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SAN FRANCISCO, June 14 (Xinhua) -- Apple updated its online store on Tuesday to begin offering unlocked models of iPhone 4 in the United States for the first time."The unlocked iPhone 4 requires an active micro-SIM card that you obtain from a supported GSM wireless carrier," said Apple in the product description. The iPhone requires a smaller version of the standard SIM (Subscriber Identity Module) card.Started at 649 U.S. dollars for the 16 GB version, the unlocked model is a GSM phone, which means, in the United States, the phone runs on networks of T-Mobile or AT&T, although it can only send data over T-Mobile's old EDGE network, not its 3G network and the faster HSPA+ network.Verizon and Sprint, the other two major U.S. wireless carriers, both use CDMA networks that do not use SIM cards.The iPhone 4 has been sold unlocked in other countries. For frequent international travelers, an unlocked iPhone means they just need to pop in a micro-SIM card for whichever country they are going, avoiding provider's high international fees.According to Apple, iPhone sales grew 113 percent year over year in the second quarter of its fiscal 2011, reaching a record high of 18.65 million units.

LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.

JOHANNESBURG, June 1 (Xinhua) -- An estimated 2 million adolescents ages 10 to 19 are living with HIV, with 86 percent of them from sub-Saharan Africa, according to a global report on HIV prevention launched in Johannesburg on Wednesday.For the first time, the world gets to see the number of adolescents between the ages of 10 to 19 living with HIV in the report named Opportunity in Crisis: Preventing HIV from early adolescence to young adulthood.The report is a jointly publication by the United Nations Children's Fund (UNICEF), UNAIDS, the United Nations Educational, Scientific and Cultural Organization (UNESCO), the United Nations Population Fund (UNFPA), the International Labor Organization (ILO) , the World Health Organization (WHO) and World Bank.According to the report, people aged 15-24 accounted for 41 percent of new infections over the age of 15 in 2009. Worldwide, an estimated 5 million young people in that age group were living with HIV in 2009. Most of them live in sub-Saharan Africa. Globally, young women make up more than 60 percent of all young people living with HIV. In sub-Saharan Africa that rate jumped to 72 percent.Despite these challenges, the report acknowledges that some progress has been made in preventing new infections among young people."In many high-burden countries, HIV prevalence and incidence have declined among young people. While in 2001 there were 5.7 million young people living with HIV, the figure stands at 5 million (in 2009)," said the UNICEF eastern and southern Africa regional director, Elhadj As Sy, at the media briefing.He pointed that sexual transmission and injection drug use remain the major modes of transmission of HIV among young people. Early sexual debut, early pregnancy and early experiences with drug use all raise risks for HIV infection.The report reveals that unemployment and poverty are reported as the main reasons young people enter the sex trade. Worldwide, many young people driven by economic pressure, exploitation, social exclusion and lack of family support turn to commercial sex and injecting drug use.In 2001, the world made a commitment to reduce the prevalence of HIV among young people by 25 percent by 2010. The actual reduction achieved (from 5.7 million to 5 million) is 12 percent, and it represents less than half the target percentage."To avoid the current programming failures, we have to adopt a ' Continuum of Prevention Approach'." said Lina Mousa, deputy director of UNFPA Africa Regional Office."This continuum of prevention must be reflected in national HIV strategic plans, poverty reduction strategies and global fund proposals. This response must be developed with and for young people so that they own the response together with their communities," she added.To build this continuum of prevention for adolescents and young people, the reports outlined nine specific recommendations including providing young people with information and comprehensive sexuality education, strengthening child protection and social protection measures, engaging communities in shaping a positive social environment that promotes healthy behavior, establishing laws and policies that respect young people's rights.

