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That hurdle is attributed to the fact that in order to start naltrexone, a person has to have detoxed or not used opioids for several days, whereas a user can transition from opioids to buprenorphine seamlessly. "If you're currently opiate-dependent ... (naltrexone) takes more work," said Dr. Joshua Lee, the lead author of the study, who studies opioid addiction behavior and treatment at New York University. 416

Speaking an event sponsored by the Bill and Melinda Gates Foundation, he quipped the Paris agreement was a "small agreement to save the planet." 144

The "Happiest 5K on the Planet" returns to Mission Valley. Runners will dash through stations outside SDCCU Stadium as they're hit with foam and brightly colored dust. The run benefits the Break the Silence Against Domestic Violence organization. More information. 274

Tatis Jr., 20, is expected to be the team’s starting shortstop and will wear No. 23 -- a number previously donned by former Padres star and Chula Vista native Adrian Gonzalez. 175

The 298-acre overall project will eventually include a performing arts center, hotels, parks, retail shops, restaurants and residences. It's being developed by Rams owner Stan Kroenke. 184