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WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."
WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

BRUSSELS, Nov. 7 (Xinhua) -- China and Europe should strive to strengthen their cooperation for a win-win outcome in this era of profound changes, said a senior Chinese official here on Monday.Liu Yunshan, a member of the Political Bureau of the Communist Party of China (CPC) Central Committee, made the remarks during his keynote speech at the opening ceremony of the China-Europe High-Level Political Party Forum.Chinese President Hu Jintao has expressed a readiness to work for world economic recovery and strong, balanced and sustainable growth at the G20 summit in Cannes, France last week, said Liu, who is also head of the Publicity Department of the CPC.Liu Yunshan(Front, 3rd,R), a member of the Political Bureau of the Communist Party of China (CPC) Central Committee, attends the opening ceremony of the China-Europe High-Level Political Party Forum in Brussels on Nov. 7, 2011. The forum kicked off in Brussels on Monday.The forum would carry on with discussions on the new possibility and new measures of cooperation between China and Europe, which would add new spurs to their relations, said the Chinese official.Liu called for more cooperation for a win-win result and mutual respect for cultural differences between China and Europe, as well as a common effort to build an inclusive and open international system to face up to global challenges.Noting that China and Europe are stepping into a new stage of development for their ties, Liu expressed hopes that both sides further enhance their strategic mutual trust, "respect each other's core interest and major concerns and observe each other's development from a more objective perspective."Efforts should be made to promote their cooperation in trade, finance, environment protection, high-tech and new energy, and China and Europe should also work to cultivate new growth possibilities for their economic and trade cooperation, he said.They should in the meanwhile expand people-to-people exchanges and take the chance of their intercultural dialogue year in 2012 to build on their friendship, he added.Leaders from the European political parties said the forum offered chance for a key high-level dialogue for the political parties in China and Europe, which would play an active role for the exchanges and comprehensive development of the relations between both sides.
SAN FRANCISCO, Oct. 5 (Xinhua) -- Microsoft announced Wednesday that it will bring cable television content to its Xbox video game console over the upcoming holiday season, expanding the console into an entertainment hub.According to the company's press release, nearly 40 world- leading TV and entertainment providers such as HBO GO and BBC will stream their content through the Xbox Live service in more than 20 countries and regions.Users will be able to sift through shows online with the Kinect motion sensor device for Xbox 360 and Bing voice search, Microsoft said.To watch TV programs via Xbox as an alternate delivery system, customers have to already subscribe to the TV services and Microsoft's Xbox Live Gold service of 60 U.S. dollars per year."Today's announcement is a major step toward realizing our vision to bring you all the entertainment you want, shared with the people you care about, made easy," Microsoft said in the press release.Microsoft first entered the gaming console market in 2001 with the Xbox, the predecessor to the Xbox 360. The Xbox 360 currently competes with Sony's PlayStation 3 and Nintendo's Wii as the seventh generation of video game consoles.In June, Microsoft said 35 million people subscribed Xbox Live service around the world, spending an average of 60 hours a month playing games and watching movies and shows. Last year, the company integrated social networking features into Xbox Live, allowing users chat with each other while watching programs.
LAS VEGAS, the United States, Jan. 12 (Xinhua) -- One of the most revolutionary changes for consumers that may come out of this year's International Consumer Electronics Show (CES) will not be the electronic devices themselves, but the way they are charged.Instead of using traditional cords to power mobile phones, kitchen appliances, and even vehicles, exhibits showcasing wireless power technologies offer a glimpse into the future of how individuals can charge their devices without a plug or cord.Fulton Innovation, who develops and licenses its eCoupled intelligent wireless technology, demonstrated how the technology could be applied across a variety of usage cases at home and at work.At CES, the company announced that it is releasing its next generation wireless power solutions that incorporate near-field resonant magnetic induction, allowing devices to charge without actually touching a charging surface.Additionally, it will allow power to transfer through metal surfaces, a property which had previously been unsafe to use as a surface conductor for power.While the products with integrated eCoupled capabilities currently in the marketplace focus predominantly on smartphone charging surfaces, in part due to the low-power demands of these devices, the company said there will be more applications using this technology expected to come to market in the near future.A large part of the added production scale on the consumer level is due to the standardization of the industry.In 2010, the Wireless Power Consortium (WPC) announced the finalization of the "Qi" standard, enabling interoperability for wireless charging between a power-providing device and electronics receiving power.Currently, the Qi standard is only applicable for the wireless transmission of power up to five watts, and the WPC is undertaking steps to expand this standard to deliver up to 120 watts of power.This standardization enables technology designers like Fulton Innovations to create underlying IP designs and technologies that work across a number of OEMs.The WPC currently has over 100 member companies, including Fulton Innovation, Nokia, Samsung, Haier, and Huawei Technologies.Fulton Innovation also expects to add its eCoupled technology to cars, giving automobile manufacturers the ability to install integrated charging platforms for mobile devices without additional wires or cords.Chinese auto makers Geely, Chery, Chang'an, and Dongfeng were the first to showcase cars at a major auto show featuring Qi standard charging stations during the April 2011 Shanghai Auto Show.The WPC estimates that there will be approximately five auto manufacturers who will release cars with Qi-enabled charging capabilities either late this year or early next year.
来源:资阳报