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Pfizer announced Friday that it would submit a request to the FDA Friday for its COVID-19 vaccine to be granted Emergency Use Authorization.Earlier this week, Pfizer said that a final analysis of trial results showed the vaccine is 95% effective.“Our work to deliver a safe and effective vaccine has never been more urgent, as we continue to see an alarming rise in the number of cases of COVID-19 globally. Filing in the U.S. represents a critical milestone in our journey to deliver a COVID-19 vaccine to the world and we now have a more complete picture of both the efficacy and safety profile of our vaccine, giving us confidence in its potential,” Dr. Albert Bourla, Pfizer Chairman and CEO, said in a press release.Pfizer's two-shot vaccine has already been in mass production for months, and thousands of doses will be ready for delivery if and when the FDA grants authorization. Pfizer says that is on track to produce 50 million doses of the vaccine by the end of 2020 and plans to produce 1.3 billion doses of the vaccine in 2021.According to "Operation Warp Speed," the federal government's plan for distributing the vaccine, upon authorization, the drug will initially be rationed for high-risk populations and health care workers. Dr. Anthony Fauci, the nation's top infectious disease expert, says he believes a vaccine won't be widely available until April.On Wednesday, Pfizer announced that a final analysis of its vaccine candidate showed that of 40,000 participants who participated in the trial, 170 people had contracted the virus. Of those 170 people, 162 received only a placebo injection — meaning just eight out of the 20,000 people who actually received the vaccine contracted the virus.The company added Wednesday that there have been no safety concerns with the vaccine. In a randomized survey of 8,000 participants, only 2% reported suffering severe fatigue, and only 4% reported suffering severe headaches. Those who say they suffered side effects only experienced them briefly after vaccination.Pfizer's announcement comes as COVID-19 cases are spiking around the world. In the U.S. alone, about 2.5 million people have contracted the virus in the month of November alone. Hospitalizations linked to COVID-19 are at an all-time high, and deaths have begun to tick up in recent weeks. 2322

PARADISE, Calif. (AP) — Authorities searching through the blackened aftermath of California's deadliest wildfire have released the names of about 100 people who are missing, including many in their 80s and 90s, and dozens more could still be unaccounted for.As the names were made public, additional crews joined the search, and the statewide death toll climbed Wednesday to at least 51, with 48 dead in Northern California and three fatalities in Southern California."We want to be able to cover as much ground as quickly as we possibly can," Butte County Sheriff Kory Honea said. "This is a very difficult task."Nearly a week after the blazes began, California Gov. Jerry Brown and Interior Secretary Ryan Zinke toured the area.RELATED: Third person found dead in Woolsey?FireBrown said he spoke Wednesday with President Donald Trump and that the president pledged "the full resources of the federal government.""The natural world is the power, and we create a lot of comfort and we create a lot of security," Brown said. "But at the end of the day, we are physical beings in a biological world."Zinke said many factors contributed to the blazes. He urged people not to "point fingers" and focus on moving forward.A sheriff's department spokeswoman, Megan McMann, acknowledged that the list of the missing was incomplete. She said detectives were concerned about being overwhelmed with calls from relatives if the entire list were released."We can't release them all at once," McMann said. "So they are releasing the names in batches." She said the list would be updated.Authorities have not updated the total number of missing since Sunday, when 228 people were unaccounted for.Meanwhile, friends and relatives of the missing grew increasingly desperate. A message board at a shelter was filled with photos of the missing and pleas for any information."I hope you are okay," read one hand-written note on the board filled with sheets of notebook paper. Another had a picture of a missing man: "If seen, please have him call."Some of the missing are not on the list, said Sol Bechtold, who is searching for his 75-year-old mother, Joanne Caddy, whose house burned down along with the rest of her neighborhood in Magalia, just north of Paradise, the town of 27,000 that was consumed by flames last week.Bechtold said he spoke with the sheriff's office Wednesday morning, and they confirmed they have an active missing person's case on Caddy. But Caddy, a widow who lived alone and did not drive, was not on the list."The list they published is missing a lot of names," Bechtold said. Community members have compiled their own list.Greg Gibson was one of the people searching the message board Tuesday, hoping to find information about his neighbors. They've been reported missing, but he does not know if they tried to escape or hesitated a few minutes too long before fleeing Paradise, where about 7,700 homes were destroyed."It happened so fast. It would have been such an easy decision to stay, but it was the wrong choice," Gibson said from the Neighborhood Church in Chico, California, which was serving as a shelter for some of the more than 1,000 evacuees.Inside the