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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.
BEIJING, Jan. 22 (Xinhua) -- China restored 23,000 hectares of wetlands in 2011, according to the latest figures from the State Forestry Administration (SFA).An SFA spokesman said China reinforced wetland protection in 2011 by increasing subsidies in protecting wetlands. In the year the country carried out 42 wetland protection projects, increased 330,000 hectares of protected wetland areas, added four wetlands of international importance and 68 national wetland parks.The spokesman said in 2012 the country will further step up wetland protection and restoration, finish the second national wetland resources investigation and carry out pilot projects in assessing healthy conditions of the wetland ecological system.So far China has built more than 550 wetland natural reserves, 37 wetlands of international importance, which were listed in the Ramsar international wetland convention, and 100 national wetland parks. About half of the country's natural wetlands have been brought under effective protection, the SFA said.

HELSINKI, Nov.23 (Xinhua) -- Nokia Siemens Networks is planning to cut its workforce by 17,000 worldwide by the end of 2013, the company said in a statement on Wednesday in Espoo, Finland.The company said the measures are part of an extensive global restructuring program, in which it will focus on mobile broadband and services."We need to take the necessary steps to maintain long term competitiveness and improve profitability in a challenging telecommunications market," said the company's Chief Executive Rajeev Suri in the statement.Rajeev Suri called the job cuts regrettable but necessary, and said the company would provide support for individuals and communities affected by the cuts, but defended the decision on economic grounds.Nokia Siemens is aiming to cut operating expenditures by around a billion euros over two years.Some 74,000 people currently work for the Espoo-based company in 150 countries, around 7,000 in Finland. The company will announce the geographical distribution of the job cuts later on.
BEIJING, Jan. 6 (Xinhua) -- China will bring its nurse population to 2.86 million by 2015, meaning there will be 2.07 nurses for every 1,000 people, according to a blueprint on nursing issued Friday by the Ministry of Health (MOH).By the end of 2010, China has registered 2.05 million nurses and there were 1.52 nurses for every 1, 000 Chinese.Even by 2015, the ratio of registered nurses for 1,000 people in China is five times fewer than countries in the European Union and the United States by current standards.By 2015, the ratio of licensed doctors to nurses will climb from 1:1 to 1:1.2, according to the blueprint.China also plans to provide more training for head nurses in large hospitals and make nursing services accessible to households and communities, according to the blueprint.The five-year nursing development plan said the government will further standardize its nurse management system and deepen health care reform in public hospitals over the next few years.The total number of registered nurses reached 2.05 million in 2010, marking a 52 percent jump from 2005, according to the blueprint.
WINDHOEK, Nov. 29 (Xinhua) -- An agreement on Economic and Technical Co-operation was signed here on Tuesday between the Chinese and Namibian governments.The agreement was signed after Namibian Cabinet ministers and officials from various ministries held talks with Chinese State Councilor Liu Yandong, who arrived in Namibia on Tuesday for a three-day official visit.Minister of Presidential Affairs Albert Kawana, who is the Acting Director-General (DG) of the National Planning Commission (NPC), and Ambassador of China to Namibia Wei Ruixing signed the agreement.The two also exchanged letters on the provision of office supplies and solar energy equipment to the Namibian government by the Chinese government.During their talks, Liu highly spoke of the steady, healthy development of the relations between the two countries.She said the substantial cooperation have been obtained on agriculture, mining and human resources. Great achievements have been made in exchanges of culture and education.The state councilor also said China would like to work together with all African countries including Namibia to promote the development of people-to-people exchanges.Namibia's Deputy Prime Minister Marco Hausiku proposed future cooperation with China in visual and performing arts.He said the Directorate of Arts in the Ministry of Youth, National Service, Sports and Culture is keen to develop future relationships that will lead to bilateral exchanges in arts education, assistance in the development of small arts businesses, the promotion of arts through the exchange of information on arts and participation in events in the respective countries."This can be achieved through the development of ties between the relevant institutions responsible for these areas, such as the line ministries responsible for arts, arts education colleges, performance theaters, art galleries and organizers of events such as festivals and expos," he noted.He also encouraged exchanges between musicians in the sphere of composition, conducting, and instrumental playing in both folklore and symphonic genres, and therefore invited China in the development of Namibia's National Symphony Orchestra.Hausiku also proposed for scholarships in information and communication technology (ICT), particularly policy development and regulatory framework, and linkages with Chinese ICT institutions for exchange purposes.
来源:资阳报