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While much-needed rain falling in parts of Northern California could help firefighters battling the deadly Camp Fire, it could also prompt powerful mudslides and debris flow, adding to the devastation for communities that have already been ravaged by the flames.Authorities fear the showers -- even as they clear the choking smoke and help extinguish flames -- will trigger mudslides and floods in areas scarred by the Camp Fire, complicating the search for victims' remains. Rain could also pile on misery for people forced from their homes, some of whom are living in tent camps outside.Two weeks after the devastating fire started, 563 people are unaccounted for, Butte County Sheriff and Coroner Kory Honea said. Of the 83 killed in the Camp Fire, at least 58 of them have been tentatively identified as rescue crews sift through debris, searching for more remains.The rain could make the process of scouring through the ash and debris more complicated, and lead to treacherous conditions for firefighters, officials said.It has been raining on and off for the past several hours in the town of Paradise, which was wiped out by the fire. A flash flood watch remains in effect through Friday morning, CNN meteorologist Gene Norman said. 1247

WEST SENECA, N.Y. —From the running water to the statues and perfectly trimmed plants, Pam and Dave Hubert's backyard in West Seneca, New York, is a place the couple can sit back and relax.But last fall was anything but relaxing for the family."I had a lump in the right side of my throat that I've had many times from having sinus infections," explained Dave. "I went to the doctor and he said something's not right this time.""His words were: you have cancer," Dave said. "You're going to go through hell, but you're going to survive."Dave was diagnosed with throat cancer at the end of August. He had 35 radiation treatments and two rounds of chemo. After months of grueling recovery, he was cancer-free, and could finally sleep and eat again.Pam was by his side throughout it all."We said there's got to be other purpose here than us being sick," Dave said. "I didn't get sick to get sick. I got sick cause someone else needs us to help them get through this."As fall approached this year, Dave had one question for his wife."He said to me, 'do you plan on decorating the yard for the fall?'" Pam recalled. "And I said 'yeah I usually do.' And he said, 'I was hoping you would say that, because last year I just couldn't, I was too tired, too weak I just didn't enjoy it the way I wanted to enjoy it.'""I tried to be out here doing some work," Dave said. "But I was just so tired. I was just so exhausted from the treatment."Pam decided this year needed to be different, so she put out a call on Facebook to people she knew, and to strangers."If there's somebody you know battling cancer or survived cancer, or may have lost a battle to cancer, I would like to honor them," Pam said. "And if you have a pumpkin I'm happy to put it in my yard and we'll display it."That's when the pumpkins started showing up. They have names of patients who have fought cancer, and also messages to those who were lost to the disease. 1929