church, evacuee Harold Taylor chatted with newfound friends. The 72-year-old Vietnam veteran, who walks with a cane, said he received a call Thursday morning to evacuate immediately. He saw the flames leaping up behind his house, left with the clothes on his back and barely made it out alive.Along the way, he tried to convince his neighbor to get in his car and evacuate with him, but the neighbor declined. He doesn't know what happened to his friend."We didn't have 10 minutes to get out of there," he said. "It was already in flames downtown, all the local restaurants and stuff," he said.The search for the dead was drawing on portable devices that can identify someone's genetic material in a couple of hours, rather than days or weeks.Before the Paradise tragedy, the deadliest single fire on record in California was a 1933 blaze in Griffith Park in Los Angeles that killed 29.The cause of the fires remained under investigation, but they broke out around the time and place that two utilities reported equipment trouble. Gov.-elect Gavin Newsom, who takes office in January, sidestepped questions about what action should be taken against utilities if their power lines are found to be responsible.People who lost homes in the Northern California blaze sued Pacific Gas & Electric Co. on Tuesday, accusing the utility of negligence and blaming it for the fire. An email to PG&E was not immediately returned.Linda Rawlings was on a daylong fishing trip with her husband and 85-year-old father when the fire broke out.Her next-door neighbors opened the back gate so her three dogs could escape before they fled the flames, and the dogs were picked up several days later waiting patiently in the charred remains of their home, she said.After days of uncertainty, Rawlings learned Tuesday that her "Smurf blue" home in Magalia burned to the ground.She sat looking shell-shocked on the curb outside a hotel in Corning."Before, you always have hope," she said. "You don't want to give up. But now we know."___Contributing to this report were Associated Press writers Sudhin Thanawala, Janie Har, Jocelyn Gecker and Olga R. Rodriguez in San Francisco. 5345

Police Chief Mike Koval in Madison, Wisconsin arrested WISC-TV Meteorologist Dave Caufield during a live newscast for "stealing spring," according to the station.Koval and Capt. Cory Nelson 'arrested' Caufield for charges of spreading false hope for warmer weather and not following through on promises."You are so infatuated with breaking records that we believe you are instigating this prolonged pain and misery," Koval said.Caufield said he's taking the fall for Mother Nature's crimes.Although we're all upset about the weather, the only one to blame here is Mother Nature herself. The Madison Police Department will not actually be pressing charges against Dave Caufield.  721

Parents deported from the US while their children were left behind is what experts think has happened to hundreds of families.A court-appointed steering committee began trying to reach the families of more than 1,000 migrant children two years ago.That's after a federal court ordered the reunification of many families that had been separated at the border under the Trump administration's "zero tolerance" policy in 2018.According to a court filing Tuesday, the committee has been unable to reach the parents of 545 children.It believes most of them were deported without their children, and those children are still in the US with a sponsor.The Justice Department and the American Civil Liberties Union are leading the effort to locate the parents.The ACLU points out some of the children were babies when they were taken away from their families. 858

PHILADELPHIA (AP) — Loyalists of President Donald Trump have filed at least 15 legal challenges in Pennsylvania alone in an effort to reclaim the state’s 20 electoral votes. There's action, too, on the legal front in Georgia, Arizona, Nevada and Michigan as the president insists without evidence that the election was stolen from him. Yet election officials nationwide from both parties say there's been no conspiracy. Experts doubt the suits can reverse the outcome in a single state, let alone the election. Trump aides and allies have privately admitted as much, suggesting the challenges are designed more to stoke his base.Below is the latest:___ARIZONATHE CLAIMS: Trump’s campaign has sued seeking the manual inspection of potentially thousands of in-person Election Day ballots in metropolitan Phoenix that they allege were mishandled by poll workers and resulted in some ballot selections to be disregarded. The campaign is asking the court to bar the certification of election results until such a manual inspection is completed.Secretary of State Katie Hobbs’ office has called Trump’s lawsuit a repackaged version of a now-dismissed challenge over the use of Sharpies to complete Election Day ballots in metro Phoenix.WHAT’S NEXT: A judge will hear arguments in the case on Thursday.___GEORGIATHE CLAIMS: Georgia’s two Republican senators have demanded the resignation of the Republican secretary of state over what they say are “too many failures in Georgia elections this year.” But their statement didn’t specify what failures they had seen beyond “mismanagement and lack of transparency.”While the AP has not called the race, Biden leads Trump by more than 14,000 votes out of nearly 5 million votes in the state. A Democrat has not won Georgia’s Electoral College votes since 1992.Secretary of State Brad Raffensperger rejected the demands of Sens. David Perdue and Kelly Loeffler — who face January runoffs that will decide control of the U.S. Senate — and denied there had been widespread problems. On Wednesday, he announced an audit of presidential election results that will trigger a full hand tally.WHAT’S NEXT: The secretary of state said the process is slated to begin by the end of the week. He expects it to take until Nov. 20, which is the certification deadline.