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BEIJING, August 1 (Xinhuanet) -- U.S. researchers have discovered a genetic mutation unique to African Americans that links to heighten their asthma risk, according to reports published on Sunday in the journal Nature Genetics.Researchers of University of Chicago found a gene, PYHIN1, and its variations may account for asthma risk in people of African descent. In their study, they examined data from nine previous genome-wide association studies, totaling more than 2 million single nucleotide polymorphisms in 3,246 asthma patients and 3,385 control patient, 1,702 patient-parent groupings, 355 family-based cases, and 468 family-based controls.In the study, the researchers found that between 26 percent and 29 percent of people of African-descent carried at least one copy of the gene. In particular, one polymorphism of the gene was 34 percent more likely found in African-American and Afro-Caribbean people with asthma. More interestingly, this variant of the gene is rarely found in Caucasian people and in Latino population, it was found in less than 5 percent.This new variant is part of a family of genes linked with the body's response to viral infections. It is thought to be involved in interferon signaling, which could influence the occurrence of asthma.The team stressed that each gene variant on its own plays only a small role in increasing asthma risk, but that risk could be multiplied when combined with other risk genes and with environmental factors.
WELLINGTON, June 7 (Xinhua) -- Scientists in New Zealand have developed a new drug to fight previously untreatable hypoxic cancer tumors, which form in areas of the body starved of oxygen.The researchers at the Auckland University have entered an agreement for the clinical development of CEN-209, which was developed over 10 years of research, said a statement from the university Tuesday.CEN-209 was designed to enhance the effectiveness of radiotherapy and chemotherapy in solid hypoxic tumors, which were resistant to standard cancer therapies, said the statement. In lung cancer patients for example, about half of tumors had hypoxic regions.The new drug worked by damaging the DNA of hypoxic cancer cells, while leaving normal, healthy tissues alone.CEN-209 was designed and created by researchers at the university's Auckland Cancer Society Research Centre (ACSRC), using computer models of drug transport within tumors to accurately predict the anti-tumor activity of the drugs."Our computer models of drug transport developed in-house allowed the synthetic chemists to test their design theories and considerably shortened the discovery process," said Associate Professor Michael Hay, who led the ACSRC research chemists."CEN-209 improves markedly on previous agents in this class in terms of its ability to penetrate tumors, and this is reflected by its improved activity in the laboratory, when combined with long or short courses of radiotherapy," said researcher Professor Bill Wilson.Under the agreement between the university's Auckland UniServices Ltd. and California-based Centella Therapeutics, Inc., a subsidiary of Varian Medical Systems, Inc., Centella will have exclusive rights to CEN-209, which it will develop and trial with Cancer Research UK.The work on CEN-209 is the culmination of a program initiated with funding from the U.S. National Cancer Institute, and more recently from the Maurice Wilkins Centre for Biodiscovery. Ongoing preclinical research on CEN-209 and a backup compound was funded by grants from the Auckland Medical Research Foundation, Genesis Oncology Trust and Health Research Council of New Zealand, said the statement.

BEIJING, Sep. 16 (Xinhuanet) -- Government incentives are important to pave a low-carbon road to economic growth, but companies that improve their industry models and technologies are the main players and also benefit receivers, noted officials and industry insiders at the Summer Davos forum held in Dalian on Sep 14."The most important thing is to have the right direction," said Gao Jifan, chairman and CEO of Trina Solar, a national leading solar panel manufacturer in China.According to Gao, new energy solutions such as solar power, is the "right direction" of future growth, although many deficiencies still exist today. "As long as we have the direction correct, we can succeed as last. But this also requires policies, technologies and investment," he said.Malini Mehra, founder and CEO of the Centre for Social Markets, a non-profit organization that promotes sustainability, said there are two ways in which the governments can support low-carbon businesses to continue along a "green" path."The first is to provide some means of recognizing their good work," she said. And the second is building a measuring system to "verify which company is actually doing well, not just talking about doing well".Preferential policies are only the foundation, said Gao. "We must have a good overall plan along with advanced technologies to bring value back to the investors."Gao envisions that most of the world’s families will have "zero-consumption" houses with energy supply and storage systems relying purely on solar power by 2020.Without grid limitations, the technology can be used everywhere in the world, especially in the less developed areas."The cost of solar technologies has been on the decline over the past few years because of policy incentives and innovations of companies around the world," said Gao.A solar panel producing one watt’s electricity cost in 2005, but now it is reduced to only .2 to .3, he explained."This is the result of technological innovations and large-scale manufacturing. And it makes us more confident to see the solar energy to become a major part of the energy system in the future."Being low-carbon also helps a company attract clients because it is the current fashion and customers are more likely to choose low-carbon products, noted Klaus Kleifeld, CEO of the US aluminum products maker Alcoa Inc."The generation that we recruit today has a very different social consciousness and standards," he said. "They want to see and only want to work for companies that are sustainable."
