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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A Black man has filed a lawsuit against a gas station in Portland, Oregon claiming he was prohibited from buying gas because of the color of his skin, according to multiple media reports.Dominique DeWeese says he asked the attendant for a gallon of gas in a container back in July. According to the lawsuit, DeWeese says the attendant declined and allegedly implied he did not want to give DeWeese an opportunity to set fires.In Oregon, an attendant is required by law to pump gas, it is not self-service. “He asked if I was a Black Lives protester, rioter, kinda smirked and said ‘I’m not giving you any gas,’” DeWeese told KGW8 about the July incident.Portland has seen countless nights of demonstrations this year. They started in May, following the death of George Floyd at the hands of officers in Minneapolis.After the attendant declined to give DeWeese gas, he got out his cellphone and started recording. During the recording, the attendant tells DeWeese there are fires happening around Portland, “they get a can of gasoline and they start the fire,” the attendant says.“So, are you picking and choosing who to sell gasoline to?” DeWeese is heard asking on the video. The attendant said he was.DeWeese explains why he needs the gasoline, saying it's to put in the mole holes on his property that is just up the block from the gas station.The attendant says he will only give DeWeese gas if he can put it directly into a car or lawnmower, not a gas can.“I'm just doing my part to keep down the fires in town,” said the attendant.The attendant was reportedly let go after DeWeese’s video was shared widely on social media.DeWeese’s racial discrimination lawsuit was filed last week and is seeking 0,000. 1721

A group of NFL owners are accusing Jerry Jones of "damaging the league."Jones, who owns the Dallas Cowboys, is locked in a bitter feud with the owners of other teams over NFL Commissioner Roger Goodell's contract extension.A lawyer for the NFL's compensation committee, which is responsible for negotiating Goodell's extension, sent a letter to Jones' attorney on Wednesday urging the Cowboys owner to support the committee and not "attempt to sabotage" its efforts.The letter, of which CNNMoney obtained a copy, said Jones' "antics, whatever their motivation, are damaging the league and reflect conduct detrimental to the league's best interests."The compensation committee is composed of six owners. All the other NFL owners also received a copy of the letter, which was first reported by The Wall Street Journal.Jones' lawyer didn't immediately respond to a request for comment late Wednesday. The Cowboys declined to comment.The language used in the letter follows reports that other owners are considering whether to strip Jones of his beloved Cowboys. On Tuesday, Jones dismissed the possibility as well as reports he had received a cease-and-desist warning from the committee earlier in the week."If somebody is asserting that, they are not knowledgeable about how things work in the NFL," he told a Dallas radio station.The letter is the latest development in a saga that has pitted Jones against many within the NFL, exposing deep divisions.Jones has questioned Goodell's leadership and his handling of players who protest racial injustice by kneeling during the National Anthem.He's also upset over Goodell's treatment of his star running back, Ezekiel Elliott, who was suspended six games earlier this season for domestic violence allegations.Despite his recent clashes with the league, Jones has had a lot to do with how things work in the NFL.Besides winning three Super Bowls and a spot in the Pro Football Hall of Fame, he helped Las Vegas and Los Angeles land NFL teams. And he was instrumental in securing the league's lucrative TV rights deal.But his threat to sue fellow members and the league may be a step too far.The letter sent on Wednesday said Jones is trying to "deliberately interfere" with the committee's work.Jones said he's fighting for transparency in the negotiations and wants all the owners to approve any deal with Goodell. He has said that "well over half" of owners agree with him. But all 32 owners agreed in May to give the compensation committee the power to decide whether to extend Goodell's contract, according to a league spokesman.The committee said in the letter that it has continued to keep owners informed.At one point, Jones was a non-voting honorary member of the committee, but was dismissed after he made his threat to sue.The letter referenced his dismissal and accused him of circulating old and misleading documents in his quest for transparency."Someone who is genuinely concerned 'that the owners know the truth about the negotiations' would not deliberately distribute such an outdated document ... or threaten to sue the league and its owners if he does not get his way," it said. 3170