With a coronavirus vaccine still months off, companies are rushing to test what may be the next best thing: drugs that deliver antibodies to fight the virus right away, without having to train the immune system to make them.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. Vaccines work by tricking the body into thinking there’s an infection so it makes antibodies and remembers how to do that if the real bug turns up.But it can take a month or two after vaccination or infection for the most effective antibodies to form. The experimental drugs shortcut that process by giving concentrated versions of specific ones that worked best against the coronavirus in lab and animal tests.“A vaccine takes time to work, to force the development of antibodies. But when you give an antibody, you get immediate protection,” said University of North Carolina virologist Dr. Myron Cohen. “If we can generate them in large concentrations, in big vats in an antibody factory ... we can kind of bypass the immune system.”These drugs are believed to last for a month or more and could give quick, temporary immunity to people at high risk of infection, such as health workers and housemates of someone with COVID-19. If they proved effective and if a vaccine doesn’t materialize or protect as hoped, the drugs might eventually be considered for wider use, perhaps for teachers or other groups.They’re also being tested as treatments, to help the immune system and prevent severe symptoms or death.“The hope there is to target people who are in the first week of their illness and that we can treat them with the antibody and prevent them from getting sick,” said Dr. Marshall Lyon, an infectious disease specialist helping to test one such drug at Emory University in Atlanta.Having such a tool “would be a really momentous thing in our fight against COVID,” Cohen said.Vaccines are seen as a key to controlling the virus, which has been confirmed to have infected more than 20 million people worldwide and killed more than 738,000. Several companies are racing to develop vaccines, but the results of the large final tests needed to evaluate them are months away.The antibody drugs are “very promising” and, in contrast, could be available “fairly soon,” said Dr. Janet Woodcock, a U.S. Food and Drug Administration official who is leading government efforts to speed COVID-19 therapies. Key studies are underway and some answers should come by early fall.One company, Eli Lilly, has already started manufacturing its antibody drug, betting that studies now underway will give positive results.“Our goal is to get something out as soon as possible” and to have hundreds of thousands of doses ready by fall, said Lilly’s chief scientific officer, Dr. Daniel Skovronsky.Another company that developed an antibody drug cocktail against Ebola — Regeneron Pharmaceuticals Inc. — now is testing one for coronavirus.“The success with our Ebola program gives us some confidence that we can potentially do this again,” said Christos Kyratsous, a Regeneron microbiologist who helped lead that work.Regeneron’s drug uses two antibodies to enhance chances the drug will work even if the virus evolves to evade action by one.Lilly is testing two different, single-antibody drugs — one with the Canadian company AbCellera and another with a Chinese company, Junshi Biosciences. In July, Junshi said no safety concerns emerged in 40 healthy people who tried it and that larger studies were getting underway.Others working on antibody drugs include Amgen and Adaptive Biotechnologies. The Singapore biotech company Tychan Pte Ltd. also is testing an antibody drug and has similar products in development for Zika virus and yellow fever.“I’m cautiously optimistic” about the drugs, said the nation’s top infectious diseases expert, Dr. Anthony Fauci. “I’m heartened by the experience that we had with Ebola,” where the drugs proved effective.What could go wrong?— The antibodies may not reach all of the places in the body where they need to act, such as deep in the lungs. All the antibody drugs are given through an IV and must make their way through the bloodstream to wherever they’re needed.— The virus might mutate to avoid the antibody — the reason Regeneron is testing a two-antibody combo that binds to the virus in different places to help prevent its escape.Skovronsky said Lilly stuck with one antibody because manufacturing capacity would essentially be cut in half to make two, and “you will have less doses available.” If a single antibody works, “we can treat twice as many people,” he said.— The antibodies might not last long enough. If they fade within a month, it’s still OK for treatment since COVID-19 illness usually resolves in that time. But for prevention, it may not be practical to give infusions more often than every month or two.A San Francisco company, Vir Biotechnology Inc., says it has engineered antibodies to last longer than they usually do to avoid this problem. GlaxoSmithKline has invested 0 million in Vir to test them.Giving a higher dose also may help. If half of antibodies disappear after a month, “if you give twice as much, you will have two months’ protection,” Lilly’s Skovronsky said.— The big fear: Antibodies may do the opposite of what’s hoped and actually enhance the virus’s ability to get into cells or stimulate the immune system in a way that makes people sicker. It’s a theoretical concern that hasn’t been seen in testing so far, but large, definitive experiments are needed to prove safety.“As best as we can tell, the antibodies are helpful,” Lyon said.___Marilynn Marchione can be followed on Twitter: @MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 5919

While hundreds of families wait in agony to learn the fate of missing loved ones, officials gave a gut-wrenching forecast on the fate of California's Camp Fire:It's not even halfway done burning yet.Since the Camp Fire erupted 10 days ago in Butte County, it has killed 77 people, destroyed more than 9,700 homes and torched an area the size of Chicago.But the blaze probably won't be fully contained until November 30, according to Cal Fire, the state's forestry and fire protection agency."It is overwhelming, I don't have any word to describe it," Butte County Sheriff and Coroner Kory Honea said. "This is unprecedented. No one has had to deal with this magnitude that caused so much destruction and regrettably so much death."Meanwhile, displaced residents are in limbo. Many are in Chico, Butte County's most populous city, about 15 miles from ground zero of the disaster, the town of Paradise.Some evacuees are staying with friends and family. Others are in a tent city in a Walmart parking lot. On Sunday, those seeking a place to grieve trickled into the First Christian Church of Chico for a candlelight vigil.A sign in the church set an intention for the hourslong open memorial: "We will rise from the ashes."The Camp Fire is already the deadliest and most destructive wildfire in California history. And with 993 people still unaccounted for, officials fear the death toll could keep rising.Crews are combing the remnants of houses where all evidence of life has been wiped out by flames. Many of the searchers have lost their own homes and are looking for the remains of their neighbors.While the search for the dead and missing continues, thousands of firefighters are trying to control the blaze. As of late Sunday, the Camp Fire had seared 150,000 acres and was 65% contained. 1826

When 13-year-old Hania Aguilar?is laid to rest in North Carolina on Saturday her father will be nearly 3,000 miles away.The US State Department has denied a temporary visa for Noé Aguilar to travel from Guatemala to attend services for his teenage daughter, according to the father's attorney."I had hoped they would find it in their hearts to let me be there for my daughter's funeral," Aguilar told CNN in a brief phone interview Friday."It's very sad. She was my princess. She will always be my princess."Immigration attorney Naimeh Salem said US embassy officials in Guatemala denied the temporary visa on grounds that Aguilar "didn't have enough ties to his home country, Guatemala.""That is not true," she said. "He has family there and his own business." 774