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WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."
BEIJING, Dec. 17 (Xinhua) -- Senior Communist Party of China (CPC) official Zhou Yongkang has called for efforts to promote a police campaign aimed at better addressing public complaints.Zhou, a member of the Standing Committee of the Political Bureau of the CPC Central Committee, made the remarks in a written instruction on the campaign launched by the Ministry of Public Security on Friday.During the six-month campaign, police will be sent to more households to settle disputes and complaints or help solve public problems. The public will also be invited to supervise the work of the police, according to the ministry.Zhou said he believed the campaign would cement ties between the police and the masses and called on police to build a positive image for themselves during the initiative.The desirable "positive image" would only be possible by promptly addressing those most-attended security issues, said Meng Jianzhu, minister of public security, at Friday's launching ceremony.Meng urged his fellow police officers to make solid progress in enhancing the public's sense of security through this campaign.Police services on household registration, exit & entry, traffic and fire fighting were specifically mentioned by Meng, which were instructed to be strengthened or improved.
LAS VEGAS, the United States, Jan. 12 (Xinhua) -- NVIDIA, the computer chip manufacturer best known for its high performance graphics processors, is looking to make further inroads with the automobile industry by integrating its new Tegra 3 mobile processors in upcoming vehicle models.At the 2012 International Consumer Electronics Show (CES), NVIDIA and Audi announced that all models from the German auto manufacturer in 2013 will use Tegra 3 quad-core processors to power their in-car digital systems.These processors, which are traditionally found in smartphones and tablets, will support the vehicle's digital systems at lower energy rates and also allow for shorter lead times in getting concepts to market.In addition to powering infotainment systems that allow for web browsing and Google Earth integrations, they will also give automakers the ability to replace traditional dashboards with instrument cluster systems, or digital dashboards."By leveraging technology from the very latest smartphones and tablets, Audi is leading the market with innovations that enhance safety and make driving more enjoyable," said Ricky Hudi, the company's chief executive engineer, at Audi's official conference at CES.For Audi, this means that they will be able to offer cars like the next-generation A3 model beginning in 2013, which features an integrated touchpad system and mounted monitor with the ability to render 3D imaging. Current 2012 Audi vehicles house the Tegra 2 processor."It's a natural progression with people getting so accustomed to mobile and expecting it from your automobiles as well. Partnering really closely with automotive OEMs enable us to help them realize the driver experience they're looking to deliver," said Phillip Hughes, NVIDIA's director of automotive sales and business development, in an interview with Xinhua.In addition to Audi, Tesla and Lamborghini will also be including the newest NVIDIA Tegra 3 processor in upcoming models. At this year's CES, Lamborghini is showcasing the Lamborghini Aventador, a nearly 700 horsepower vehicle with the capability of going from 0 to 60 miles per mile in less than five seconds."NVIDIA technology is enabling us to do more with our vehicles and gives our cars the ability to have the technology you'd expect from a car like this," said Kelly Snyder, an event manager with Lamborghini, to Xinhua. The retail price point for the Lamborghini Aventador starts at 382,000 U.S. dollars.More than just powering the car's digital experiences, however, integrating NVIDIA's processors will help the auto manufacturer build better cars by reducing the power to weight ratio that is a key consideration in manufacturing higher performing cars."By moving elements like the odometer to a digital dashboard platform, it reduces the power to weight ratio that is so critical to the design and manufacturing of automobiles like the Lamborghini," explained Snyder.NVIDIA also expects that the integration of these processors will bring the development cycle of the automotive industry up to speed with the consumer electronics industry through Virtual Computing Modules (VCMs) powered by the Tegra 3. These VCMs allow auto manufacturers to quickly prototype and ship consumer technology innovations to automobiles, reducing a development lifecycle that once took seven years, to roughly a year."At the end of the day, our goal is to help automotive OEMs bridge the gap between OEM and consumer technology," said Hughes.