A child in Galion, Ohio tested positive for meth on Sunday, just hours after trick or treating in the small town located between Columbus and Cleveland, WBNS-TV reported. According to the Galion Police, the boy is expected to make a full recovery after suffering a seizure. The boy reportedly was sickened after playing with fake teeth that were given to him while trick or treating. The boy's father reportedly said that the boy only had a few pieces of candy before getting sick. The Galion Police has not confirmed how the boy became sick from meth, and an investigation is underway. In the meantime, the police department has issued a warning to its residents. "We encourage parents to thoroughly check any candy your children may have received before they eat it," the Galion Police Department said. An expert on Halloween sadism, Joel Best, has previously said that intentional tainting of trick or treat candy is generally rare.“There is this fear out there, and it is terribly overblown,” Best said. “They are worried that some maniac will hand them a contaminated treat, and I can’t find any evidence that has ever resulted to a death or serious injury.” 1201

A federal court in Texas sentenced ice cream manufacturer Blue Bell Creameries to pay .25 million in criminal penalties for shipments of contaminated products linked to a 2015 listeriosis outbreak, the Justice Department announced Thursday.Blue Bell pleaded guilty in May 2020 to two misdemeanor counts of distributing adulterated ice cream products.The sentence, imposed by U.S. District Judge Robert Pitman in Austin, Texas, was consistent with the terms of a plea agreement previously filed in the case.“The results of this investigation reflect the determination of the Defense Criminal Investigative Service to hold companies that sell food products to the military accountable and ensure they comply with food safety laws,” said Michael Mentavlos, Special Agent-in-Charge of the DCIS Southwest Field Office. “The health and safety of our service members and their dependents are of paramount importance.”The .25 million fine and forfeiture amount is the largest-ever criminal penalty following a conviction in a food safety case.“American consumers must be able to trust that the foods they purchase are safe to eat,” said Acting Assistant Attorney General Jeffrey Bossert Clark of the Justice Department’s Civil Division. “The sentence imposed today sends a clear message to food manufacturers that the Department of Justice will take appropriate actions when contaminated food products endanger consumers.”According to the plea agreement, Texas state officials notified Blue Bell in February 2015 that samples of two ice cream products from the company’s Brenham, Texas factory tested positive for Listeria monocytogenes, a dangerous pathogen that can lead to serious illness or death in vulnerable populations such as pregnant women, newborns, the elderly, and those with compromised immune systems.Blue Bell directed its delivery route drivers to remove the remaining stock of the two products from store shelves, but the company did not recall the products or issue any formal communication to inform customers about the potential Listeria contamination.Two weeks after receiving notification of the first positive Listeria tests, Texas state officials informed Blue Bell that additional state-led testing confirmed Listeria in a third product.Blue Bell again chose not to issue any formal notification to customers regarding the positive tests. Blue Bell’s customers included military installations.In March 2015, tests conducted by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) linked the strain of Listeria in one of the Blue Bell ice cream products to a strain that sickened five patients at a Kansas hospital with listeriosis, the severe illness caused by ingestion of Listeria-contaminated food.At least three people in Kansas died as a result of the contamination, according to the CDC.The FDA, CDC, and Blue Bell all issued public recall notifications on March 13, 2015. Subsequent tests confirmed Listeria contamination in a product made at another Blue Bell facility in Broken Arrow, Oklahoma, which led to a second recall announcement on March 23, 2015.According to the plea agreement with the company, FDA inspections in March and April 2015 revealed sanitation issues at the Brenham and Broken Arrow facilities, including problems with the hot water supply needed to properly clean equipment and deteriorating factory conditions that could lead to insanitary water dripping into product mix during the manufacturing process.Blue Bell temporarily closed all of its plants in late April 2015 to clean and update the facilities. Since re-opening its facilities in late 2015, Blue Bell has taken significant steps to enhance sanitation processes and enact a program to test products for Listeria prior to shipment.This story was first reported by Anissa Connell at KXXV in Waco, Texas. 3865