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WASHINGTON, May 11 (Xinhua) -- Johns Hopkins University researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.The work, published Wednesday in the journal Science Translational Medicine, suggests that liver cells derived from so- called "induced-pluripotent stem cells (iPSCs)" could one day be used as an alternative to liver transplant in patients with serious liver diseases, bypassing long waiting lists for organs and concerns about immune system rejection of donated tissue."Our findings provide a foundation for producing functional liver cells for patients who suffer liver diseases and are in need of transplantation," says Yoon-Young Jang, assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. "iPSC-derived liver cells not only can be generated in large amounts, but also can be tailored to each patient, preventing immune-rejection problems associated with liver transplants from unmatched donors or embryonic stem cells." A microsopic view shows human embryonic stem cells in various stages of differentiation into liver cells in this photo taken at Stanford University and released by the California Institute for Regenerative Medicine, March 9, 2009iPSCs are made from adult cells that have been genetically reprogrammed to revert to an embryonic stem cell-like state, with the ability to transform into different cell types. Human iPSCs can be generated from various tissues, including skin, blood and liver cells.Although the liver can regenerate in the body, end-stage liver failure caused by diseases like cirrhosis and cancers eventually destroy the liver's regenerative ability, Jang says. Currently, the only option for those patients is to receive a liver organ or liver cell transplant, a supply problem given the severe shortage of donor liver tissue for transplantation. In addition, mature liver cells and adult liver stem cells are difficult to isolate or grow in the laboratory, she says. By contrast, iPSCs can be made from a tiny amount of many kinds of tissue; and the embryonic stem- like iPSCs can grow in laboratory cultures indefinitely.For the study, Jang and colleagues generated human iPSCs from a variety of adult human cells, including liver cells, fibroblasts ( connective tissue cells), bone marrow stem cells and skin cells. They found that though the iPSCs overall were molecularly similar to each other and to embryonic stem cells, they retained a distinct molecular "signature" inherited from the cell of origin.
RIO DE JANEIRO, March 25 (Xinhua) -- The number of dengue fever cases in Rio de Janeiro city this year has already surpassed 10,000, local health authorities said on Friday.According to the city's Health Secretariat, in less than three months, the number of confirmed dengue fever cases in Rio reached 10,158, exceeding the figures registered in the entire years of 2009 (2,723) and 2010 (3,120).In Rio de Janeiro state, the number of confirmed dengue fever cases reached 20,150, and the death toll rose to 18.This week, the first two cases of type-4 dengue fever in Rio de Janeiro state were confirmed in the city of Niteroi. The type-4 dengue fever is not more dangerous than the other types, but as the disease had not been registered in the region before, the local population has no immunity to it.As there are four different types of dengue fever, a person can develop the disease several times.The last epidemic of dengue fever in Rio de Janeiro state occurred in 2008 when 174 people died of the disease and some 250,000 cases of dengue were registered.

MOSCOW, May 13 (Xinhua) -- The main and backup crews that will fly to the International Space Station in June have passed preflight tests and are ready for space travel, the Russian Cosmonauts Training Center said Friday.The main crew includes Russian cosmonaut Sergei Volkov, Japanese astronaut Satoshi Furukawa and American astronaut Michael Fossuma.A Russian spaceship Soyuz TMA-02M will send the crew to the space station on June 8, Interfax news agency reported.The backup crew includes members from Russia, the Netherlands and the United States.The crews were tested on the various emergency situations they could face during the flight.Next Monday, the commission will make a final choice of crewmembers for the launch.The crew will spend 161 days in orbit and conduct three space walks.
LIMA, May 5 (Xinhua) -- A total of 53.5 million people in Latin America and the Caribbean suffer from hunger or malnutrition, experts said at an international forum here Thursday.Juan Garcia, coordinator of the 5th work-group meeting of the Latin American and Caribbean Initiative Without Hunger, said the figure has not increased since 1990.Experts and officials from 13 countries gathered to discuss the challenges facing regional food security and advances that have been made, hoping to make cooperative efforts to eradicate hunger and malnutrition by the year 2025.Carcia said people affected most across the continent are still those living in rural areas as well as African descendants and indigenous people who suffer from "exclusion and inequality."The main cause of undernutrition is not lack of food-production capacity, but access to food, Carcia said.Six countries, Brazil, Ecuador, Venezuela, Guatemala, Honduras and Nicaragua, have approved food security laws with nine more in the process of doing so. The laws are considered as a way to ensure that local agricultural products are primarily used to feed the countries' own populations and not used for export.
LOS ANGELES, May 11 (Xinhua) -- U.S. researchers have found MRSA (methicillin-resistant Staphylococcus aureus) in meats sold at U.S. supermarkets, according to a study published on Wednesday.This is "community-acquired MRSA" that is transmitted by humans carrying the bacteria, researchers at Wayne State University in Detroit reported in the study appearing in the May 11 online edition of the U.S. Centers for Disease Control and Prevention's ( CDC's) journal Emerging Infectious Diseases.For the study, the researchers purchased 289 raw meat samples, including 156 beef, 76 chicken and 57 turkey samples, from 30 grocery stores in Detroit from August 2009 through January 2010.The researchers found that 22.5 percent of the samples were contaminated with S. aureus and six samples tested positive for MRSA.Of the six samples contaminated with MRSA, two were beef, three were chicken and one was turkey, the researchers said.The extent of MRSA contamination in meat varies by the type of meat and where the meat was processed, said lead researcher Yifan Zhang, an assistant professor in the department of nutrition and food science at the university.The germ is apparently being introduced by humans handling the meat, she said.According to another recent study, the strain of MRSA in meat in the United States is not the strain found in animals, Zhang noted."MRSA has always been found in human patients, but we found this in retail meat, so retail meat can be a reservoir of these bugs," said Zhang."When people handle food, they can get the bugs from the meat if the meat is already contaminated," she explained.The risk of becoming infected is especially high if you have open cuts or sores on your hands or skin, Zhang added.MRSA is common in hospitals and nursing homes, where it can cause serious illness and even death.But recently "community-acquired MRSA" has become a problem among some high school and college athletes who share equipment.This type of MRSA appears as a skin infection and is usually less serious, according to CDC.MRSA is killed when the meat is cooked thoroughly, experts say.Other precaution measures include:-- Wear gloves when handling meat, especially when there are wounds on the hands;-- Washing plates or utensils used to prepare food before using them again to eat; and-- Disinfect counters that have come into contact with meats.
来源:资阳报