BEIJING, Jan. 5 (Xinhua) -- Chinese media organizations on Thursday unveiled the top 10 domestic and international news events of 2011.The selection of news events, the eighth of its kind in China, was jointly carried out by 46 major online media providers, including people.com.cn and Xinhuanet.com.The following are the top 10 domestic news events of 2011:-- China launched a series of tough government measures to cool off the property market, including higher mortgage rates, a ban on third-home mortgage loans and purchase restrictions. The State Council, or China's Cabinet, introduced a policy package urging enhanced efforts to ensure the healthy development of the property sector and to promote the construction of affordable housing units for low-income families.-- More than 90 central government departments publicized their 2010 and 2011 spending on government-funded overseas travel, receptions and official cars upon an order issued after an executive meeting of the State Council in May.-- China's amended Criminal Law criminalized all drunk driving incidents starting May 1. The previous law imposed criminal penalties on drunk drivers only when they caused serious traffic accidents.-- Food safety scandals erupted in great number in 2011. Authorities busted farmers for adding clenbuterol, a known carcinogen, to pig feed in order to grow leaner pigs.-- In a speech delivered on July 1 at a ceremony marking the 90th founding anniversary of the Communist Party of China (CPC), Hu Jintao, general secretary of the CPC Central Committee, hailed the Party's achievements and stressed efforts for the future development of the country and the Party.-- On July 23, a high-speed train rammed into a stalled train near the city of Wenzhou in the eastern province of Zhejiang, leaving 40 dead and 191 injured.-- The launch and safe return of the Shenzhou-8 unmanned spacecraft marked the successful completion of China's first space docking mission, with the spacecraft docking with the Tiangong-1 space lab module.-- A gathering was held on Oct. 9 to commemorate the 100th anniversary of China's 1911 Revolution, which ended 2,000 years of imperial rule in the country by toppling the Qing Dynasty.-- The 17th Central Committee of the CPC concluded its sixth plenary session in October, adopting a landmark guideline for improving the nation's cultural soft power and promoting Chinese culture. The CPC Central Committee also pledged enhanced efforts to promote the healthy and positive development of Internet culture.-- Ethics and morality were heavily discussed in the public sphere, with two incidents stoking debate. In July, a woman in east China's city of Hangzhou caught a two-year-old girl who plunged from the window of a 10th-floor apartment, winning praise from people across the country. However, in late August, a bus driver in east China's Jiangsu province stopped to save an old woman who was hit by a three-wheeled vehicle, only to find himself held accountable for the accident.The following are the top 10 international news events of 2011:-- Strong turbulence was encountered by several countries in western Asia and northern Africa.-- On March 11, a 9.0-magnitude earthquake struck Japan and triggered a huge tsunami, killing over 15,000 people and causing radioactive leaks from several reactors at the Fukushima Daiichi nuclear power plant.-- On May 1, U.S. Navy commandos killed al-Qaida leader Osama Bin Laden in a cross-border raid at Abbotabad.-- On July 10, Rupert Murdoch's News International company closed its News of the World tabloid after it was accused of hacking the mobile phones of dead crime victims to access saved messages.-- With the world economy staggering under the European and U.S. debt crises, the Occupy Wall Street movement was launched on Sept. 17, protesting corruption and greed in the financial sector.-- Apple co-founder and longtime Chief Executive Officer Steve Jobs passed away in October at the age of 56 after years of fighting pancreatic cancer.-- On March 19, NATO launched airstrikes in Libya to impose a no-fly zone under a UN Security Council resolution. On Oct. 20, Libya's former leader Muammar Gaddafi was killed as his hometown of Sirte fell to rebel forces.-- A report published by the UN Population Fund showed that the world's population reached 7 billion on Oct. 31, 2011.-- On March 7, U.S. credit rating agency Moody's Investors Service downgraded the credit rating of the Greek sovereign debt to B1, marking the start of the European sovereign debt crisis and worsening the economic situation in the eurozone.-- Kim Jong Il, the top leader of the Democratic People's Republic of Korea (DPRK), died on Dec. 17, 2011 from "a great mental and physical strain."
COPENHAGEN, Nov.23 (Xinhua) -- Denmark's new tax on fatty foods is having little impact on consumer habits, an opinion poll showed Wednesday.Only seven percent of those polled said they had changed their shopping habits since the tax was imposed Oct.1, said FDB Analyse, which conducted the poll for Danish news agency Ritzau.The world's first fat tax affects products containing more than 2.3 percent saturated fat, meaning a kilo of saturated fat costs 16 Danish kroner (2.87 U.S. dollars).As a result, butter, cream, cheese, meat, cooking oil and processed foods like pizza and biscuits are among thousands of products that have become dearer in recent weeks.However, two out of three respondents to the poll said price rises are too low to make them alter their dietary habits, an opinion shared by some in the food retail sector."Price rises per product vary from a few oere to 2 kroner (0.36 U.S. dollar)," said Mogens Werge, Director of Consumer Policy at Coop, a supermarket chain which accounts for 40 percent trade in basic daily goods in Denmark."No Danes will change their dietary habits just because the cost of a packet of cookies rises by 35 oere," he told DR News, Denmark's public broadcaster.The Danish Agriculture and Food Council, an industry association, says the fat tax costs a Danish family with two children an additional 1,000 kroner (180 dollars), per year.Reacting to the poll, the Social Democratic Party (SDP), which leads Denmark's coalition center-left government, said the fat tax must be given more time to take effect."There are several parameters to measure the tax, one of which is purely economic, where you have to consider a longer time period," SDP consumer affairs spokesperson Mette Reissmann, told DR News."Also, I never thought we would suddenly become a nation that rejects fatty foods. It takes a long time to change consumer behavior," she added.The government's Commission on Prevention, tasked with finding ways to improve the nation's health, also said it is too early to evaluate the fat tax's impact. It believes the tax discourages purchase of unhealthy foods, and will help raise average Danish life expectancy by one week.For their part, two-thirds of poll respondents suggested the government would do better by removing value added tax (VAT) on healthy foods like fresh fruit and vegetables, and instead raise it on food products containing fat and sugar.Denmark already imposes 25 percent VAT on most consumer goods and food products.