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SAN DIEGO (KGTV) — Regulators at the Food and Drug Administration said they found no red flags that would stand in the way of authorizing Pfizer’s COVID-19 vaccine on an emergency basis.FDA scientists independently confirmed Pfizer’s claim that its vaccine is 95 percent effective after two doses and said they found no serious safety concerns, according to documents released Tuesday.The FDA released the 53-page review ahead of a meeting this week by an outside group of vaccine experts that will advise the agency and vote on whether to recommend an emergency use authorization for the drug in people 16 and older. A San Diego doctor will be among the 30 voting members.Government regulators examined the vaccine’s efficacy in subgroups and found it remained highly effective regardless of age, gender, race and risk factors. The vaccine scored 91 percent or better in nearly every way the agency sliced the data.“The news is really outstandingly good in terms of efficacy,” said Dr. Christian Ramers of Family Health Centers of San Diego. “It’s kind of almost a dream come true to have something that's 90 percent efficacious. If you recall, the FDA was shooting for better than 50 percent.”Among adults who were aged 65 or older and obese, one of the highest risk groups for severe COVID-19, the vaccine was 100 percent effective. That means no one who got the vaccine got sick, only volunteers in the placebo arm who got salt water.Dr. Peter Chin-Hong, an infectious disease expert at UC San Francisco, noted that most influenza vaccines are between 40 and 60 percent effective. “So getting 90 percent and above in some groups is just staggering,” he said.Pfizer’s vaccine is administered in two doses staggered three weeks apart. The FDA’s review began providing protection after 10 days, and just one dose reduced cases by 52 percent.That could spark discussion about how to allocate scarce doses in countries with limited access; however, Dr. Chin-Hong said there are too many unknowns to skip the second shot.“We don't know how long that protection would last,” he said. “Given the history and experience with other vaccines, we know that you get a more durable level of antibodies after a second shot.”The FDA also examined side effects in detail. Regulators found the majority of people who got the vaccine experienced some kind of mild to moderate side effect that resolved within a few days. A moderate side effect interferes with, but does not prevent, daily activity.According to the data, 84 percent of recipients had a reaction at the injection site, 63 percent felt fatigue, 55 percent had a headache, 38 percent experienced muscle pain, 32 percent had chills, 23 percent had joint pain and 14 percent had a fever.“These are things you expect from a vaccine. It actually means that it's working,” Dr. Ramers said. “That’s your immune system learning from that vaccine how to fight that bad virus.”Because of the mechanics of how Pfizer’s mRNA vaccine trains the body to build an immune response, there is no way the vaccine can cause COVID-19, he noted. The vaccine does not contain actual virus or viral particles.The FDA also looked for signs of any serious side effects in the trial of 44,000 volunteers. The agency noted there were four cases of temporary facial paralysis called Bell’s palsy in the vaccine group and none in the placebo group.Despite the apparent imbalance, the FDA scientists noted the numbers were so small the cases could have been caused by something other than the vaccine. In a large group of people, a certain number of cases of Bell’s palsy are expected to occur because the disorder can be caused by several pathogens.The number of cases in the vaccine group did not exceed what regulators call the background rate, meaning the number of cases that would be expected to occur in the general public.Bell’s palsy is temporary and treatable. Actress Angelina Jolie announced in 2017 she experienced a bout of Bell’s palsy and fully recovered. 3997

