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LOS ANGELES, July 28 (Xinhua) -- Mainly due to rampant obesity, Americans' life expectancy is one-and-a-half-year shorter than that of Western Europeans on the average, according to a new study published on Thursday.But 40 years ago, Americans could expect to live slightly longer than Europeans, said the study jointly conducted by researchers from University of Southern California (USC), the Harvard School of Public Health and the RAND Corp., a non-profit think tank.In addition to Western Europeans, Americans also die younger than the residents of most other developed nations, according to the study appearing in the July issue of Social Science & Medicine.The life-expectancy disparity, which begins around the age of 50, stems from higher levels of middle-age obesity and obesity-related chronic diseases, such as hypertension and diabetes, said the study.In the first half of the last century, average life expectancy increased by saving more babies, said author Dana Goldman, director of the Schaeffer Center for Health Policy and Economics at the USC."But now it is reduction in mortality among the elderly, rather than the young, that propels increases in life expectancy," he said. "The question is whether 'being American' is an independent mortality risk factor."If 50-year-old U.S. adults could be as healthy as Europeans, it could save Medicare and Medicaid 632 billion dollars by 2050, the study said.Though the transition to better health initially raises expenditures, the researchers estimate that by 2050 healthcare savings from health improvements among the middle age could total more than 1.1 trillion dollars."The international life expectancy gap appears much easier to explain than gaps within countries: there is no American-specific effect on longevity beyond differences in disease at age 50," said Darius Lakdawalla, an associate professor in the USC School of Policy, Planning and Development.
CANBERRA, Sept. 7 (Xinhua) -- A team of Australian and U.S. scientists on Wednesday said they discovered a genetic defect, which can lead to Leigh syndrome, a rare disorder which affects the central nervous syndrome.The scientists tested more than 1000 genes by encoding proteins active in two individuals who suffer from the illness. They used a new technique known as next-generation DNA sequencing to examine the genes.The gene they discovered encodes an enzyme which is found in the mitochondria which are subsets of cells. Without this enzyme the mitochondria do not translate proteins efficiently, and this then causes Leigh syndrome.According to David Thorburn, from the Murdoch Children's Research Institute in Melbourne, the discovery shows the enormous potential of the new technology."These findings demonstrate the ability of sequencing technologies to improve diagnosis," Professor Thorburn said in a statement released on Wednesday."Although it isn't clear in the case of Leigh syndrome whether the precise molecular diagnosis will necessarily lead to therapies, the current findings represent a meaningful service."He added that diagnosis of the disease along with its specific genetic cause can also be informative about the risk a couple has of having another affected child. The diagnostic information can help in decisions about whether and how to pursue alternative means of having children, for instance through the use of donor sperm or eggs.The research team consisted of scientists from Australia's Murdoch Institute as well as the Broad Institute in the U.S.In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of three. The problem is that the mitochondria responsible for powering their cells cannot keep up with the demand for energy in their developing brains.
WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.
TAIYUAN, May 29 (Xinhua) -- Parents of children with cerebral palsy are going to have a place to turn for help, as the first public foundation to provide aid has been set up in northern Shanxi Province.The Brain Rehabilitation Fund was established on Saturday by the China Population Welfare Foundation (CPWF), which is headquartered in Beijing. The CPWF will cooperate with the Shanxi Cerebral Palsy Hospital, which specializes in curing the brain disease with therapies such as acupuncture and massage.Lan Ye, the deputy secretary general of the CPWF, said the fund aims to relieve the burden of affected families by providing financial assistance and training so parents are able to do the therapy at home. In addition, the fund hopes to reduce the incidence of cerebral palsy by publicizing preventative measures to thwart the disease.More than 6 million suffer from cerebral palsy in China, and among them more than 2 million are children, said Guo Xinzhi, vice president of the Shanxi's Federation of the Disabled."A family needs to spend more than 500,000 yuan (77,000 U.S. dollars) to cure a child with the disease," Guo said. "As 70 percent of the children with cerebral palsy are from poor, mountainous areas, more than 25.7 percent of families cannot afford to pay the medical expenses."On Saturday, 25 parents from Xinjiang Uygur Autonomous Region, Fujian, Henan and Shanxi provinces came to the hospital for free training on helping their children to recover at home.
LOS ANGELES, June 23 (Xinhua) -- The sun and its inner planets may have formed differently than previously thought, NASA's Jet Propulsion Laboratory (JPL) said on Thursday.Data revealed differences between the sun and planets in oxygen and nitrogen, which are two of the most abundant elements in our solar system, said JPL in Pasadena, Los Angeles.Although the difference is slight, the implications could help determine how our solar system evolved, JPL said.NASA researchers drew the conclusion after analyzing samples returned by NASA's 2004 Genesis mission, according to JPL.The air on Earth contains three different kinds of oxygen atoms which are differentiated by the number of neutrons they contain. Nearly 100 percent of oxygen atoms in the solar system are composed of O-16, but there are also tiny amounts of more exotic oxygen isotopes called O-17 and O-18. Researchers studying the oxygen of Genesis samples found that the percentage of O-16 in the sun is slightly higher than on Earth or on other terrestrial planets. The other isotopes' percentages were slightly lower."We found that Earth, the moon, as well as Martian and other meteorites which are samples of asteroids, have a lower concentration of the O-16 than does the sun," said Kevin McKeegan, a Genesis co-investigator from University of California, Los Angeles (UCLA) and the lead author of one of two papers published this week in Science journal. "The implication is that we did not form out of the same solar nebula materials that created the sun -- just how and why remains to be discovered." Another paper detailed differences between the sun and planets in the element nitrogen. Like oxygen, nitrogen has one isotope, N- 14, that makes up nearly 100 percent of the atoms in the solar system, but there is also a tiny amount of N-15. Researchers studying the same samples saw that when compared to Earth's atmosphere, nitrogen in the sun and Jupiter has slightly more N-14, but 40 percent less N-15. Both the sun and Jupiter appear to have the same nitrogen composition. As is the case for oxygen, Earth and the rest of the inner solar system are very different in nitrogen."These findings show that all solar system objects including the terrestrial planets, meteorites and comets are anomalous compared to the initial composition of the nebula from which the solar system formed," said Bernard Marty, a Genesis co- investigator from Petrographic and Geochemical Research Center in Fracne and the lead author of the other new Science paper. " Understanding the cause of such a heterogeneity will impact our view on the formation of the solar system."Data were obtained from analysis of samples Genesis collected from the solar wind, or material ejected from the outer portion of the sun. This material can be thought of as a fossil of our nebula because the preponderance of scientific evidence suggests that the outer layer of our sun has not changed measurably for billions of years."The sun houses more than 99 percent of the material currently in our solar system, so it's a good idea to get to know it better, " said Genesis Principal Investigator Don Burnett of the California Institute of Technology, Pasadena, California. "While it was more challenging than expected, we have answered some important questions, and like all successful missions, generated plenty more."Genesis was launched in August 2000. The spacecraft traveled to Earth's L1 Lagrange Point about one million miles from Earth, where it remained for 886 days between 2001 and 2004, passively collecting solar-wind samples.JPL managed the Genesis mission for NASA's Science Mission Directorate, Washington. The Genesis mission was part of the Discovery Program managed at NASA's Marshall Space Flight Center in Huntsville, Alasca.