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This year has been, unique, to say the least, and the holidays will be different and maybe lacking some familiar comfort food from family. Taco Bell is bringing back a menu item to give fans warmth and tradition.Nacho Fries will be available at participating locations nationwide starting on December 24. This is the second time this year the item will be available.“In a year as difficult and uncertain as this one was, we know that consumers crave the comforts they love most. That’s why we’re excited to bring back Nacho Fries for our passionate fans to close out this year and kick off 2021 positively and deliciously,” said Nikki Lawson, Taco Bell’s Chief Global Brand Officer, in a press release.Nacho Fries first appeared on the Taco Bell menu in January 2018.The fries are seasoned with what Taco Bell refers to as Mexican spices and served with a side of nacho cheese sauce.Other new menu items will be available on Christmas Eve, including a nacho taco, cravings pack and a new bacon chalupa. 1010

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

TOWN OF DOVER, Wis. -- Authorities believe a woman who escaped from the Robert E. Ellsworth Correctional Center Thursday broke into a nearby home and stole a pickup truck. The escapee was identified as 36-year-old Christine Abel.The Racine County Sheriff's Office was alerted to a break-in at a home 2 miles away from the prison at around 9:30 p.m. Someone stole a 2007 black GM Sierra pickup with a registration plate of MZ1698. An hour later, the prison reported Abel missing during a head count.  522

Three years ago, Megan Yaeger bought her first professional camera.“It was like my first love. Ya know, when you pick it up and an angel chorus sings in the background,” Yaeger said.However, it wasn’t a purchase she had been planning for. She had been saving money to go to Disneyland and was forced to cancel due to all of the smoke from fires back in 2017. Yaeger says her lungs can’t handle smoke.“Remember kind of like back in school when they’d force you to run and you’d be really really out of shape? And you’d just be sitting there, kind of feeling like you’re dying? That’s what it feels like but you’re sitting there with the smoke and you can almost feel the particles going into your lungs and you just can’t get full expansion of your lungs and it’s the worst feeling," Yaeger said. She says her lungs are very weak because she lives with a connective tissue disease.“So like your whole body is made of connective tissue – your vascular system, your heart, your lungs, your joints, your eyes – and my body kind of chooses to attack all of it,” Yaeger said.Yaeger lives in a rural town in Utah. But with all the wildfires burning in the western U.S., she’s concerned about the smoke in the air.“Even like campfire smoke I can’t be around, so I can’t imagine people with my condition who are living like right next to the fires,” Yaeger said.It’s not just people with chronic conditions who can be impacted by prolonged exposure to wildfire smoke, especially during the COVID-19 pandemic. According to the CDC, people who currently have or who are recovering from COVID-19 may be at an increased risk of health effects from exposure to wildfire smoke due to compromised heart and-or lung function related to the disease.“We know air pollution exposure causes inflammation and cellular damage in our lungs, we know that air pollution just wreaks havoc on our lungs, and so all of this hints at wildfire smoke also doing the same,” said Erin Landguth, an associate professor with the Center for Population and Health Research at the University of Montana.She was the lead author in a study that looked at the delayed effect of small particles from wildfire smoke that gets into your lungs and irritates it. Her team wanted to understand how it may impact the following flu season in Montana.“We basically show that across these 10 years of data, after a bad fire season, one would expect to see three to five times worse flu seasons,” Landguth said.Landguth says this leads researchers to believe wildfire smoke could make people more susceptible to contracting the flu, but she says more in-depth studies need to be done to confirm that. COVID-19 is different from influenza, but considering COVID impacts the lungs, Landguth says there’s cause for concern as wildfires rage in several states.“The hypothesis that air pollution can act both as a carrier of the infection of COVID-19 and as a factor that can worsen the health impact of the COVID-19 disease has been a hot research topic,” Landguth said.Landguth emphasizes correlation doesn’t necessarily mean causation -- meaning higher flu numbers the same years as large wildfires doesn’t mean the wildfires cause worse flu seasons. However, she says they’re actively trying to learn more by expanding the study to other states. In the meantime, Landguth says vulnerable and sensitive groups should keep an eye on air quality alerts and stay inside with a proper air filter. Yaeger is doing exactly that.“Staying inside, and if I’m feeling really wheezy, doing a lot of breathing treatments and just listening to my body,” Yaeger said.No matter what comes her way, Yaeger says she chooses to remain optimistic.“When you’re faced with death so many times, you either have the choice to just be miserable, or find joy even in the smallest moments. It’s kind of almost a survival mechanism I think, optimism," she said. 3887

Thieves stole priceless royal artifacts in a daring raid on a Swedish cathedral before escaping by speedboat, police said.The thieves made off with crown jewels belonging to former Swedish monarchs Karl IX and Kristina from the Str?ngn?s Cathedral to the west of the capital, Stockholm, on Tuesday.Two crowns and a golden orb adorned with a crucifix were taken from the cathedral, which dates back to the 12th century, according to a police report. The items date from the early 17th century.A witness told Swedish media that he was eating lunch when he saw two people running toward a boat, which they sped away in.Police said several thieves were involved in the heist. They fled in an open-topped motorboat across the sea from the base of the church. Several police patrol boats as well as police helicopters joined a hunt for the perpetrators.The cathedral was placed on lockdown, CNN affiliate Expressen reported, and the search for the thieves continued on Wednesday."To a limited extent we are still looking for (them) both on the ground and at sea. We have no new findings so far," said Tor Sevelius, commanding officer at the police's management center.Police are investigating "any boat that may seem interesting," as the thieves may have switched to another craft, police spokesman Thomas Agnevik told Expressen.The three items stolen were part of the funeral regalia of the king and queen, and would have been buried with the monarchs, Christofer Lundgren, dean of the Str?ngn?s parish, told Expressen. They were later taken from the burial site and displayed to the public, he added.He said that while the items have monetary value, it pales in comparison to their significance to Sweden's cultural history."From our point of view, the material value is less important than the cultural history of these items. I do not see this as a theft from Str?ngn?s cathedral assembly. This is part of the national cultural heritage, this is a theft of Swedish society," Lundgren said.Police said they could not comment on the value of the items stolen.The cathedral was open to the public from 10 a.m., and the theft took place just before lunchtime. No one was injured or threatened during the robbery, Lundgren said.The heist has echoes of a daring robbery in Venice in January, when thieves mingled with other visitors to an exhibition before brazenly making off with gems from the Qatari royal collection.In that robbery, at least two people entered the Doge's Palace -- a popular tourist spot in Venice where a selection of Indian jewelry from the Qatari collection was on display to the public. One suspect acted as lookout while the other grabbed the jewels from a display case. 2696

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