SAN DIEGO (KGTV) — San Diego County started the rainfall season in October bone dry, but now the region is getting ready for another storm in time for Thanksgiving.San Diego's weekend will be great, cooling down on Monday before the storm arrives. Winds will pick up on Tuesday. Then, the surf will increase along the coast before the Thanksgiving storm arrives.The atmospheric river will potentially set up the stage for heavy rain, flash flooding, and thunderstorms during the major winter storm. Rainfall totals could average from 3-5 inches for the coast and valleys and 4-8 inches in the mountains. Snow levels will start out high around 8,000 feet. RELATED: Today's 10News weather forecastHere's how you can keep your pets safe with the cold weatherCold air will settle in Friday with snow levels dropping to 3,500 feet. That means snow could fall in Julian, Palomar, Mt. Laguna, and even Descanso. The best chance for snow will be Thursday and Friday.The chance of rain will begin late Tuesday, lasting through Thanksgiving Day and Black Friday. Often times San Diego is the envy of the nation, especially during the holiday. The region's warmest Thanksgiving happened in 2017, hitting 87 degrees. Last year the holiday took a chilly turn, plunging down to 58 degrees — just 4 degrees shy of San Diego's coldest Thanksgiving in 1919. Last year, San Diego also picked up 0.04 inches of light rain. The wettest Thanksgiving in San Diego's history received 1.26 inches in 2008, but the expected winter system this week could challenge that record.Traveling this ThanksgivingThe expected wet weather is especially important to consider, as this holiday expects to see the highest Thanksgiving volume on record for California travelers. The holiday will also be the second-highest travel volume nationally since 2000, according to the Automobile Club of Southern California.AAA says about 7 million Americans will be traveling 50 miles or more this Thanksgiving. Of that number, about 4.3 million are from Southern California.Of those Southern Californians, 3.7 million will travel by car, 500,000 by aircraft, and 123,800 will use other modes of transportation, like buses or cruise ships.RELATED:AAA provides tips on preparing vehicles for holiday travelTSA offers advice to travelers for Thanksgiving holiday weekendWith the influx or drivers, thousands of expected to run into problems on the road, according to AAA. The Auto Club says about 100,000 Californians and 368,000 nationwide will need roadside assistance for things like flat tires, dead batteries, or lockouts."This is the fourth Thanksgiving holiday period in a row that the percentage growth in air travel for Californians is higher than the growth in car travel, indicating continued consumer confidence in spending more for holiday trips," said Auto Club spokesperson Jeffrey Spring. "That's despite an average 7 percent increase in airfares over last year."AAA says the top five destinations for Southern California residents will be Las Vegas, San Diego, Mexico (cruises and resorts), the Grand Canyon and Lake Tahoe. 3099

SAN DIEGO (KGTV) -- Residents in San Ysidro and Tijuana are fearful of what will come next after hundreds of migrants rushed the border Sunday in a show of force.Commuters told 10News they fear that they won’t be able to get across a bridge in San Ysidro to work or cross over to see family.In Mexico, residents say they’re fed up with the flood of migrants. “Deport them back to where they are, let them over here. They need to get out of Tijuana because it's just crazy for us,” said Candace Sanchez, a Tijuana resident.On the US side, those with family south of the border are concerned with what the future holds. “It worries me that the border might get closed. I mean it's like uh what's going on? We've never really seen this before,” said Victor Juarez.Employees who depend on their jobs in the US are also frightened. “Kinda scary because you know, I mean, every day we just know that we have to do what we have to do every day just to survive,” said Dana Aviles.Many people missed a day of work due to Sunday’s border closure, taking a toll with the holiday gift-giving season approaching. “I just hope they get out of here in Tijuana and let our lives be normal again, you know,” added Sanchez. 1213