___MICHIGANTHE CLAIMS: The Trump campaign’s latest lawsuit, announced Tuesday night, alleges “illegal and ineligible ballots were counted” without providing proof.The lawsuit includes assertions from poll watchers that their challenges were ignored or that they weren’t allowed close enough to the vote counting. Some say they saw apparent double-counting of some ballots. Others alleged they saw signs of political bias, including poll workers rolling their eyes when they opened ballots with votes for Trump. Several people noted in affidavits that they saw poll workers or Democratic observers wearing masks or clothing supporting Black Lives Matter, implying that they therefore opposed Trump.There is no evidence anyone miscounted votes out of political motivation.WHAT’S NEXT: No hearing has been scheduled in the latest case. Injunctions sought in two other lawsuits were turned down. Another case is pending.___NEVADATHE CLAIMS: Two Trump campaign officials stood before a crowd of chanting protesters Sunday and, without evidence, claimed that there were thousands of potentially fraudulent votes, including votes cast on behalf of dead people and by people who were no longer Nevada residents.The election security agency at the Department of Homeland Security says states have strong safeguards to detect illegal voting under the names of the deceased, including signature matching and death records. Rumors that people 120 years and older voted in the election “are actually innocuous clerical errors or the result of intended data practices,” such as someone typing “1/1/1900” into a database as a placeholder item.The Trump campaign settled one lawsuit that was before the Nevada Supreme Court, saying it had reached an agreement with Clark County, which includes Las Vegas, to add more observers to a ballot-processing facility.Officials in Clark County said they have forwarded two allegations of ballots being cast in the name of dead voters to the Nevada Secretary of State, which declined to comment on ongoing investigations.WHAT’S NEXT: A lawsuit challenging the use of an optical scanning machine to count ballots and verify signatures is still pending.___PENNSYLVANIATHE CLAIMS: Trump loyalists have filed at least 15 legal challenges in Pennsylvania alone, some before Election Day arrived. Two pending cases involve a state Supreme Court decision before the election that allowed mail-in ballots to count if they were sent by Election Day and arrived up to three days later.The state estimates there are about 10,000 mail-in ballots at stake. Biden currently leads by about 50,000 votes.On Monday, Trump’s campaign sued to stop the certification of the election results in Pennsylvania, alleging that Republican votes were “illegally diluted by invalid ballots.” The lawsuit itself contained no evidence of voter fraud other than a smattering of allegations such as an election worker in Chester County altering “over-voted” ballots by changing votes that had been marked for Trump to another candidate.WHAT’S NEXT: Court hearings are scheduled in at least one pending case, while filing deadlines are ahead in others. Trump has won one victory: A state court ruled his campaign observers had to be allowed closer to the actual vote counting.___WISCONSINTHE CLAIMS: State Republicans are providing no evidence that any of the problems affected the overall outcome of the election.Instead, the effort appears aimed at sowing doubt in the election results among Trump supporters ahead of a possible recount. And one Republican has raised the remote possibility of setting aside the results altogether.The issues they have raised include clerks filling in addresses on absentee ballot envelopes and a vote-counting error in one county that was quickly corrected. The state’s top elections official, Meagan Wolfe, has said repeatedly that there were no problems with the election reported to her office and no complaints filed alleging any irregularities.But Republican Assembly Speaker Robin Vos has ordered an investigation into the election results. Said Rep. Joe Sanfelippo, a Republican appointed to the committee overseeing the probe: “If an investigation shows these actions affected the outcome of the election, we need to either declare this past election null and void and hold a new election or require our Electoral College delegates to correct the injustice with their votes.”Under state law, the Republican-controlled Legislature has no role in picking electors, who are bound to cast their vote for the winner of Wisconsin’s popular vote as certified by the state elections commission. The commission is chaired by a Democrat, and Democratic Gov. Tony Evers has to sign off on who the elections commission certifies as the winner.WHAT’S NEXT: Trump is expected to request a recount as soon as possible, likely Nov. 18 under state rules.___Associated Press journalists Scott Bauer in Madison, Wisconsin; Kate Brumback in Atlanta; Ben Fox in Washington; Ken Ritter in Las Vegas; Jacques Billeaud in Phoenix and Mark Scolforo in Harrisburg, Pennsylvania contributed to this report. 7414