll up to 500 students and construction is expected to finish in spring 2022.The new school is funded through 2012's voter-approved Proposition Z bond measure, state schools facilities funding, and developer fees, according to San Diego Unified School District. 1231

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