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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) — Construction began Friday on SeaWorld's next big attraction for the park, billed as California's tallest, fastest, and longest dive coaster.The first phase on the dive coaster started in conjunction with National Roller Coaster Day, as crews prepared the coaster site for the ride's foundation and utilities. The coaster will be located adjacent to the park's Journey to Atlantis attraction in the southeast corner of the park.SeaWorld previously said the ride would be called "Mako," after the endangered species of shark. Now, the park says the name is up in the air with several options being considered, City News Service reported.RELATED: SeaWorld San Diego offers end-of-summer saleThe coaster will climb 153 feet, leaving riders' feet dangling in the air. At the crown of the attraction, riders will be suspended on a 45-degree angle before diving 143 feet at more than 60 miles per hour. For two minutes, riders will zip through inversions, a barrel roll and Immelmann loop, hammerhead turn, and flat spin along 2,500 feet of track. Each car will hold 18 riders in three, six-person rows.Aquatic education will play a role in the attraction as well. SeaWorld plans to partner with a conservation group to focus on the ride's conservation efforts.Switzerland-based Bolliger & Mabillard, which built SeaWorld Orlando's Kraken and Mako rides, will construction the San Diego coaster.SeaWorld plans to open the coaster to the public in 2020. 1476

py the city of Berkeley in passing a law that allows activists to rescue animals in distress, like cows and chickens, from slaughterhouses.“It’s a big step to stop everyone to stop eating animals, so they’re not going quite that far,” says one demonstrator. “But what they’re trying to do is at least give those animals the right to be rescued.”San Diego Police arrived on scene and tried negotiating with the chained protesters to get them to leave. After 45 minutes, San Diego Fire-Rescue and other resources came in. The chains were cut and the protesters were taken into custody.“We want to make sure that everyone involved is safe and that no laws are broken,” says Capt. Mike Holden with SDPD. “In this case, we gave plenty of notice, and unfortunately, we had to effect for arrest.”Police say it is permissible to protest on the property but it is against the law to impede the flow of business.Shortly after the arrests, those who were not taken into custody held a rally outside City Hall. Organizers would like for San Diego leaders to implement rules locally that will endorse Rose’s law, which is an animal bill of rights.Rose’s law extends the rights of animals, like those found on a farm, to free, not owned; to not be exploited, abused or killed by humans; to have their rights represented in court; and the right to be free.City leaders are currently not taking up the issue. 1761

SAN DIEGO (KGTV) -- Authorities responded to a riot Friday night at Richard J. Donovan Correctional Facility in Otay Mesa that left five people injured, including at least one with serious injuries.Cal Fire San Diego said about 100 inmates were in the prison yard when a fight broke out around 8 p.m. California Department of Corrections and Rehabilitation said Saturday that number was closer to 80 inmates.CDCR said officers gave multiple orders to stop fighting, before using several rounds of less-than-lethal force to stop the incident.Four inmate-made weapons were recovered, CDCR said.Five inmates were injured and had to be transported outside the prison for treatment, for injuries including puncture wounds, cuts, and bruises to the head, neck, and torso areas, CDCR says. Cal Fire had previously reported that six inmates were transferred from the scene.One of those inmates suffering from puncture wounds was in critical condition. Three inmates were in fair condition and the fifth was treated and returned to prison, CDCR said.No prison staff members were injured.The facility canceled visitation for Facility A Saturday and Sunday in light of the riot. 1175

SAN DIEGO (KGTV) - Businesses are bracing for Governor Gavin Newsom's announcement Monday after San Diego has been on the state's watch-list since July 3, due to a surge in coronavirus cases.Newsom could announce indoor activities, like arcades, restaurant dining, movie theaters and museums will be shut down to contain the spread.This news comes as San Diego restaurants faced a volley of changes over the past four months."I think that the only thing that is constant is the change," Chief Brewing Officer Mike Hess said from his Imperial Beach brewery.He said the lucky thing about most of his locations is they have outdoor space, so they can shift more easily. "I called everybody Friday when we got word when it might change on Monday and everybody was like ‘Okay what do we need to do?’" He said sighing.READ RELATED: Mike Hess Brewing Company serving up a different type of alcoholSome of the changes he's made to be compliant with health orders have come at quite a cost. He said in one pay period his labor costs at the Imperial Beach location are three times the norm because they switched from bar service to table service and have to sanitize more often.Across town at Small Bar, Owner Karen Barnett said they shut down at the beginning of July and don't have any plans to reopen.'At the end of the day a business is a business, people are more important.' Barnett said they have been doing take out since the beginning of the pandemic, but never reopened for dine in.She said the small space at her business and horror stories of other restaurants and bars dealing with enforcing social distancing, wearing a mask and employees testing positive with the virus, helped her stick to her guns.On Friday, she posted this on Instagram, "After much consideration, Small Bar will be closing for the entire month of July (possibly longer). When the global pandemic was declared almost 4 months ago, we decided to quickly switch gears and continue to serve our community as thoughtfully and safely as possible. Unfortunately, Americans both near and far don't seem to be listening as closely to science as we are. We no longer deem our services "essential". We care about our community and feel the best move right now is to take a step back for a few weeks. In the meantime, we will be working on our footprint and how we can safely reopen later. We encourage more businesses to follow our lead to help flatten the curve, yet again. We will be working on ways to serve with as little contact as possible, but until that time we wish you all health and peace in the world. Take care."Monday we will find out if all restaurants will have to shut down inside dining, and wait at least three weeks until reopening. 2725

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