SAN DIEGO (KGTV) — San Diego is filled with foodie fun, music, and chances to learn about San Diego's humble beginnings this weekend.The City Heights Street Food Festival brings a taste of City Heights flavor and live music to town, while the America's Finest BBQ Championship is boasting the country's best pit-master creations this weekend.KAABOO Del Mar hits the Del Mar Fairgrounds with an all-star lineup, and the South Bay Pride Art & Music Festival brings multiple stages of music and talented arts to Bayside Park.MORE: Don't see anything you like? Check out our event calendar for even more local eventsWhen you're in Old Town or Old Poway Park, enjoy a look at San Diego's beginnings during Founders Day Old Town or the Train Song Festival in Poway.Here's a look at this weekend's events:THURSDAYCity Heights Street Food FestivalWhere: Fair@44; Cost: Free - Enjoy a taste of City Heights flavor with a side helping of live music and art, beer and wine, and spoken word performances. And, of course, delicious foods representing cuisines from around the world.Two Scientists Walk Into a BarWhere: Various locations; Cost: FreeEnjoy a frosty craft beer and a chat with a scientist on their field of study during the Fleet Science Center's Two Scientists Walk Into a Bar event. Several breweries will host scientists that are experts in a variety of fields, including molecular and cellular biology, neuroscience, oceanography, and much more.FRIDAYKAABOO Del MarWhere: Del Mar Fairgrounds; Cost: Starting at 9(Friday - Sunday) KAABOO Del mar returns with an awesome lineup of acts including Kings of Leon, Dave Matthews Band, Mumford & Sons, and many, many more. Plus, stand-up comedy from Wayne Brady, Kevin Smith, Bob Saget, and others, and a lineup of amazing art exhibits and delicious food to match.San Diego BayfairWhere: Mission Bay Park; Cost: - (Friday - Sunday) Enjoy a weekend on the bay during San Diego Bayfair's family-fun festival of boats, beach party, action sports and boat racing, live music, and more. SATURDAYFiestas Patrias! Mexican Independence DayWhere: Old Town Historic Park; Cost: FreeHead out to Old Town to help commemorate Mexico's Independence Day, with the ringing of the historic Casa de Estudillo bell, historic and traditional music and dancing, crafts, games, demonstrations, and more that takes visitors back in time to Old Town's early years.South Bay Pride Art & Music FestivalWhere: Bayside Park; Cost: FreeLive entertainment, food and drinks, local art, and more await at the South Bay Pride Art & Music Festival. Multiple stages of music will help you get your groove on and Art in the Park will display the creativity of some of San Diego's most talented artists. A children's area will also be set up with inflatables, bungee jumping, and more!Moon FestivalWhere: Organ Pavilion, Balboa Park; Cost: FreeBalboa Park's House of China hosts an all day Moon Festival, highlighting the rare Harvest Moon this weekend. Head down to the park to enjoy cultural performances, an international show, and delicious cuisine from around the globe in honor of the fall season and as a way to give thanks.SUNDAYOld Town Founders DayWhere: Old Town Chamber of Commerce; Cost: Free(Saturday - Sunday) Old Town celebrates 250 years of San Diego with a free event for the public, commemorating Old Town's founding with cultural entertainment, fun activities, craft vendors, and more.America's Finest BBQ ChampionshipWhere: Crown Point Park; Cost: Sink your teeth into the most delicious BBQ eats around at the America's Finest BBQ Championship during San Diego Bayfair. As you sample world-class BBQ, enjoy local craft brews, live music, vendors, and boat racing on the bay.Train Song FestivalWhere: Old Poway Park; Cost: FreeRelax with a day filled with live music, train rides on a restored 1907 Baldwin steam locomotive, and more in Old Poway Park this weekend during Train Song Festival. 3959

SAN DIEGO (KGTV) — San Diego Gas & Electric has warned about 2,700 customers in several East County communities of potential public safety power shutoffs starting Friday morning.The utility company said outages may occur due to a red flag warning issued by the National Weather Service and the need to reduce wildfire risk in the areas. The affected communities include:AlpineCampo ReservationCrestwoodDescansoJulianLa Posta ReservationManzanita ReservationPalaSanta YsabelSanta Ysabel ReservationValley CenterViejas Reservation"The last thing we want to be telling any of our customers right now is that we may have to shut off power given the Thanksgiving holiday weekend and the ongoing COVID pandemic," said SDG&E’s Chief Customer Officer Scott Crider. "Public Safety Power Shutoffs are a last resort to prevent wildfires, and our employees are dedicated to doing everything we can to minimize impacts should it come to that. We’re hoping Mother Nature cooperates, but in an abundance of caution we have reached out to our customers so they can be prepared."SDG&E says several hundred linemen, troubleshooters, and support personnel will be working on Thanksgiving Day and through the holiday weekend to monitor the grid.The red flag warning will be in effect from 9 p.m. Thursday through 9 a.m. Saturday for San Diego County's inland valleys and mountains. Moderate strength Santa Ana winds are expected in areas of the backcountry. The strongest winds are forecasted to arrive on Friday.To see what communities may be impacted by any public safety outages, SDG&E has a list online. 1611

来源：资阳报