BEIJING, Aug. 27 (Xinhua) -- Heavy rain battered several east China provinces Saturday, destroying homes and farmlands, while drought persisted in some of the country's arid central and southwestern regions.On Friday and Saturday, five counties in Anhui Province were hit by downpour, the provincial meteorological bureau said.It said 23 towns reported over 200 mm of rainfall in the 24 hours from 8 a.m. Friday to 8 a.m. Saturday. In some villages of Huaiyuan County, the precipitation topped 300 mm, about one third of the annual average volume.In Fengtai County alone, 2,048 people were stranded by rain-triggered flood. As of 9 p.m. Saturday, about 800 of them were still waiting for evacuation.Incomplete statistics provided by the provincial government said 280 houses toppled in the rain disaster and another 580 homes were damaged. About 54,800 hectares of cropland was drowned by rain and flood.The direct economic loss was estimated at 240 million yuan (37.6 million U.S. dollars), the provincial government said Saturday night.The provincial weather bureau forecast heavy rain will continue in most parts of Anhui in the coming three days.Heavy rain also wreaked havoc in seven cities and counties of the eastern Shandong Province, causing 230 million yuan of direct economic losses.Torrential rain that lasted more than 24 hours from Friday to Saturday afternoon forced evacuation of nearly 2,000 people in parts of Zaozhuang, Liaocheng and Linyi cities, the provincial civil affairs department said.It said nearly 500 homes toppled and more than 800 others were damaged.China Meteorological Administration has forecast heavy rain in the coming three days in Anhui, Shandong, Liaoning, Jiangxi provinces and parts of the Xinjiang Uygur Autonomous Region in the coming two to three days.Little rain has been predicted, however, for the drought-hit provinces in central and southwestern China, the administration said on its website.While the predicted rainfall for Guizhou, Sichuan, Chongqing, Yunnan, Hunan and Guangxi averages only 2 to 8 mm in four days from Aug. 28 to 31, it said the high temperature in these areas will still hover over 35 degrees Celsius.Affected by the approaching Typhoon Nanmadol, the coastal areas of Guangdong Province will experience high tides Sunday, but the scorching weather will stay next week, the provincial weather bureau said.The high temperature in most parts of the province has topped 35 degrees Celsius.

WASHINGTON, June 14 (Xinhua) -- Eating a low-carbohydrate, high- protein diet may reduce the risk of cancer and slow the growth of tumors already present, according to a study published Tuesday in Cancer Research, a journal of the American Association for Cancer Research.The study was conducted in mice, but the scientists involved agree that the strong biological findings are definitive enough that an effect in humans can be considered."This shows that something as simple as a change in diet can have an impact on cancer risk," said lead researcher Gerald Krystal, a scientist at the British Columbia Cancer Research Center.Krystal and his colleagues implanted various strains of mice with human tumor cells or with mouse tumor cells and assigned them to one of two diets. The first diet, a typical Western diet, contained about 55 percent carbohydrate, 23 percent protein and 22 percent fat. The second, which is somewhat like a South Beach diet but higher in protein, contained 15 percent carbohydrate, 58 percent protein and 26 percent fat. They found that the tumor cells grew consistently slower on the second diet.As well, mice genetically predisposed to breast cancer were put on these two diets and almost half of them on the Western diet developed breast cancer within their first year of life while none on the low-carbohydrate, high-protein diet did. Interestingly, only one on the Western diet reached a normal life span ( approximately 2 years), with 70 percent of them dying from cancer while only 30 percent of those on the low-carbohydrate diet developed cancer and more than half these mice reached or exceeded their normal life span.Krystal and colleagues also tested the effect of an mTOR inhibitor, which inhibits cell growth, and a COX-2 inhibitor, which reduces inflammation, on tumor development, and found these agents had an additive effect in the mice fed the low-carbohydrate, high-protein diet.When asked to speculate on the biological mechanism, Krystal said that tumor cells, unlike normal cells, need significantly more glucose to grow and thrive. Restricting carbohydrate intake can significantly limit blood glucose and insulin, a hormone that has been shown in many independent studies to promote tumor growth in both humans and mice.Furthermore, a low-carbohydrate, high-protein diet has the potential to both boost the ability of the immune system to kill cancer cells and prevent obesity, which leads to chronic inflammation and cancer.