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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).

BONN, Germany, June 17 (Xinhua) -- The latest United Nations (UN) climate talks ended here on Friday with no surprise -- some " technical issues" saw some progress, as delegates usually said, while major disagreements remained.The two-week UN climate negotiations have made "clear advances" on such issues as extending carbon trading mechanisms, climate fund management and slowing deforestation, Christiana Figueres, UN Framework Convention on Climate Change (UNFCCC) executive secretary, said at a closing press conference.Figueres said delegates from 183 countries stepped forward with a technology mechanism to boost global green technology sharing. The mechanism will include a Climate Technology Center and Network to establish a worldwide clean technology stakeholder community.As for the implementation of a comprehensive package of the Cancun summit last year, this Bonn session has "paved the way" for progress at the next UN ministerial-level climate conference, which is to be held in Durban, South Africa from Nov. 28 to Dec. 9, Figueres said."Strong convergence has emerged on how the Adaptation Committee will be governed, what its composition will be and what its specific role will be," she said. "This progress means that the Committee could be fully operationalized at Durban."The UN climate chief stressed that governments, business circles and civil society cannot solve issues related to climate change "in one meeting," and climate talks are "the most important " negotiations the world has ever seen."The Bonn meeting is practical, focusing on concrete issues. In general, the negotiating process is moving forward step by step and on the right track," Su Wei, China's chief negotiator, told Xinhua on Friday."Despite setbacks and reversals, parties are taking climate change seriously and are willing to promote the negotiations under the Bali Roadmap," he said. "In the past two weeks, contact groups are busy making informal consultations on various topics.""Admittedly, in some key areas, there is a gap among parties," Su said.During the meeting, many delegates and observers have complained that the pace of negotiation was unbearably slow, especially against the backdrop of a new warning from the International Energy Agency, which said the global energy-related carbon emissions rose to a record high in 2010 despite decade-long efforts on curbs.Experts said one of the main hurdles in current talks was still the old topic -- the fate of the Kyoto Protocol, the sole legally- binding pact on industrial countries' emission cuts set to expire at the end of 2012.The protocol, which binds 37 rich countries, has been crippled since Cancun, as Japan, Canada and Russia have clearly stated they would not extend the pact's second commitment period after 2012.The United States, which never ratified the treaty, said it would not accept any legal deal unless other major economies have similar emission constraints.The European Union (EU), the last major bloc that is open to the renewing of the Kyoto Protocol, said its supportive attitude should not be taken for granted. The EU said it would not unilaterally step up efforts on combating climate change if other nations are not willing to do the same.Meanwhile, developing countries insisted that the updating of the Kyoto Protocol remains "the very core issue" of current talks, asking rich nations to shoulder their historical responsibilities and preserve the pact as a major legally-binding instrument to tackle climate change.The Group of 77 and China, representing over 130 developing nations, have said that the renewal of the Protocol should be the priority for Durban.On Friday, Figueres said that "resolving the future of the Kyoto Protocol is an essential task this year and will require high-level political guidance.""By Durban, governments need to come forward with options that will be acceptable to all parties," she said, adding that high- level contacts are necessary to break the ice.She told reporters that environment ministers are due to meet in Berlin from July 3 to 4, known as a continuation of last year's ministerial-level informal talks held in the town of Petersburg near Bonn. Moreover, world leaders are due to discuss climate change on the sidelines of the UN General Assembly in September.Before the Durban summit, delegates have agreed to hold an additional round of climate talks in late September or early October, Figueres revealed.

CANBERRA, June 10 (Xinhua) -- Going to work when you are feeling sick can make you sicker in the long run, an expert told Australia's media on Friday.New Zealand sociologist Professor Kevin Dew from the Victoria University in Wellington, has assessed more than 40 papers about " presenteeism".He defined presenteeism as: "People that are turning up at work when they feel that they should be at home sick.""People feel compelled to go to work because someone else would have to take up the workload (and they have a) feeling of responsibility for not being able to care properly for patients (if they don't show up)," he told the Australia Associated Press on Friday.He said that evidence suggested people who go to work when they are sick can have long term negative effects on health and productivity.Evidence shows that presenteeism increases illness, including musculoskeletal pain, fatigue, depression, and serious coronary events. It also leads to exhaustion which, in turn, leads to more presenteeism.Prof. Dew said certain medical conditions like depression and migraine are also linked with presenteeism because they are not seen as legitimate reasons for absence.He has written an editorial in the latest issue of the British Medical Journal about his findings.

BEIJING, Sept. 2 (Xinhuanet) -- Insomnia costs average U.S. worker 11.3 days, or 2,280 dollars, in lost productivity each year, according to a new study published in journal Sleep.The total cost to the nation is 63.2 billion dollars annually, the study said.Researchers analyzed information about sleep habits and work performance from 7,428 workers taking part in Harvard Medical School's American Insomnia Study survey in 2008-09.As a result, 23.2 percent of the participants suffered insomnia, characterized by a hard time falling or staying asleep.Moreover, insomnia rates were 19.9 percent for those with less than a high school education and 21.5 percent for college graduates."We were shocked by the enormous impact insomnia has on the average person's life," said Ronald C. Kessler, a lead author and a psychiatric epidemiologist at Harvard Medical School."It's an underappreciated problem. Americans are not missing work because of insomnia. They are still going to their jobs but accomplishing less because they're tired," Kessler noted.Employers usually ignore the consequences of insomnia because it's not considered an illness resulting in workers' absenteeism.But the high cost of lost sleep identified in this study indicates that employers need to take it more seriously.

WASHINGTON, June 14 (Xinhua) -- Short sleep duration may contribute to the development or worsening of hyperactivity and inattention during early childhood, suggests a research abstract that was presented Tuesday at SLEEP 2011, the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC.Results show that less sleep in preschool-age children significantly predicted worse parent-reported hyperactivity and inattention at kindergarten. The sample consisted of approximately 6,860 children, and analyses controlled for gender, ethnicity and family income."Children who were reported to sleep less in preschool were rated by their parents as more hyperactive and less attentive compared to their peers at kindergarten," said lead author Erika Gaylor, senior researcher for SRI International, an independent, nonprofit research institute in Menlo Park, California. "These findings suggest that some children who are not getting adequate sleep may be at risk for developing behavioral problems manifested by hyperactivity, impulsivity, and problems sitting still and paying attention." According to the authors, attention-deficit/hyperactivity disorder (ADHD) is not generally diagnosed until the school-age years. However, the onset of developmentally inappropriate inattention, hyperactivity and impulsivity is often much younger. Sleep problems, particularly difficulty falling asleep and staying asleep, are frequently reported in children and adolescents with ADHD. However, the direction of causation, if any, has been difficult to determine. Longitudinal studies may provide a window into the direction of this complex relationship.Last year at SLEEP 2010, Gaylor reported that having a regular bedtime was the most consistent predictor of positive developmental outcomes at four years of age. Having an earlier bedtime also was predictive of higher scores for most developmental measures.

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