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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The weekslong search for Mollie Tibbetts, a 20-year-old Iowa student who disappeared while jogging, came to a grisly end Tuesday when a man guided investigators to a body in a cornfield.While authorities have yet to confirm the body is Tibbetts, they arrested Cristhian Bahena Rivera, 24, on first-degree murder charges.The discovery dashed the hopes of family and friends who had scoured Poweshiek and nearby counties as rewards grew to nearly 0,000. Tibbetts, officials said, is believed to have been abducted on July 18 as she went out for an evening jog.Rivera, who's an undocumented immigrant, told them Monday that he saw and pursued her, getting out of his car and running beside Tibbetts. She warned him she would call police, officials told reporters Tuesday.The suspect, who said he blacked out at some point, led authorities to the field Tuesday morning, they said. A body, dressed in Tibbetts' clothing, was covered in corn leaves.It is unclear why Rivera killed Tibbetts, said Rick Rahn, special agent in charge at the Iowa Division of Criminal Investigation."I can't really speak to you about the motive," Rahn said. "I can just tell you it seems that he followed her and seemed to be drawn to her on that particular day and for whatever reason he chose to abduct her." 1294

The Trump administration is promising one of the largest fireworks displays in recent memory in Washington on July Fourth. It also plans to give away as many as 300,000 face masks to those who come down to the National Mall for the festivities, although they won't be required to wear them. This is despite concerns from D.C. Mayor Muriel Bowser, who warns that the plans run counter to established health guidelines. Interior Secretary David Bernhardt on Wednesday detailed President Donald Trump's plans for Independence Day in the nation's capital and said they include a mile-long detonation of 10,000 fireworks. Trump and first lady Melania Trump plan to host events on Saturday from the White House south lawn and from the Ellipse.Additionally, military planes will conduct flyovers in a handful of major cities along the East Coast as part of this year’s July Fourth celebration. The Pentagon says roughly 1,700 service members will support a salute to the “Great Cities of the American Revolution.” The flyovers will begin in Boston and proceed to New York City, Philadelphia and Baltimore. Washington has held an Independence Day celebration for decades, featuring a parade along Constitution Avenue, a concert on the Capitol lawn with music by the National Symphony Orchestra and fireworks beginning at dusk near the Washington Monument.President Donald Trump plans to kick off Independence Day festivities with a showy display at Mount Rushmore the day before. When he speaks at the Mount Rushmore, he’ll stand before a crowd of thousands of people who won't be required to socially distance or wear masks despite the coronavirus pandemic. The event will include fighter jets thundering over the 79-year-old stone monument in South Dakota’s Black Hills and the first fireworks display there since 2009.Public health experts are warning of the risk that it could help the coronavirus to spread. And others say the fireworks will put the forest around the monument at risk to wildfires. 2003

The U.S. will pay more than billion for 100 million doses of a potential Covid-19 vaccine manufactured by Johnson & Johnson.The deal is one of several large agreements between the government and pharmaceutical companies as part of Operation Warp Speed, aimed at creating, testing, manufacturing and distributing a Covid-19 vaccine quickly.The Trump administration’s deal with Johnson & Johnson, announced Wednesday, allows for the purchase of an additional 200 million doses.Johnson & Johnson’s vaccine, developed by subsidiary Janssen Pharmaceutical Companies, has shown positive preclinical results. Testing of their vaccine is currently underway with human trials in the United States and Belgium.The Johnson & Johnson vaccine testing is reportedly behind some of the more advanced-stage potential vaccines, like those from Moderna, Pfizer and AstraZeneca, which have begun phase three human trials.“We greatly appreciate the U.S. government’s confidence in, and support for, our R&D platform and efforts and the scalability of our vaccine technology. We are scaling up production in the U.S. and worldwide to deliver a SARS-CoV-2 vaccine for emergency use,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson in a statement.The company says they are committed to global access to the vaccine following approvals, and has a goal of supplying 1 billion doses globally through the end of 2021. 1493

The U.S. population grew by the smallest rate in at least 120 years from 2019 to 2020.Figures released Tuesday by the U.S. Census Bureau show the U.S. population grew by 0.35% from July 2019 to July 2020, an increase of 1.1 million people in a nation with an estimated population of more than 329 million residents.Demographer William Frey says population growth in the U.S. already had been stagnant over the past several years due to immigration restrictions and a dip in fertility.However, the pandemic exacerbated that lethargic-growth trend.Even during the height of the Spanish flu, the growth rate was higher — 0.49%. 632

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