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SAN DIEGO (KGTV) — Restaurants up and down 5th Avenue in the Gaslamp District are gearing up for yet another three days of crowded on-street dining.This upcoming weekend will see 24 eateries offering service on the asphalt, up from the original eight that participating during the launch on June 18. But as they bask in the opportunity, restaurants on surrounding streets are asking - what about them?"It's a ghost town, especially at night," said Patrizia Bronchi, who owns Operacaffe on Fourth Avenue. "I'm really scared to have to close the restaurant because it's not possible to go on like this."Bronchi says revenue at Operacaffe is down more than 70 percent. She depends on crowds from the Balboa Theater across the street and visitors to hotels and conventions. All of that is nonexistent amid the Coronavirus outbreak.Bronchi says she is happy that 5th Avenue restaurants are seeing the increased business, but that the crowds are not spilling over onto 4th Avenue. Michael Trimble, who heads the Gaslamp Quarter Association, says the group cannot also close 4th and 6th Avenues due to traffic concerns.However, he said the association wants to help with new marketing, decorative lighting and parklets - such as replacing some parking spaces with permanent outdoor dining areas. "We really are trying to do what we can to support all of the merchants in the Gaslamp Quarter," he said. On Thursday to Saturday, 5th Avenue will be closed from L to F streets to allow on-street dining. During the second weekend of July, the number of participating restaurants will expand to 27. 1595

SAN DIEGO (KGTV) - San Diego County Vector Control officials reported new signs Friday of the potentially dangerous disease tularemia on a trail in Sorrento Valley.Several batches of ticks trapped along Lopez Canyon Trail tested positive for the disease, also known as rabbit fever.The first group of ticks with the disease appeared last week, officials said.County officials posted warning signs for hikers. Vector Control will also expand tick trapping in the area.The best way for people to protect themselves from tick bites include insect repellent for humans and pets, and long-sleeved shirts and pants.Tularemia can be treated with antibiotics but it can be fatal. 679

SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) – Rain-slicked roads across San Diego County led to multiple crashes on local freeways early Tuesday morning. 134

SAN DIEGO (KGTV) - San Diego may be America's Finest City, but when it comes to parking around town, the experience is not always a pleasant one. "It's horrific," said Shadrach Vaughn the founder of Park Connect. Vaughn recently launched Park Connect in July. The company's goal is to help connect homeowners or businesses who have empty parking spots, with people who need them.The owner or business can list their spot on the Park Connect website, and select a daily, monthly or hourly rate. Giving the host the flexibility to decide what to charge for their spot. RELATED: Making It In San Diego complete coverage"One day I thought, like how about an Airbnb for parking?" Vaughn said. Sara Ghodsi, one of Park Connect users, has her empty spot listed for  an hour, a day, or 0 for the entire month. And in two months, she says she has made 0. "This spot is always open. I figured I might as well get some type of income coming in." Ghodsi said. As long as people continue to hit the beaches and streets of San Diego, Vaughn says, he will continue to help people fill their parking spots and their pockets. Vaughn said, "San Diego is expensive, right? So for anyone an extra 0 a month, 0 a month, I would like that. I'm just happy to be part of it."For more information on Park Connect, check out their website here. 1414