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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617
SAN DIEGO (KGTV) - It’s a great time to buy a used car. “These deals are once in a lifetime,” said Ivan Drury, a used car expert with Edmunds. Amid the uncertainty caused by the coronavirus pandemic, used car prices have been decreasing. According to Bloomberg News, the average price of a used car fell 11.4% from March to April. Drury predicts those prices could continue to fall, as desperate rental car companies start to offload unused inventory. Hertz, which filed for bankruptcy on Friday, has a fleet of about 500,000 vehicles. It’s unclear what their plan is for them, but Drury suspects they will only keep enough to maintain a basic level of service. “That influx of used vehicles will have a dramatic impact on price,” he said. Adding to the supply of used cars, Drury predicts that some drivers who have leased cars will hold on to them for a few more months rather than trade them in. But in several months to a year, he expects that could lead to another flood of used vehicles. “You kind of have a perfect storm for used car values to drop even further,” said Drury. 1090

SAN DIEGO (KGTV) - Jessica Reilly, a Navy Air Traffic Controller currently based out of San Diego, has a high-stress job, but turns to her artistic side as an outlet. She combines her passion for the Navy with creating comics, adding a little bit of Dungeons and Dragons (which she learned from her husband) to create Gobbo the Goblin, a Navy sailor.“I have managed to breed a comic series for the Navy that is also targeted toward Dungeons and Dragons players,” she said, laughing.She said she’s loved art since she was a child, and started drawing her first comics on whiteboards while aboard Navy ships. It’s grown from there. She has a cartoon version of herself that goes on adventures with Gobbo. She said her real-life experiences combined with stories from other sailors motivate the storylines, frequently making fun of the daily woes of Navy life.“There is an outlet and a want for people to see comics kind of tongue and cheek of their own culture,” she said.She said this comedic relief is a good mental break from a tense job.“My job, even though it’s stressful, especially as an Air Traffic Controller, I can take a break, and I can remind everybody else that it’s not so stressful,” she said.Her art has turned into a family business. Her husband, who is a Navy veteran and currently in the Army reserves, writes comic books and she illustrates them. She said the first time they teamed up, they brought the comic books to a show and they sold out on the spot. Their company, Five Realms, was supposed to have a table at Comic-Con, which was canceled this year. To win a spot at the show, they had to submit their comic book, which was reviewed by judges. “It’s a huge accomplishment for me and my husband and unfortunately it didn’t happen,” she said, adding that they hope to be there next year.Jessica’s work has been noticed by the Navy. She’s been selected to do an Instagram takeover of the Navy’s “At the Helm” page during the week of October 25. She’ll have the chance to showcase her art and talk about her work and company.“The fact that people can message me and say my work makes them happy, it makes it all worth it, it makes it beyond worth it,” she said.Her Instagram page is @ZonksIllustration. 2234
SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617
SAN DIEGO (KGTV) — Just as he begins his campaign to become San Diego's next mayor, Assemblymember Todd Gloria was fined for violating the Political Reform Act.According to the California Fair Political Practice Commission, Gloria, "failed to timely file a Candidate Intention Statement prior to receiving contributions to his candidate-controlled committee, Todd Gloria for Assembly 2020."The FPPC fined Gloria 0. They say Gloria paid that fine.RELATED: Poll: Gloria pulls early lead in San Diego mayoral raceSan Diego, at last, has Republican candidate for mayorSan Diego's top Democratic mayoral candidates square off in debateAccording to the California Secretary of State's website, before raising any campaign funds, state candidates file "Statements of Intention" to run for a specific office. Candidates can file Statements of Intention for more than one office.Gloria's signed statement of intention shows the state received it on Aug. 13, 2019. That's after the campaign committee was opened and filed a "Recipient Committee Campaign" statement.In August, officials with the California Fair Political Practices Commission told 10News Gloria called FPPC Enforcement and self-reported.A spokesman for Gloria said they look forward to the final resolution of the matter: "Assemblymember Gloria agreed to this settlement to resolve any and all outstanding issues regarding the filing of his Form 501."Earlier this week, Gloria tweeted he officially pulled nomination papers to run for Mayor of San Diego in 2020, writing, "I'm ready. Let's do this." 1566
来源:资阳报