LOS ANGELES, June 3 (Xinhua) -- Eating earth may protect the stomach against toxins, parasites and pathogens, a new study suggests.To examine the possible benefits from eating earth, researchers at Cornell University analyzed reports from missionaries, plantation doctors, explorers, and anthropologists to put together a database of more than 480 cultural accounts of geophagy -- the eating of earth.The database includes as many details as possible about the circumstances under which earth was consumed, and by whom. The researchers could then use patterns in the data to evaluate each potential explanation.Studies in the database indicate that geophagy is common even when food is plentiful. Moreover, when people eat dirt they tend to eat only small quantities that are unlikely to fill an empty stomach.The database shows that geophagy is documented most commonly in women in the early stages of pregnancy and in pre-adolescent children. Both categories of people are especially sensitive to parasites and pathogens, according to the researchers.In addition, geophagy is most common in tropical climates where foodborne microbes are abundant. Finally, the database shows that people often eat earth during episodes of gastrointestinal stress.It's unlikely the intestinal problems are caused by the dirt itself because the type of clay people usually eat comes from deep in the ground, where pathogens and parasites are unlikely to contaminate it. Plus, people usually boil the clay before eating it.More study would be helpful to confirm the protection hypothesis, the researchers say, but the available data at this point clearly support it over the other explanations for eating earth."We hope this paper stimulates (more) research," said Sera Young, a researcher at Cornell University and the study's lead author. "More importantly, we hope readers agree that it is time to stop regarding geophagy as a bizarre, non-adaptive gustatory mistake.""With these data, it is clear that geophagy is a widespread behavior in humans ...that occurs during both vulnerable life stages and when facing ecological conditions that require protection."The study is appearing in the June issue of The Quarterly Review of Biology.
BEIJING, July 11 (Xinhuanet) -- The pace of China's import growth in June fell to its lowest level in 20 months as tightening monetary policies kicked in, resulting in the biggest monthly trade surplus this year, official statistics show.Import growth is expected to slow in the coming months, thanks to the broad impact of the tightening measures, before picking up in the last quarter, economists predicted.According to the General Administration of Customs (GAC), imports rose 19.3 percent, from a year earlier, to 9.7 billion, the weakest since November 2009.Exports rose 17.9 percent and despite this being the smallest increase since last December they reached a record high of 1.9 billion.The decline in import growth has led to a widening trade surplus, .3 billion in June compared to .1 billion in May. But in the first six months the trade surplus dropped 18 percent, year-on-year, to .9 billion."Import growth was weaker than expected, as imports for China's processing trade weakened and de-stocking in heavy industry continued," Wang Tao, head of China Economic Research at UBS Securities, said."Recent commodity price drops, including crude oil, also helped lower the import bill," she added.June's net imports of crude oil fell 12 percent from May to 19.43 million metric tons, the lowest since October, amid refinery maintenance and slowing energy demand, according to the GAC figures."Decelerating economic growth and tightening measures to soak up market liquidity have reined in import growth, but it is not a cause for worry," Li Wei, an economist at Standard Chartered Shanghai, said.The government is expected to announce economic growth data for the second quarter on Wednesday. Gross domestic product growth is widely predicted to slow from 9.7 percent for the first quarter."The slowdown in import growth will last two to three months or even longer due to both falling demand and possible commodity price drops," Li said.Zhong Shan, vice-minister of commerce, said recently that imports will slow down in the second half, citing the government's measures to cool the economy.The central bank has raised interest rates five times since mid-October, with the latest on July 7, and increased the reserve requirements for commercial banks, the amount they have to set aside, nine times since November. The consumer price index, a major gauge of inflation, surged to 6.4 percent last month, the highest in three years.Zhao Fudi, GAC spokesman, said in an online broadcast on Sunday that higher prices are increasing inflationary pressure, leading to a 14.7 percent gain in the overall price of imported commodities in the first half.Imports surged 27.6 percent year-on-year to 9.4 billion from January to June, as commodity prices rose during the first half. Exports increased 17.9 percent in June, down from 19.4 percent in May."This is because of weaker external demand" from developed nations, Wang said.Exports increased 24 percent, year-on-year, to 4.3 billion during the first half, but exports to both the United States and the European Union, China's two major trading partners, rose by only 16.9 percent."The slow recovery of the global economy and the European debt crisis have added uncertainties to export growth," Zheng Yuesheng, head of the GAC statistics department, said.Lu Zhengwei, chief economist at Industrial Bank, believes that the March earthquake and tsunami in Japan hurt China's exports."The disaster cut off China's imports of parts and components used for mechanical and electrical goods, leading to a decline in those exports" which make up a majority of China's exports, Lu said.As Japanese manufacturers resume full production, or come close to it, in September, China's exports will regain momentum, he predicted.Li Wei agreed. "China's exports keep pace with the global economic recovery. And growth will probably see a turnaround in September" when orders for the Christmas season are usually made, Li said.Many companies in China's coastal regions are far from optimistic, citing rising costs in labor and raw materials and yuan appreciation, as well as shrinking demand abroad.Han Jie, deputy director general of the department of commerce in Zhejiang province, said "exporters in Zhejiang have experienced a disappointing first half, and the second half will not be better".
来源:资阳报